Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Aarti, Balasubramani"'
Autor:
Brian C. Avanzino, Kirthana Prabhakar, Pranjali Dalvi, Sharon Hartstein, Hannes Kehm, Aarti Balasubramani, Andrew A. Boudreau, Ben Buelow, Karen Chang, Laura M. Davison, Suhasini Iyer, Vidyut Kalwit, Kristin Lewis Wilson, Harbani K. Malik-Chaudhry, Will Pierson, Geovanni Pineda, Udaya S. Rangaswamy, Sowmya Saiganesh, Ute Schellenberger, Harshad S. Ugamraj, Rodolfovan D. Yabut, Roland Buelow, Jocelyn Chapman, Nathan D. Trinklein, Katherine E. Harris
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
The use of T-cell engagers (TCEs) to treat solid tumors is challenging, and several have been limited by narrow therapeutic windows due to substantial on-target, off-tumor toxicities due to the expression of low levels of target antigens on healthy t
Externí odkaz:
https://doaj.org/article/9e96f15bb0a54d7bb137adf3be604c3c
Autor:
Katherine E. Harris, Kyle J. Lorentsen, Harbani K. Malik-Chaudhry, Kaitlyn Loughlin, Harish Medlari Basappa, Sharon Hartstein, Ghenima Ahmil, Nicole S. Allen, Brian C. Avanzino, Aarti Balasubramani, Andrew A. Boudreau, Karen Chang, Maria-Cristina Cuturi, Laura M. Davison, Dennis M. Ho, Suhasini Iyer, Udaya S. Rangaswamy, Preethi Sankaran, Ute Schellenberger, Roland Buelow, Nathan D. Trinklein
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The use of recombinant interleukin-2 (IL-2) as a therapeutic protein has been limited by significant toxicities despite its demonstrated ability to induce durable tumor-regression in cancer patients. The adverse events and limited efficacy o
Externí odkaz:
https://doaj.org/article/6280e71ffa694c31a509b1afcf87bff2
Autor:
Lawrence Fong, Serena Kwek, Rong Deng, Yuping Li, Kevin Dang, Giulia Castello, Starlynn C Clarke, Aarti Balasubramani, Andrew Boudreau, Laura Davison, Katherine E Harris, Duy Pham, Preethi Sankaran, Harshad S Ugamraj, Alec Starzinski, Suhasini Iyer, Wim van Schooten, Ute Schellenberger, Wenchao Sun, Nathan D Trinklein, Roland Buelow, Ben Buelow, Pranjali Dalvi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background Therapeutic options currently available for metastatic castration-resistant prostate cancer (mCRPC) do not extend median overall survival >6 months. Therefore, the development of novel and effective therapies for mCRPC represents an urgent
Externí odkaz:
https://doaj.org/article/b008929f34b84d778350eb4e4a7bcce4
Autor:
Starlynn C. Clarke, Biao Ma, Nathan D. Trinklein, Ute Schellenberger, Michael J. Osborn, Laure-Hélène Ouisse, Andrew Boudreau, Laura M. Davison, Katherine E. Harris, Harshad S. Ugamraj, Aarti Balasubramani, Kevin H. Dang, Brett Jorgensen, Heather Anne N. Ogana, Duy T. Pham, Payal P. Pratap, Preethi Sankaran, Ignacio Anegon, Wim C. van Schooten, Marianne Brüggemann, Roland Buelow, Shelley Force Aldred
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Heavy chain-only antibodies (HCAbs) do not associate with light chains and their VH regions are functional as single domains, forming the smallest active antibody fragment. These VH regions are ideal building blocks for a variety of antibody-based bi
Externí odkaz:
https://doaj.org/article/6a706cdfcb4649ab82279f4b31c5c13b
Autor:
Brian C. Avanzino, Kirthana Prabhakar, Pranjali Dalvi, Sharon Hartstein, Hannes Kehm, Aarti Balasubramani, Andrew A. Boudreau, Ben Buelow, Karen Chang, Laura M. Davison, Suhasini Iyer, Vidyut Kalwit, Harbani Malik-Chaudhry, Will Pierson, Geovanni Pineda, Udaya S. Rangaswamy, Sowmya Saiganesh, Ute Schellenberger, Harshad S. Ugamraj, Roland Buelow, Jocelyn Chapman, Nathan D. Trinklein, Katherine E. Harris
