Randomised comparative effectiveness trial of Pulmonary Embolism Prevention after hiP and kneE Replacement (PEPPER): the PEPPER trial protocol

Autor: Laurence S Magder, PJ Devereaux, Diane Smith, Laurence Magder, David J Warwick, Samuel Z Goldhaber, Jay S Magaziner, James A Browne, John Eikelboom, Rebecca Baron, Patrick Heagerty, Stephen L Kates, Vincent D Pellegrini, Jr, John William Eikelboom, C McCollister Evarts, Patricia D Franklin, Kevin L Garvin, Richard Iorio, Carol Ann Lambourne, Jay Magaziner, Eric M Cohen, Charles M Davis, Navin D Fernando, Kevin B Fricka, Richard J Friedman, Kevin L. Garvin, Michael S Kain, Brent A Lanting, Brock A Lindsey, William J Maloney, Robert M Molloy, Michael A Mont, Wayne E Moschetti, James Nace, Charles L Nelson, Kevin I Perry, James D Slover, Mark J Spangehl, Lawrence M Specht, Scott M Sporer, Robert S Sterling, Zeke J Walton, William L Healy, Charles W Francis, Vincent D Pellegrini, Monica Baczko, Carol A Lambourne, Brook I Martin, Ronald Blankstein, Carolyn Come, Jean Connors, Raymond Kwong, Greg Piazza, Rachel Rosovsky, Aaron Waxman, Roger Bulger, Ruth Bulger, Mary Beth Crummer, Debra Hamilton, Connie Persels, Robert Schlegel, Sally Seeley, Mitchell Thompson, Teresa Bordeaux, Kathryn Z Mikkelsen, Lisa K Moores

Publikováno v: BMJ Open, Vol 12, Iss 3 (2022)

Introduction More than 1 million elective total hip and knee replacements are performed annually in the USA with 2% risk of clinical pulmonary embolism (PE), 0.1%–0.5% fatal PE, and over 1000 deaths. Antithrombotic prophylaxis is standard of care b

Externí odkaz: https://doaj.org/article/c21d8bdb9eae4552a920adbd09818605

Emergent Pulmonary Embolism Management in Hospital Practice

Autor: Colm McCabe, Aaron Waxman

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3471a2718a4fc55ccd4a3355cbd7f5b8
https://doi.org/10.1142/q0376

Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension:A Double-Blind Placebo-controlled Clinical Trial

Autor: R. James White, Carlos Jerjes-Sanchez, Gisela Martina Bohns Meyer, Tomas Pulido, Pablo Sepulveda, Kuo Yang Wang, Ekkehard Grünig, Shirish Hiremath, Zaixin Yu, Zhang Gangcheng, Wei Luen James Yip, Shuyang Zhang, Akram Khan, C. Q. Deng, Rob Grover, Victor F. Tapson, Graciela Noemi Svetliza, Adrian Jose Lescano, Guillermo Roberto Bortman, Fabian Antonio Diez, Christian Edgardo Botta, John Fitzgerald, Eelke Feenstra, Fiona Dawn Kermeen, Anne Margaret Keogh, Trevor John Williams, Peter Paul Yousseff, Benjamin Joh-Han Ng, David McNaughton Smallwood, Nathan Brent Dwyer, Martin Russell Brown, Irene M Lang, Regina Steringer-Mascherbauer, Jaquelina Sonoe Ota Arakaki, Frederico Thadeu Assis Figueiredo Campos, Ricardo de Amorim Correa, Rogerio de Souza, Gisela M. Bohns Meyer, Maria Auxiliadora Carmo Moreira, Hugo Hyung Bok Yoo, Monica Silveira Lapa, John Swiston, Naushad Hirani, Sanjay Mehta, Evangelos Michelakis, Pablo Andres Sepulveda, Monica Maria Zagolin Blancaire, Jimming Liu, Zhang Shuyang, Lei Pan, Bao Chunde, Yi Qun, Cheng Xiaoshu, Yu Zaixin, Xinli Li, Yao Hua, Xianyang Zhu, Yundai Chen, Cheng Zhaozhong, Yuanhua Yang, Zhou Daxin, Shen Jieyan, Jens Erik Nielsen-Kudsk, Jorn Carlsen, Arnaud Bourdin, Eric Hachulla, Claire Dromer, Ari Chaouat, Martine Reynaud-Gauber, Marie-France Seronde, Hans Klose, Michael Halank, Gert Hoffken, Ralf Ewert, Stephan Rosenkranz, Ekkehard Grunig, Ulrich Kruger, Juliane Kronsbein, Barbara Monika Hauptmeier, Andrea Koch, Matthias Held, Tobias Johannes Lange, Claus Neurohr, Heinrike Wilkens, Hubert Rolf Wilhelm Wirtz, Stavros Konstantinides, Paraskevi Argyropoulou-Pataka, Stylianos Orfanos, Prafulla Gopinath Kerkar, Pujar Venkateshacharya Suresh, Hemang Ashwinkumar Baxi, Abraham Oomman, Rajpal Kanaklal Abhaichand, Padma Kumar Edla Arjun, Vijay Chopra, Rahul Mehrotra, Rajeev Kumar Rajput, Jitendra Pal Singh Sawhney, Subir Bimalendu, Kamal Harishchandra Sharma, Bhagavathula Kutumba Srinivasa Sastry, Mordechai Reuben Kramer, Michael Jonathan Segel, Issahar Ben-Dov, Neville Berkman, Mordechai Yigla, Yochai Adir, Michael D’Alto, Carmine Dario Vizza, Laura Scelsi, Patrizio Vitulo, Tomas Rene Pulido, Anko Boonstra, Madelon Clementina Vonk, Bozena Sobkowicz, Tatiana Mularek-Kubzdela, Adam Torbicki, Piotr Podolec, Lim Soo Teik, Hyuk-Jae Chang, Hyung-Kwan Kim, Jun-Bean Park, Sung-A Chang, Duk-Kyung Kim, Wook-Jin Chung, Jong-Min Song, Magnus Nissell, Clara Hjalmarsson, Bengt Rundqvist, Wei-Chun Huang, Chin-Chang Cheng, Chih-Hsin Hsu, Hsao-Hsun Hsu, Kuo-Yang Wang, John Gerard Coghlan, David Gerard Kiely, Joanna Wanda Pepke-Zaba, James Lawrence Lordan, Paul Anthony Corris, Linda Cadaret, Sif Hansdottir, Ronald Jack Oudiz, David B. Badesch, Michael Mathier, Robert Schilz, Nicholas Hill, Aaron Waxman, Catherine J. Markin, Diane Lynn Zwicke, Micah Fisher, Veronica Franco, Namita Sood, Myung H. Park, Roblee Allen, Jeremy P. Feldman, Vijay Balasubramanian, Vandana Kavita Seeram, Abubakr Bajwa, Austin B. Thompson, Christina Migliore, Jean Elwing, John W. McConnell, Jinesh P. Mehta, Franck Farzad Rahaghi, J. Eduardo Rame, Bela Patel, Ron M. Oren, James R. Klinger, Hassan Alnuaimat, Samuel Allen, William Harvey, Michael S. Eggert, Antoine Hage, Chad E. Miller, Rana Lee Adawi Awdish, Hector Cajigas, Daniel Grinnan, Benjamin Howard Trichon, Clark McDonough, Franz Rischard

