Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Aarron Willingham"'
Autor:
Svetlana Sadekova, Amy M. Beebe, Aarron Willingham, Terrill K. McClanahan, Danuta Herzyk, Wendy J. Bailey, Venkataraman Sriram, Elaine M. Pinheiro, Denise Manfra, Peter Georgiev, Ruban Mangadu, Tatyana Churakova, Jeff Grein, Antoaneta S. Necheva, Bhagyashree Bhagwat, Romina Riener, Grigori Ermakov, Saraswathi Naravula, Jerelyn Wong, Ying Yu, Douglas C. Wilson, Selvakumar Sukumar
Supplementary tables listing the affinities and bioactivities of MK-4166 and DTA-1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249f3473bfc76fc6a9343fe15e701207
https://doi.org/10.1158/0008-5472.22414407.v1
https://doi.org/10.1158/0008-5472.22414407.v1
Autor:
Svetlana Sadekova, Amy M. Beebe, Aarron Willingham, Terrill K. McClanahan, Danuta Herzyk, Wendy J. Bailey, Venkataraman Sriram, Elaine M. Pinheiro, Denise Manfra, Peter Georgiev, Ruban Mangadu, Tatyana Churakova, Jeff Grein, Antoaneta S. Necheva, Bhagyashree Bhagwat, Romina Riener, Grigori Ermakov, Saraswathi Naravula, Jerelyn Wong, Ying Yu, Douglas C. Wilson, Selvakumar Sukumar
This file contains supplementary methods that describe the antibodies used, the generation and characterization of MK-4166, various cell-based assays, and the evaluation of toxicity in cynomolgus monkeys.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69827d21a8c9e0175677d7a8489838f7
https://doi.org/10.1158/0008-5472.22414410.v1
https://doi.org/10.1158/0008-5472.22414410.v1
Autor:
Svetlana Sadekova, Amy M. Beebe, Aarron Willingham, Terrill K. McClanahan, Danuta Herzyk, Wendy J. Bailey, Venkataraman Sriram, Elaine M. Pinheiro, Denise Manfra, Peter Georgiev, Ruban Mangadu, Tatyana Churakova, Jeff Grein, Antoaneta S. Necheva, Bhagyashree Bhagwat, Romina Riener, Grigori Ermakov, Saraswathi Naravula, Jerelyn Wong, Ying Yu, Douglas C. Wilson, Selvakumar Sukumar
GITR is a T-cell costimulatory receptor that enhances cellular and humoral immunity. The agonist anti-mouse GITR antibody DTA-1 has demonstrated efficacy in murine models of cancer primarily by attenuation of Treg-mediated immune suppression, but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bfee5aa1afeba34ec05f3cba4f5fee8
https://doi.org/10.1158/0008-5472.c.6508965.v1
https://doi.org/10.1158/0008-5472.c.6508965.v1
Autor:
Svetlana Sadekova, Amy M. Beebe, Aarron Willingham, Terrill K. McClanahan, Danuta Herzyk, Wendy J. Bailey, Venkataraman Sriram, Elaine M. Pinheiro, Denise Manfra, Peter Georgiev, Ruban Mangadu, Tatyana Churakova, Jeff Grein, Antoaneta S. Necheva, Bhagyashree Bhagwat, Romina Riener, Grigori Ermakov, Saraswathi Naravula, Jerelyn Wong, Ying Yu, Douglas C. Wilson, Selvakumar Sukumar
Supplementary Figure S1 shows the gating scheme and markers used to phenotype various T cell subsets in human blood. Supplementary Figure S2 shows the expression of GITR on human and cynomolgus monkey NK cells and T cells. Supplementary Figure S3 sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b1719210763f1f05971391ff03d06a
https://doi.org/10.1158/0008-5472.22414413.v1
https://doi.org/10.1158/0008-5472.22414413.v1
Publikováno v:
International Immunopharmacology. 119:109566
Autor:
Beth, Hutchins, Gary C, Starling, Mark A, McCoy, Danuta, Herzyk, Frederique M, Poulet, John, Dulos, Liming, Liu, Soonmo Peter, Kang, Laurence, Fayadat-Dilman, Mark, Hsieh, Christine L, Andrews, Gulesi, Ayanoglu, Constance, Cullen, Rene de Waal, Malefyt, Robert A, Kastelein, Sabine Le, Saux, Julie, Lee, Sophie, Li, Dan, Malashock, Svetlana, Sadekova, George, Soder, Hans, van Eenennaam, Aarron, Willingham, Ying, Yu, Michel, Streuli, Gregory J, Carven, Andrea, van Elsas
Publikováno v:
Molecular cancer therapeutics. 19(6)
The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint, which may be engaged by cells in the tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®, MK-3475) is a potent and highly sel