Publikováno v:
Cancer Research. 82:6244-6244
The use of T cell engagers (TCEs) to treat solid tumors in humans is challenging, and several have been limited by narrow therapeutic windows due to substantial toxicity. Dose-limiting toxicities of TCEs include cytokine release syndrome (CRS) and on
Autor:
Suhasini Iyer, Kaitlyn Loughlin, Andrew Boudreau, Dennis M. Ho, Laura Davison, Preethi Sankaran, Udaya Rangaswamy, Sharon Hartstein, Nicole S. Allen, Brian Avanzino, Harbani Kaur Malik-Chaudhry, Aarti Balasubramani, Ute Schellenberger, Karen Chang, Roland Buelow, Maria-Cristina Cuturi, Nathan D. Trinklein, Harish Medlari Basappa, Ghenima Ahmil, Kyle J. Lorentsen, Katherine E. Harris
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
The use of recombinant interleukin-2 (IL-2) as a therapeutic protein has been limited by significant toxicities despite its demonstrated ability to induce durable tumor-regression in cancer patients. The adverse events and limited efficacy of IL-2 tr
Autor:
Laura Davison, Suhasini Iyer, Roland Buelow, Rong Deng, Alec Starzinski, Wenchao Sun, Preethi Sankaran, Serena S. Kwek, Starlynn Clarke, Yuping Li, Nathan D. Trinklein, Lawrence Fong, Aarti Balasubramani, Pranjali Dalvi, Ute Schellenberger, Ben Buelow, Wim Van Schooten, Giulia Castello, Duy Pham, Andrew Boudreau, Harshad Ugamraj, Katherine E. Harris, Kevin Dang
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
BackgroundTherapeutic options currently available for metastatic castration-resistant prostate cancer (mCRPC) do not extend median overall survival >6 months. Therefore, the development of novel and effective therapies for mCRPC represents an urgent
Autor:
Katherine E. Harris, Suhasini Iyer, Starlynn Clarke, Pranjali Dalvi, Duy Pham, Yuping Li, Alexander Cheung, Lawrence Fong, Preethi Sankaran, Chiara Rancan, Ben Buelow, Kevin Dang, Laura Davison, Aarti Balasubramani, Alec Starzinski
Publikováno v:
Journal of Clinical Oncology. 38:e17583-e17583
e17583 Background: Castration resistant prostate cancer (CRPC) is an incurable disease and represents a significant unmet need. Prostate specific membrane antigen (PSMA) is a protein highly expressed on the surface of prostate cancer cells; expressio
Autor:
Aarti Balasubramani, Ute Schellenberger, Harshad Ugamraj, Suhasini Iyer, Nathan D. Trinklein, Laura Davison, Brian Avanzino, Sharon Hartstein, Ben Buelow, Andrew Boudreau, Sowmya Saiganesh, Priya Ganesan, Duy Pham, Udaya Rangaswamy, Kirthana Prabhakar, Hannes Kehm, Harbani K. Malik-Chaudhry, Katherine E. Harris
Publikováno v:
Journal of Clinical Oncology. 38:e18050-e18050
e18050 Background: Ovarian Cancer (OvCa) is the leading cause of gynecologic cancer mortality in women. Since the introduction of platinum-based chemotherapy there has been little change in the prognosis of OvCa patients, with < 30% overall survival
Autor:
Laura Davison, Udaya Rangaswamy, Katherine M. Harris, Harshad Ugamraj, Ben Buelow, Duy Pham, Brett Jorgensen, Shelley Force Aldred, Aarti Balasubramani, Nathan D. Trinklein, Ute Schellenberger, Kevin Dang, Kirthana Prabhakar, Harbani Malik, Andrew Boudreau, Wim Van Schooten, Suhasini Iyer
Publikováno v:
Blood. 134:4070-4070
Introduction The restricted expression of CD19 in the B-cell lineage makes it an attractive target for the therapeutic treatment of B-cell malignancies. Many monoclonal antibodies and antibody drug conjugates targeting CD19 have been developed, inclu