Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Aarti, Krishnan"'
Autor:
Felix Wong, Aarti Krishnan, Erica J Zheng, Hannes Stärk, Abigail L Manson, Ashlee M Earl, Tommi Jaakkola, James J Collins
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 9, Pp 1-20 (2022)
Abstract Efficient identification of drug mechanisms of action remains a challenge. Computational docking approaches have been widely used to predict drug binding targets; yet, such approaches depend on existing protein structures, and accurate struc
Externí odkaz:
https://doaj.org/article/ad22b6add92747ceac4e104098c84d2d
Autor:
Matteo Lunghi, Joachim Kloehn, Aarti Krishnan, Emmanuel Varesio, Oscar Vadas, Dominique Soldati-Favre
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Coenzyme A (CoA) is an essential metabolite found in all organisms and its synthesis involves five conserved enzymatic steps and uses pantothenate (Pan) as a precursor. Here, Lunghi et al. examine the Pan synthesis pathway in Toxoplasma gondii and fi
Externí odkaz:
https://doaj.org/article/760ba6dad3434446ad5b05a1f7b99b8a
Autor:
Chandra Ramakrishnan, Aarti Krishnan, Samuel Francisco, Marc W Schmid, Giancarlo Russo, Alexandre Leitão, Andrew Hemphill, Dominique Soldati-Favre, Adrian B Hehl
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010955 (2022)
Cyst-forming Apicomplexa (CFA) of the Sarcocystidae have a ubiquitous presence as pathogens of humans and farm animals transmitted through the food chain between hosts with few notable exceptions. The defining hallmark of this family of obligate intr
Externí odkaz:
https://doaj.org/article/32c60b09b50947dda74d5e00dc308b11
Autor:
Evgeniya Schastnaya, Zrinka Raguz Nakic, Christoph H. Gruber, Peter Francis Doubleday, Aarti Krishnan, Nathan I. Johns, Jimin Park, Harris H. Wang, Uwe Sauer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
While phosphorylation is an essential post-translational modification in eukaryotes only recently the phosphoproteome of prokaryotes has been provided. Here, Schastnaya et al. mutate 52 phosphosites on 23 E. coli enzymes and apply metabolomics to pro
Externí odkaz:
https://doaj.org/article/2160c240cd0443caaf59b15567610f60
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010438 (2022)
Regulated microneme secretion governs motility, host cell invasion and egress in the obligate intracellular apicomplexans. Intracellular calcium oscillations and phospholipid dynamics critically regulate microneme exocytosis. Despite its importance f
Externí odkaz:
https://doaj.org/article/9fd7ee31f3c940829c93b0d3a8564892
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010124 (2021)
The Apicomplexa phylum comprises thousands of distinct intracellular parasite species, including coccidians, haemosporidians, piroplasms, and cryptosporidia. These parasites are characterized by complex and divergent life cycles occupying a variety o
Externí odkaz:
https://doaj.org/article/c25c93579c3e4132ab0833a335ef8d0a
Revisiting the Role of Toxoplasma gondii ERK7 in the Maintenance and Stability of the Apical Complex
Autor:
Nicolas Dos Santos Pacheco, Nicolò Tosetti, Aarti Krishnan, Romuald Haase, Bohumil Maco, Catherine Suarez, Bingjian Ren, Dominique Soldati-Favre
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
The conoid is an enigmatic, dynamic organelle positioned at the apical tip of the coccidian subgroup of the Apicomplexa, close to the apical polar ring (APR) from which the subpellicular microtubules (SPMTs) emerge and through which the secretory org
Externí odkaz:
https://doaj.org/article/31c8c574a1d646bcab8d8893148e577b
Publikováno v:
WIDER Working Paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3c31b851afbae91100c0c8eb4d7a328
https://doi.org/10.35188/unu-wider/2023/371-0
https://doi.org/10.35188/unu-wider/2023/371-0
Publikováno v:
Metabolites, Vol 11, Iss 2, p 61 (2021)
Obligate intracellular pathogens have coevolved with their host, leading to clever strategies to access nutrients, to combat the host’s immune response, and to establish a safe niche for intracellular replication. The host, on the other hand, has a
Externí odkaz:
https://doaj.org/article/a269efd1a423418a9948da675e13b1a8
A key concern of the global value chain (GVC) and global production network (GPN) literature relates to whether and how actors, especially in the Global South, upgrade by generating and capturing more value. To date, such research has predominantly f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d668936193b9ff9350a0eb8300f838
https://hdl.handle.net/11577/3455869
https://hdl.handle.net/11577/3455869