Publikováno v: White, R J, Jerjes-Sanchez, C, Bohns Meyer, G M, Pulido, T, Sepulveda, P, Wang, K Y, Grünig, E, Hiremath, S, Yu, Z, Gangcheng, Z, Yip, W L J, Zhang, S, Khan, A, Deng, C Q, Grover, R, Tapson, V F & FREEDOM-EV 2020, ' Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension : A Double-Blind Placebo-controlled Clinical Trial ', American Journal of Respiratory and Critical Care Medicine, vol. 201, no. 6, pp. 707-717 . https://doi.org/10.1164/rccm.201908-1640OC
American Journal of Respiratory and Critical Care Medicine, 201(6), 707-717. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine
White, R J, Jerjes-Sanchez, C, Meyer, G M B, Pulido, T, Sepulveda, P, Wang, K Y, Grünig, E, Hiremath, S, Yu, Z, Zhang, G, Yip, W L J, Zhang, S, Khan, A, Deng, C Q, Grover, R, Tapson, V F, Svetliza, G N, Lescano, A J, Bortman, G R, Diez, F A, Botta, C E, Fitzgerald, J, Feenstra, E, Kermeen, F D, Keogh, A M, Williams, T J, Yousseff, P P, Ng, B J H, Smallwood, D M N, Dwyer, N B, Brown, M R, Lang, I M, Steringer-Mascherbauer, R, Arakaki, J O, Campos, F, De Amorim Correa, R, De Souza, R, Meyer, G M B, Moreira, M C, Yoo, H, Lapa, M S, Swiston, J, Hirani, N, Mehta, S, Michelakis, E, Sepulveda, P, Zagolin, M, Liu, J, Zhang, S, Pan, L, Chunde, B, Qun, Y, Cheng, X, Yu, Z, Li, X, Hua, Y, Zhang, G, Zhu, X, Chen, Y, Cheng, Z, Yang, Y, Zhou, D, Shen, J, Nielsen-Kudsk, J E, Carlsen, J, Bourdin, A, Hachulla, E, Dromer, C, Chaouat, A, Reynaud-Gauber, M, Seronde, M F, Klose, H, Halank, M, Hoffken, G, Ewert, R, Rosenkranz, S, Grunig, E, Kruger, U, Kronsbein, J, Hauptmeier, B M, Koch, A, Held, M, Lange, T J, Neurohr, C, Wilkens, H, Wirtz, H, Konstantinides, S, Argyropoulou-Pataka, P, Orfanos, S, Hiremath, S, Kerkar, P G, Suresh, P V, Baxi, H A, Oomman, A, Abhaichand, R K, Edla Kumar, P K, Chopra, V, Mehrotra, R, Rajput, R K, Sawhney, J S, Bimalendu, S, Sharma, K H, Srinivasa Sastry, B K, Kramer, M R, Segel, M J, Ben-Dov, I, Berkman, N, Yigla, M, Adir, Y, D'Alto, M, Vizza, C D, Scelsi, L, Vitulo, P, Pulido, T R, Jerjes-Sanchez, C, Boonstra, A, Vonk, M C, Sobkowicz, B, Mularek-Kubzdela, T, Torbicki, A, Podolec, P, Teik, L S, Yip, W L J, Chang, H J, Kim, H K, Park, J B, Chang, S A, Kim, D K, Chung, W J, Song, J M, Nissell, M, Hjalmarsson, C, Rundqvist, B, Huang, W C, Cheng, C C, Hsu, C H, Hsu, H H, Wang, K Y, Coghlan, J G, Kiely, D G, Pepke-Zaba, J W, Lordan, J L, Corris, P A, Cadaret, L, Hansdottir, S, Oudiz, R J, Badesch, D B, Mathier, M, Schilz, R, Hill, N, Waxman, A, Markin, C J, Zwicke, D L, Fisher, M, Franco, V, Sood, N, Park, M H, Allen, R, Feldman, J P, Balasubramanian, V, Seeram, V K, Bajwa, A, Thompson, A B, Migliore, C, Elwing, J, McConnell, J W, Mehta, J P, Rahaghi, F F, Rame, J E, Khan, A, Patel, B, Oren, R M, Klinger, J R, Alnuaimat, H, Allen, S, Harvey, W, Eggert, M S, Hage, A, Miller, C E, Awdish, R, Cajigas, H, Grinnan, D, Trichon, B H, McDonough, C, White, R J & Rischard, F 2020, ' Combination therapy with oral treprostinil for pulmonary arterial hypertension : A double-blind placebo-controlled clinical trial ', American Journal of Respiratory and Critical Care Medicine, vol. 201, no. 6, pp. 707-717 . https://doi.org/10.1164/rccm.201908-1640OC
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2020, 201 (6), pp.707-717. ⟨10.1164/rccm.201908-1640OC⟩
White, R J, Jerjes-Sanchez, C, Bohns Meyer, G M, Pulido, T, Sepulveda, P, Wang, K Y, Grünig, E, Hiremath, S, Yu, Z, Gangcheng, Z, Yip, W L J, Zhang, S, Khan, A, Deng, C Q, Grover, R, Tapson, V F, FREEDOM-EV Investigators, Svetliza, G N, Lescano, A J, Bortman, G R, Carlsen, J, McDonough, C, White, J R & Rischard, F 2020, ' Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension : A Double-Blind Placebo-controlled Clinical Trial ', American Journal of Respiratory and Critical Care Medicine, vol. 201, no. 6, pp. 707-717 . https://doi.org/10.1164/rccm.201908-1640OC

