Výsledky vyhledávání - "Aaron Williams"

Akademický článek

Preventing erosion of X-chromosome inactivation in human embryonic stem cells

Autor: Marissa Cloutier, Surinder Kumar, Emily Buttigieg, Laura Keller, Brandon Lee, Aaron Williams, Sandra Mojica-Perez, Indri Erliandri, Andre Monteiro Da Rocha, Kenneth Cadigan, Gary D. Smith, Sundeep Kalantry

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Cloutier et al. discover that human embryonic stem cells (hESCs) cultured with media containing inhibitors of GSK3 proteins undergo erosion of X-chromosome inactivation, which equalizes X-linked gene expression between females and males. The findings

Externí odkaz: https://doaj.org/article/1c9cb51453184bd78e06bdb940e324aa

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Akademický článek

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats

Publikováno v: eLife, Vol 11 (2022)

NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target NaV1.6 channels. Such a molecule provides a precision-medicine approach to target SCN8A-related epilepsy syndromes (SCN8A-RES), where gain-of-function (G

Externí odkaz: https://doaj.org/article/ff1c4ccf767e411f85c1b12a0db8fe55

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Akademický článek

Investigating the Health Effects of 3 Coexisting Tobacco-Related Products Using System Dynamics Population Modeling: An Italian Population Case Study

Autor: Oscar M. Camacho, Andrew Hill, Stacy Fiebelkorn, Aaron Williams, James Murphy

Publikováno v: Frontiers in Public Health, Vol 9 (2021)

With the proliferation of tobacco products, there might be a need for more complex models than current two-product models. We have developed a three-product model able to represent interactions between three products in the marketplace. We also inves

Externí odkaz: https://doaj.org/article/a07846a0076c4031af54bb25dd7c5db4

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Akademický článek

Hamming distance from irreducible polynomials over $\mathbb {F}_2$

Autor: Gilbert Lee, Frank Ruskey, Aaron Williams

Publikováno v: Discrete Mathematics & Theoretical Computer Science, Vol DMTCS Proceedings vol. AH,..., Iss Proceedings (2007)

We study the Hamming distance from polynomials to classes of polynomials that share certain properties of irreducible polynomials. The results give insight into whether or not irreducible polynomials can be effectively modeled by these more general c

Externí odkaz: https://doaj.org/article/9e511480bb7c4ea185b1da4bbf4fa8c0

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