Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Aarthi Ramakrishnan"'
Autor:
Amni Al-Kachak, Giuseppina Di Salvo, Sasha L. Fulton, Jennifer C Chan, Lorna A. Farrelly, Ashley E. Lepack, Ryan M. Bastle, Lingchun Kong, Flurin Cathomas, Emily L. Newman, Caroline Menard, Aarthi Ramakrishnan, Polina Safovich, Yang Lyu, Herbert E. Covington, Li Shen, Kelly Gleason, Carol A. Tamminga, Scott J. Russo, Ian Maze
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Mood disorders are an enigmatic class of debilitating illnesses that affect millions of individuals worldwide. While chronic stress clearly increases incidence levels of mood disorders, including major depressive disorder (MDD), stress-media
Externí odkaz:
https://doaj.org/article/b2c5b24c092e46f3a1215efcaf06b44a
Autor:
Valerie J. Marallano, Mary E. Ughetta, Rut Tejero, Sidhanta Nanda, Rohana Ramalingam, Lauren Stalbow, Anirudh Sattiraju, Yong Huang, Aarthi Ramakrishnan, Li Shen, Alexandre Wojcinski, Santosh Kesari, Hongyan Zou, Alexander M. Tsankov, Roland H. Friedel
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Glioblastoma (GBM) is the most common primary malignant cancer of the central nervous system. Insufficient oxygenation (hypoxia) has been linked to GBM invasion and aggression, leading to poor patient outcomes. Hypoxia induces gene expressio
Externí odkaz:
https://doaj.org/article/dd8338919ea04009b7ac965cd5a4e33e
Autor:
Shirelle X. Liu, Aarthi Ramakrishnan, Li Shen, Jonathan C. Gewirtz, Michael K. Georgieff, Phu V. Tran
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Iron deficiency (ID) during the fetal-neonatal period results in long-term neurodevelopmental impairments associated with pervasive hippocampal gene dysregulation. Prenatal choline supplementation partially normalizes these effect
Externí odkaz:
https://doaj.org/article/511ec710533a4bcf895fd68df659afb4
Autor:
Dalia Halawani, Yiqun Wang, Aarthi Ramakrishnan, Molly Estill, Xijing He, Li Shen, Roland H. Friedel, Hongyan Zou
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Axon regeneration of dorsal root ganglia (DRG) neurons after peripheral axotomy involves reconfiguration of gene regulatory circuits to establish regenerative gene programs. However, the underlying mechanisms remain unclear. Here, through an
Externí odkaz:
https://doaj.org/article/66436afe3fff457c990dac6982d2545e
Autor:
Sasha L. Fulton, Wendy Wenderski, Ashley E. Lepack, Andrew L. Eagle, Tomas Fanutza, Ryan M. Bastle, Aarthi Ramakrishnan, Emma C. Hays, Arianna Neal, Jaroslav Bendl, Lorna A. Farrelly, Amni Al-Kachak, Yang Lyu, Bulent Cetin, Jennifer C. Chan, Tina N. Tran, Rachael L. Neve, Randall J. Roper, Kristen J. Brennand, Panos Roussos, John C. Schimenti, Allyson K. Friedman, Li Shen, Robert D. Blitzer, Alfred J. Robison, Gerald R. Crabtree, Ian Maze
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The molecular mechanisms underlying deficits in Down syndrome remain unclear. Here, the authors show that copy number restoration of a chromatin remodeler in trisomic mice is sufficient to rescue epigenomic, physiological and cognitive deficits.
Externí odkaz:
https://doaj.org/article/4d9fc438d0e34047a77c7e2c58308fbb
Autor:
Lorna A. Farrelly, Shuangping Zheng, Nadine Schrode, Aaron Topol, Natarajan V. Bhanu, Ryan M. Bastle, Aarthi Ramakrishnan, Jennifer C Chan, Bulent Cetin, Erin Flaherty, Li Shen, Kelly Gleason, Carol A. Tamminga, Benjamin A. Garcia, Haitao Li, Kristen J. Brennand, Ian Maze
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Schizophrenia (SZ) is a severe psychiatric disorder; unfortunately, only ~1/3 of patients respond favorably to treatment. Here, the authors reveal hyperacetylation of histone H2A.Z in SZ neurons and postmortem SZ human brain tissues. They further sho
Externí odkaz:
https://doaj.org/article/82c68feb169f4133ac1edea10af43af7
Autor:
Flurin Cathomas, Laura Bevilacqua, Aarthi Ramakrishnan, Hope Kronman, Sara Costi, Molly Schneider, Kenny L. Chan, Long Li, Eric J. Nestler, Li Shen, Dennis S. Charney, Scott J. Russo, James W. Murrough
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Ketamine has rapid and sustained antidepressant effects in patients with treatment-resistant depression (TRD). However, the underlying mechanisms of action are not well understood. There is increasing evidence that TRD is associated with a p
Externí odkaz:
https://doaj.org/article/9578aab04ada4803bcc382d8a0f3d527
Autor:
Chrystian Junqueira Alves, Rafael Dariolli, Jonathan Haydak, Sangjo Kang, Theodore Hannah, Robert J. Wiener, Stefanie DeFronzo, Rut Tejero, Gabriele L. Gusella, Aarthi Ramakrishnan, Rodrigo Alves Dias, Alexandre Wojcinski, Santosh Kesari, Li Shen, Eric A. Sobie, José Paulo Rodrigues Furtado de Mendonça, Evren U. Azeloglu, Hongyan Zou, Roland H. Friedel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
Biomechanical mechanisms orchestrating stem cell dynamics in development remain unclear. Here the authors show that guidance receptor Plexin-B2 organizes actomyosin contractility, cytoskeletal tension and adhesion during multicellular development of
Externí odkaz:
https://doaj.org/article/ec4433536a404ae78838f90b72c22b29
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The vertebrate Six1 and Six2 arose by gene duplication from the Drosophila sine oculis and have since diverged in their developmental expression patterns. Both genes are expressed in nephron progenitors of human fetal kidneys, and mutations in SIX1 o
Externí odkaz:
https://doaj.org/article/6d96adcb07114176b44b7858d0659540
Publikováno v:
BMC Genomics, Vol 20, Iss S12, Pp 1-14 (2019)
Abstract Background RNA-binding proteins (RBPs) are crucial in modulating RNA metabolism in eukaryotes thereby controlling an extensive network of RBP-RNA interactions. Although previous studies on the conservation of RBP targets have been carried ou
Externí odkaz:
https://doaj.org/article/46248cb0eb1d4bd8a530419351c3ad08