Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Aart G. Jochemsen"'
Autor:
Arwin Groenewoud, Jie Yin, Maria Chiara Gelmi, Samar Alsafadi, Fariba Nemati, Didier Decaudin, Sergio Roman-Roman, Helen Kalirai, Sarah E. Coupland, Aart G. Jochemsen, Martine J. Jager, Felix B. Engel, B. E. Snaar-Jagalska
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Uveal melanoma (UM) has a high risk to progress to metastatic disease with a median survival of 3.9 months after metastases detection, as metastatic UM responds poorly to conventional and targeted chemotherapy and is largely refractory to im
Externí odkaz:
https://doaj.org/article/35f875d9b6ee4910a5099e5b1b9ef6e8
Autor:
Malcy Tarin, Fariba Némati, Didier Decaudin, Christine Canbezdi, Benjamin Marande, Lisseth Silva, Héloïse Derrien, Aart G. Jochemsen, Sophie Gardrat, Sophie Piperno-Neumann, Manuel Rodrigues, Pascale Mariani, Nathalie Cassoux, Marc-Henri Stern, Sergio Roman-Roman, Samar Alsafadi
Publikováno v:
Cancers, Vol 15, Iss 8, p 2280 (2023)
Uveal Melanoma (UM) is a rare and malignant intraocular tumor with dismal prognosis. Even if radiation or surgery permit an efficient control of the primary tumor, up to 50% of patients subsequently develop metastases, mainly in the liver. The treatm
Externí odkaz:
https://doaj.org/article/143a61be6ac0494c822025071d9882ec
Autor:
Jie Yin, Gangyin Zhao, Helen Kalirai, Sarah E. Coupland, Aart G. Jochemsen, Gabriel Forn-Cuní, Annemijn P. A. Wierenga, Martine J. Jager, B. Ewa Snaar-Jagalska, Arwin Groenewoud
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 598 (2023)
Uveal melanoma (UM) is a rare malignant cancer of the eye, with up to 50% of patients dying from metastasis, for which no effective treatment is available. Due to the rarity of the disease, there is a great need to harness the limited material availa
Externí odkaz:
https://doaj.org/article/926cbf25627a4e6385fb3c70e89d75a4
Autor:
Renier C. Heijkants, Amina F. A. S. Teunisse, Danielle de Jong, Kseniya Glinkina, Hailiang Mei, Szymon M. Kielbasa, Karoly Szuhai, Aart G. Jochemsen
Publikováno v:
Cancers, Vol 14, Iss 18, p 4482 (2022)
The tumor suppressor protein p53 has an important role in cell-fate determination. In cancer cells, the activity of p53 is frequently repressed by high levels of MDMX and/or MDM2. MDM2 is a ubiquitin ligase whose activity results in ubiquitin- and pr
Externí odkaz:
https://doaj.org/article/dd3402b2c00149fcb12a271bc8c86d0e
Autor:
Javier Octavio Mejía-Hernández, Dinesh Raghu, Franco Caramia, Nicholas Clemons, Kenji Fujihara, Thomas Riseborough, Amina Teunisse, Aart G. Jochemsen, Lars Abrahmsén, Giovanni Blandino, Andrea Russo, Cristina Gamell, Stephen B. Fox, Catherine Mitchell, Elena A. Takano, David Byrne, Panimaya Jeffreena Miranda, Reem Saleh, Heather Thorne, Shahneen Sandhu, Scott G. Williams, Simon P. Keam, Ygal Haupt, Sue Haupt
Publikováno v:
Cancers, Vol 14, Iss 16, p 3947 (2022)
Metastatic prostate cancer is a lethal disease in patients incapable of responding to therapeutic interventions. Invasive prostate cancer spread is caused by failure of the normal anti-cancer defense systems that are controlled by the tumour suppress
Externí odkaz:
https://doaj.org/article/ff015e55998b4b289710d38ac8d67f09
Autor:
Kseniya Glinkina, Arwin Groenewoud, Amina F. A. S. Teunisse, B. Ewa Snaar-Jagalska, Aart G. Jochemsen
Publikováno v:
Cancers, Vol 14, Iss 13, p 3186 (2022)
Currently, no systemic treatment is approved as the standard of care for metastatic uveal melanoma (UM). mTOR has been evaluated as a drug target in UM. However, one of the main limitations is dose reduction due to adverse effects. The combination of
Externí odkaz:
https://doaj.org/article/3ac460b099014a78bbd59e0b568e1517
Autor:
Zahra Souri, Aart G. Jochemsen, Annemijn P. A. Wierenga, Wilma G. M. Kroes, Rob M. Verdijk, Pieter A. van der Velden, Gregorius P. M. Luyten, Martine J. Jager
Publikováno v:
Cancers, Vol 13, Iss 16, p 4146 (2021)
In Uveal Melanoma (UM), an inflammatory phenotype is strongly associated with the development of metastases and with chromosome 3/BAP1 expression loss. As an increased expression of several Histone Deacetylases (HDACs) was associated with loss of chr
Externí odkaz:
https://doaj.org/article/936d464868094b39a2f85852b256f536
Autor:
Laurens G. L. Sand, Tessa Buckle, Fijs W. B. van Leeuwen, Willem E. Corver, Alwine B. Kruisselbrink, Aart G. Jochemsen, Pancras C. W. Hogendoorn, Károly Szuhai
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-9 (2017)
Abstract Background Ewing sarcoma is an aggressive, highly metastatic primary bone and soft tissue tumor most frequently occurring in the bone of young adolescents. Patients, especially those diagnosed with a metastatic disease, have a poor overall s
Externí odkaz:
https://doaj.org/article/146633a273e64b18832ca1956fb90d90
Autor:
Zahra Souri, Aart G. Jochemsen, Mieke Versluis, Annemijn P.A. Wierenga, Fariba Nemati, Pieter A. van der Velden, Wilma G.M. Kroes, Robert M. Verdijk, Gregorius P.M. Luyten, Martine J. Jager
Publikováno v:
Cancers, Vol 12, Iss 12, p 3690 (2020)
The treatment of uveal melanoma (UM) metastases or adjuvant treatment may imply immunological approaches or chemotherapy. It is to date unknown how epigenetic modifiers affect the expression of immunologically relevant targets, such as the HLA Class
Externí odkaz:
https://doaj.org/article/af2db08c2a4d47919a160a98d746cb4e
Autor:
Zahra Souri, Annemijn P. A. Wierenga, Christiaan van Weeghel, Pieter A. van der Velden, Wilma G. M. Kroes, Gregorius P. M. Luyten, Sjoerd H. van der Burg, Aart G. Jochemsen, Martine J. Jager
Publikováno v:
Cancers, Vol 11, Iss 8, p 1102 (2019)
One of the characteristics of prognostically infaust uveal melanoma (UM) is an inflammatory phenotype, which is characterized by high numbers of infiltrating T cells and macrophages, and a high HLA Class I expression. We wondered how this inflammatio
Externí odkaz:
https://doaj.org/article/63c879cb9bc243caa399147ec3307ae4