Rationale: Oral treprostinil improves exercise capacity in patients with pulmonary arterial hypertension (PAH), but the effect on clinical outcomes was unknown.\ud \ud Objectives: To evaluate the effect of oral treprostinil compared with placebo on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247f9389052b9bd4d58d6383633fc9da
https://pure.au.dk/ws/files/220334028/rccm.201908_1640oc.pdf

Association between lung ultrasound findings and invasive exercise haemodynamics in patients with undifferentiated dyspnoea

Autor: Elke, Platz, Allison, Merz, Montane, Silverman, Eldrin, Lewis, John D, Groarke, Aaron, Waxman, David, Systrom

Publikováno v: ESC Heart Failure

Aims Dyspnoea is common in heart failure (HF) but non‐specific. Lung ultrasound (LUS) could represent a non‐invasive tool to detect subclinical pulmonary congestion in patients with undifferentiated dyspnoea. Methods and results We assessed the f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c482c889f4d11f37f1b459ce12165465
https://pubmed.ncbi.nlm.nih.gov/30474936

SERIAL COMPUTED TOMOGRAPHY PULMONARY ARTERIAL MEASUREMENTS PREDICT SURVIVAL IN PULMONARY HYPERTENSION PATIENTS

Autor: Quynh A. Truong, Zachary Lavender, Qing Zhou, Marc Semigran, Jackie Szymonifka, Joseph Negusei, Rajeev Malhotra, Aaron Waxman

Publikováno v: Journal of the American College of Cardiology. 67:1756

We aimed to determine the prognostic value of baseline and serial computed tomography (CT)-based metrics of main pulmonary artery diameter (mPA) and the ratio of mPA to ascending aortic diameter (ratio PA) in patients with pulmonary hypertension (PH)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc0ae325e4f07f1c2b0701d96c0c304a
https://doi.org/10.1016/s0735-1097(16)31757-0