Výsledky vyhledávání - "Aart G Jochemsen"

Akademický článek

Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy

Autor: Sjoerd H van der Burg, Suzanne van Duikeren, Ramon Arens, Thorbald van Hall, Ziena Abdulrahman, Elham Beyranvand Nejad, Jan Willem Kleinovink, Noel F C C de Miranda, Camilla Labrie, Marit J van Elsas, Eva Rademaker, Tetje C van der Sluis, Amina F A.S Teunisse, Aart G Jochemsen, Jan Oosting

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Background Immunotherapy of cancer is successful but tumor regression often is incomplete and followed by escape. Understanding the mechanisms underlying this acquired resistance will aid the development of more effective treatments.Methods We exploi

Externí odkaz: https://doaj.org/article/520202f95b084831848aa302833ae70b

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Akademický článek

Activation of cAMP Signaling Interferes with Stress-Induced p53 Accumulation in ALL-Derived Cells by Promoting the Interaction between p53 and HDM2

Autor: Elin Hallan Naderi, Aart G Jochemsen, Heidi Kiil Blomhoff, Soheil Naderi

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 7, Pp 653-663 (2011)

The tumor suppressor p53 provides an important barrier to the initiation and maintenance of cancers. As a consequence, p53 function must be inactivated for a tumor to develop. This is achieved by mutation in approximately 50% of cases and probably by

Externí odkaz: https://doaj.org/article/487a3610401747b1993e4b44bbe76fef

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Akademický článek

Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target

Autor: Arwin Groenewoud, Jie Yin, Maria Chiara Gelmi, Samar Alsafadi, Fariba Nemati, Didier Decaudin, Sergio Roman-Roman, Helen Kalirai, Sarah E. Coupland, Aart G. Jochemsen, Martine J. Jager, Felix B. Engel, B. E. Snaar-Jagalska

Publikováno v: Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023)

Abstract Uveal melanoma (UM) has a high risk to progress to metastatic disease with a median survival of 3.9 months after metastases detection, as metastatic UM responds poorly to conventional and targeted chemotherapy and is largely refractory to im

Externí odkaz: https://doaj.org/article/35f875d9b6ee4910a5099e5b1b9ef6e8

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Akademický článek

Zebrafish Patient-Derived Xenograft Model as a Preclinical Platform for Uveal Melanoma Drug Discovery

Autor: Jie Yin, Gangyin Zhao, Helen Kalirai, Sarah E. Coupland, Aart G. Jochemsen, Gabriel Forn-Cuní, Annemijn P. A. Wierenga, Martine J. Jager, B. Ewa Snaar-Jagalska, Arwin Groenewoud

Publikováno v: Pharmaceuticals, Vol 16, Iss 4, p 598 (2023)

Uveal melanoma (UM) is a rare malignant cancer of the eye, with up to 50% of patients dying from metastasis, for which no effective treatment is available. Due to the rarity of the disease, there is a great need to harness the limited material availa

Externí odkaz: https://doaj.org/article/926cbf25627a4e6385fb3c70e89d75a4

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