Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Aarti Jagannath"'
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2024)
Multiple studies have documented sex differences in sleep behaviour, however, the molecular determinants of such differences remain unknown. Furthermore, most studies addressing molecular mechanisms have been performed only in males, leaving the curr
Externí odkaz:
https://doaj.org/article/c5119e885553480ba73322abf7ea88c1
Autor:
Lewis Taylor, Steven Walsh, Anna Ashton, Norbert Varga, Sejal Kapoor, Charlotte George, Aarti Jagannath
Publikováno v:
Heliyon, Vol 9, Iss 6, Pp e17362- (2023)
Whilst the regulation of chromatin accessibility and its effect on gene expression have been well studied in eukaryotic species, the role of chromatin dynamics and 3D organisation in genome reduced bacteria remains poorly understood [1,2]. In this st
Externí odkaz:
https://doaj.org/article/0d8df407371b4758b8f75dee635fd68f
Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection
Autor:
Lewis Taylor, Felix Von Lendenfeld, Anna Ashton, Harshmeena Sanghani, Simona Di Pretoro, Laura Usselmann, Maria Veretennikova, Robert Dallmann, Jane A. McKeating, Sridhar Vasudevan, Aarti Jagannath
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105877- (2023)
Summary: Sleep and circadian rhythm disruption (SCRD), as encountered during shift work, increases the risk of respiratory viral infection including SARS-CoV-2. However, the mechanism(s) underpinning higher rates of respiratory viral infection follow
Externí odkaz:
https://doaj.org/article/a1abe26ff9904b94aa701cbd4db3ba41
Autor:
Aarti Jagannath, Simona Di Pretoro, Farid Ebrahimjee, Suzanne Ftouni, Lewis Taylor, Russell G. Foster, Sridhar Vasudevan
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Circadian entrainment in mice relies primarily on photic cues that trigger the transcription of the core clock genes Period1/2 in the suprachiasmatic nucleus (SCN), thus aligning the phase of the clock with the dawn/dusk cycle. It has been shown prev
Externí odkaz:
https://doaj.org/article/ba0c1419819a4e2d91bfd343c20b5f49
Autor:
Aarti Jagannath, Norbert Varga, Robert Dallmann, Gianpaolo Rando, Pauline Gosselin, Farid Ebrahimjee, Lewis Taylor, Dragos Mosneagu, Jakub Stefaniak, Steven Walsh, Teele Palumaa, Simona Di Pretoro, Harshmeena Sanghani, Zeinab Wakaf, Grant C. Churchill, Antony Galione, Stuart N. Peirson, Detlev Boison, Steven A. Brown, Russell G. Foster, Sridhar R. Vasudevan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Sleep pressure and circadian rhythms influence one another. However, the regulatory mechanisms are unclear. Here, the authors show that adenosine A1/A2A receptor antagonists, such as caffeine, shift circadian rhythms and enhance the effects of light,
Externí odkaz:
https://doaj.org/article/fe29a732cf334692a98923abc1d068d8
Autor:
Xiaodong Zhuang, Senko Tsukuda, Florian Wrensch, Peter A.C. Wing, Mirjam Schilling, James M. Harris, Helene Borrmann, Sophie B. Morgan, Jennifer L. Cane, Laurent Mailly, Nazia Thakur, Carina Conceicao, Harshmeena Sanghani, Laura Heydmann, Charlotte Bach, Anna Ashton, Steven Walsh, Tiong Kit Tan, Lisa Schimanski, Kuan-Ying A. Huang, Catherine Schuster, Koichi Watashi, Timothy S.C. Hinks, Aarti Jagannath, Sridhar R. Vausdevan, Dalan Bailey, Thomas F. Baumert, Jane A. McKeating
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103144- (2021)
Summary: The coronavirus disease 2019 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus, is a global health issue with unprecedented challenges for public health. SARS-CoV-2 primarily infects cells of the re
Externí odkaz:
https://doaj.org/article/9e863295d0ed4df8a498ce0d3e971ee4
Disrupted Sleep and Circadian Rhythms in Schizophrenia and Their Interaction With Dopamine Signaling
Autor:
Anna Ashton, Aarti Jagannath
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Sleep and circadian rhythm disruption (SCRD) is a common feature of schizophrenia, and is associated with symptom severity and patient quality of life. It is commonly manifested as disturbances to the sleep/wake cycle, with sleep abnormalities occurr
Externí odkaz:
https://doaj.org/article/2045cae66e90484fb905394e50bde030
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 729 (2022)
Circadian rhythms are essential for the survival of all organisms, enabling them to predict daily changes in the environment and time their behaviour appropriately. The molecular basis of such rhythms is the circadian clock, a self-sustaining molecul
Externí odkaz:
https://doaj.org/article/04132534e56b4cfc97fe5fc42ba9d05a
Autor:
Violetta Pilorz, Shu K E Tam, Steven Hughes, Carina A Pothecary, Aarti Jagannath, Mark W Hankins, David M Bannerman, Stafford L Lightman, Vladyslav V Vyazovskiy, Patrick M Nolan, Russell G Foster, Stuart N Peirson
Publikováno v:
PLoS Biology, Vol 14, Iss 6, p e1002482 (2016)
Light plays a critical role in the regulation of numerous aspects of physiology and behaviour, including the entrainment of circadian rhythms and the regulation of sleep. These responses involve melanopsin (OPN4)-expressing photosensitive retinal gan
Externí odkaz:
https://doaj.org/article/8e54a1b7d6d44bfe9da8ac8da5e6e8c2
Autor:
David Pritchett, Aarti Jagannath, Laurence A Brown, Shu K E Tam, Sibah Hasan, Silvia Gatti, Paul J Harrison, David M Bannerman, Russell G Foster, Stuart N Peirson
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125523 (2015)
Sleep and/or circadian rhythm disruption (SCRD) is seen in up to 80% of schizophrenia patients. The co-morbidity of schizophrenia and SCRD may in part stem from dysfunction in common brain mechanisms, which include the glutamate system, and in partic
Externí odkaz:
https://doaj.org/article/c4b58918dccf4eff9c8d7e496512573c