Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Aaron Z Fernandis"'
Autor:
Anita Sugam Kale, Sonia Baig, Markus R. Wenk, S. Vasoo, Lin Lin Su, Arijit Biswas, Guanghou Shui, J.Y. Lim, Aaron Z. Fernandis, Mahesh Choolani
Publikováno v:
Placenta. 34:436-442
Syncytiotrophoblast microvesicles (STBM) are shed from placenta into the maternal circulation. STBM circulate in increased amounts in adverse pregnancies, e.g., preeclampsia and recurrent miscarriages (RM). Recently dysregulation of lipid metabolites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ffbdf681ffe880170bbc139c1c8ea8e
https://doi.org/10.1016/j.placenta.2013.02.004
https://doi.org/10.1016/j.placenta.2013.02.004
Autor:
Eugene Hone, Wei Ling F. Lim, Guanghou Shui, Kevin Taddei, Aaron Z. Fernandis, Tamar Berger, Jorge Ghiso, Sam Gandy, Ralph N. Martins, Joseph D. Buxbaum, Matthew J. Sharman, Markus R. Wenk, Ian Martins
Publikováno v:
Journal of Alzheimer's Disease. 20:105-111
It is known that apolipoprotein E (ApoE) is essential for normal lipid metabolism. ApoE is the major apolipoprotein in the central nervous system and plays a key role in neurobiology by mediating the transport of cholesterol, phospholipids, and sulfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec0de777ed710fe8bda56218b3607459
https://doi.org/10.3233/jad-2010-1348
https://doi.org/10.3233/jad-2010-1348
Autor:
Ka Yin Leung, Chacko Jobichen, Yu-Keung Mok, Adrián Velázquez-Campoy, J. Sivaraman, Aaron Z. Fernandis, Markus R. Wenk
Publikováno v:
Biochemical Journal. 420:191-201
Lipocalins are a broad family of proteins identified initially in eukaryotes and more recently in Gram-negative bacteria. The functions of lipocalin or lipid-binding proteins are often elusive and very diverse. Recently, we have determined the struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840e61702d371ffdcfb45788840172b1
https://doi.org/10.1042/bj20081588
https://doi.org/10.1042/bj20081588
Publikováno v:
Journal of Biological Chemistry. 279:9115-9124
Slit, which mediates its function by binding to the Roundabout (Robo) receptor, has been shown to regulate neuronal and CXCR4-mediated leukocyte migration. Slit-2 was shown to be frequently inactivated in lung and breast cancers because of hypermethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5e9b6f718b08d0f56372cb2b5d39ed
https://doi.org/10.1074/jbc.m308083200
https://doi.org/10.1074/jbc.m308083200
Publikováno v:
Oncogene. 23:157-167
The chemokine-CXCL12 and its receptor, CXCR4, have recently been shown to play an important role in regulating the directional migration of breast cancer cells to sites of metastasis. In the present study, we showed that CXCL12 enhanced the chemotaxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8823416ebb82967774c734720ea3ba
https://doi.org/10.1038/sj.onc.1206910
https://doi.org/10.1038/sj.onc.1206910
Publikováno v:
Journal of Biological Chemistry. 278:9536-9543
The chemokine receptor CXCR4 and its cognate ligand, stromal cell-derived factor-1alpha (CXCL12), regulate lymphocyte trafficking and play an important role in host immune surveillance. However, the molecular mechanisms involved in CXCL12-induced and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0249484c6ee2b30cd9f47b15e06c9604
https://doi.org/10.1074/jbc.m211803200
https://doi.org/10.1074/jbc.m211803200
Publikováno v:
The Journal of Immunology. 168:5860-5866
Endothelial injury is a major manifestation of septic shock induced by LPS. Recently, LPS was shown to induce apoptosis in different types of endothelial cells. In this study, we observed that pretreatment with vascular endothelial growth factor (VEG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a875540cd2f135e0c3706a470a7d1df1
https://doi.org/10.4049/jimmunol.168.11.5860
https://doi.org/10.4049/jimmunol.168.11.5860
Publikováno v:
Journal of Biological Chemistry. 277:18111-18117
Chemokines and their receptors play a critical role in host immune surveillance and are important mediators of human immunodeficiency virus (HIV) pathogenesis and inflammatory response. The chemokine receptors CCR5 and CXCR4, which act as co-receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c839996b314fd37bfa58dd3b9b5ecfcc
https://doi.org/10.1074/jbc.m200750200
https://doi.org/10.1074/jbc.m200750200
Publikováno v:
Molecular Immunology. 37:273-280
Recent evidence suggests that concanavalin A modulates tyrosyl phosphorylation and activation of a type II PtdIns 4-kinase in rat splenic lymphocytes. However, the regulatory protein tyrosine kinase(s) remain to be elusive. The present manuscript pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1325b79883eaca8b19c712501d86d3
https://doi.org/10.1016/s0161-5890(00)00053-5
https://doi.org/10.1016/s0161-5890(00)00053-5
Autor:
Aaron Z. Fernandis, Markus R. Wenk
Publikováno v:
2010 International Conference on Systems in Medicine and Biology.
Lipids play an important role in signaling mechanisms, regulation of protein function and control of a wide variety of cellular responses. As these lipids are important regulators their levels are tightly controlled and fine tuned both spatially as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdb09610a8d19d3a8f992d2d3e1a126d
https://doi.org/10.1109/icsmb.2010.5735332
https://doi.org/10.1109/icsmb.2010.5735332