Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Aart-Jan van der Lely"'
Autor:
Eva C. Coopmans, Paweena Chunharojrith, Sebastian J. C. M. M. Neggers, Marianne W. van der Ent, Sigrid M. A. Swagemakers, Iris H. Hollink, Barbara H. Barendregt, Peter J. van der Spek, Aart-Jan van der Lely, P. Martin van Hagen, Virgil A. S. H. Dalm
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: Primary antibody deficiencies (PADs) and anterior pituitary dysfunction are both rare conditions. However, recent studies have remarkably reported the occurrence of anterior pituitary dysfunction in PAD patients.Methods: In this cross-sec
Externí odkaz:
https://doaj.org/article/622b97300e854b658c823076d28e6ee6
Autor:
Anita Hokken-Koelega, Aart-Jan van der Lely, Berthold Hauffa, Gabriele Häusler, Gudmundur Johannsson, Mohamad Maghnie, Jesús Argente, Jean DeSchepper, Helena Gleeson, John W Gregory, Charlotte Höybye, Fahrettin Keleştimur, Anton Luger, Hermann L Müller, Sebastian Neggers, Vera Popovic-Brkic, Eleonora Porcu, Lars Sävendahl, Stephen Shalet, Bessie Spiliotis, Maithé Tauber
Publikováno v:
Endocrine Connections, Vol 5, Iss 6, Pp R44-R54 (2016)
Objective: Seamless transition of endocrine patients from the paediatric to adult setting is still suboptimal, especially in patients with complex disorders, i.e., small for gestational age, Turner or Prader–Willi syndromes; Childhood Cancer Surviv
Externí odkaz:
https://doaj.org/article/7a57380673164f058f26701f6ab3c4d0
Autor:
Darko M Stevanovic, Aldo Grefhorst, Axel P N Themmen, Vera Popovic, Joan Holstege, Elize Haasdijk, Vladimir Trajkovic, Aart-Jan van der Lely, Patric J D Delhanty
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98180 (2014)
Ghrelin, the endogenous growth hormone secretagogue, has an important role in metabolic homeostasis. It exists in two major molecular forms: acylated (AG) and unacylated (UAG). Many studies suggest different roles for these two forms of ghrelin in en
Externí odkaz:
https://doaj.org/article/f9a274f4f63845a2ae70b650233d90f0
Autor:
Karin Blijdorp, Marry M van den Heuvel-Eibrink, Rob Pieters, Annemieke M Boot, Patric J D Delhanty, Aart-Jan van der Lely, Sebastian J C M M Neggers
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43269 (2012)
OBJECTIVE: Obesity, represented by high body mass index (BMI), is a major complication after treatment for childhood cancer. However, it has been shown that high total fat percentage and low lean body mass are more reliable predictors of cardiovascul
Externí odkaz:
https://doaj.org/article/121ebcb4a7d14749969ae6900ee44ff7
Autor:
Patric J D Delhanty, Yuxiang Sun, Jenny A Visser, Anke van Kerkwijk, Martin Huisman, Wilfred F J van Ijcken, Sigrid Swagemakers, Roy G Smith, Axel P N Themmen, Aart-Jan van der Lely
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11749 (2010)
There is increasing evidence that unacylated ghrelin (UAG) improves insulin sensitivity and glucose homeostasis; however, the mechanism for this activity is not fully understood since a UAG receptor has not been discovered.To assess potential mechani
Externí odkaz:
https://doaj.org/article/5ce28b96fc8c4b23a3a76e22b5b88c60
Autor:
Kirsten Davidse, Anneloes van Staa, Wanda Geilvoet, Judith P van Eck, Karlijn Pellikaan, Janneke Baan, Anita C S Hokken-Koelega, Erica L T van den Akker, Theo Sas, Sabine E Hannema, Aart Jan van der Lely, Laura C G de Graaff
Publikováno v:
Endocrine Connections, Vol 11, Iss 5, Pp 1-9 (2022)
Introduction: Transition from paediatric to adult endocrinology can be challenging for adolescents, their families and healthcare professionals. Previous studies have shown that up to 25% of young adults with endocrine disorders are lost to follow-up
Externí odkaz:
https://doaj.org/article/cd9ce8248c13458b9860b13aea53d851
Autor:
Behiye Özcan, Patric J. D. Delhanty, Martin Huisman, Jenny A. Visser, Sebastian J. Neggers, Aart Jan van der Lely
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 13, Iss 1, Pp 1-7 (2021)
Abstract Background Several studies have demonstrated suppressed levels of acylated (AG) and unacylated ghrelin (UAG) in patients with type 2 diabetes. However, the role of these hormones in type 1 diabetes has not been extensively studied. This stud
Externí odkaz:
https://doaj.org/article/4a2f1cf6a22b4fc78f5d5f0ca9824136
Autor:
Greisa Vila, Anton Luger, Aart Jan van der Lely, Sebastian J. C. M. M. Neggers, Susan M. Webb, Beverly M. K. Biller, Srinivas Valluri, Judith Hey-Hadavi
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
ContextHypertension is a major cardiovascular risk factor related to increased mortality in acromegaly. Surgical cure of acromegaly is associated with improvement in blood pressure levels, however little is known about the effect of pegvisomant (PEGV
Externí odkaz:
https://doaj.org/article/67bdf8f844374ea1a8b1de1c2ec9e0d9
Publikováno v:
Slagboom, T N A, van Bunderen, C C, van der Lely, A J & Drent, M L 2023, ' Sex Differences in Long-Term Safety and Tolerability of GH Replacement Therapy in GH Deficient Adults ', The Journal of clinical endocrinology and metabolism, vol. 108, no. 7, pp. e415-e424 . https://doi.org/10.1210/clinem/dgad013
Journal of Clinical Endocrinology and Metabolism, 108, 7, pp. e415-e424
Journal of Clinical Endocrinology and Metabolism, 108, 7, pp. e415-e424
Context Previous studies report that outcomes of growth hormone (GH) replacement therapy (GHRT) might be less beneficial in growth hormone deficient (GHD) women compared with men. Objective This study investigated possible contributing factors regard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42880b843fa39c452b24a93e9407b3ad
https://research.vumc.nl/en/publications/3b75d5fa-5b2c-4806-89d9-3ae18f3c8261
https://research.vumc.nl/en/publications/3b75d5fa-5b2c-4806-89d9-3ae18f3c8261
Autor:
Selveta Sanne van Santen, Adrian F. Daly, Michael Buchfelder, Roland Coras, Yining Zhao, Albert Beckers, Aart Jan van der Lely, Leo J. Hofland, Rutger K. Balvers, P. van Koetsveld, Marry Marrigje van den Heuvel-Eibrink, Sebastian Johannes Cornelis Martinus Maria Neggers
Publikováno v:
AACE Clinical Case Reports, 8(3), 119-123. Elsevier Inc.
Background: Our objective was to describe the clinical course and treatment challenges in a very young patient with a pituitary adenoma due to a novel aryl hydrocarbon receptor–interacting protein (AIP) gene mutation, highlighting the limitations o