Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Aaron W. Feldman"'
Autor:
Liang Xu, Ilona Christy Unarta, Ji Shin, Floyd E. Romesberg, Rebekah J Karadeema, Jenny Chong, Ramanarayanan Krishnamurthy, Wei Wang, Jun Xu, Xuhui Huang, Aaron W. Feldman, Dong Wang, Juntaek Oh
Publikováno v:
Nature chemical biology
The development of unnatural base pairs (UBPs) has greatly increased the information storage capacity of DNA, allowing for transcription of unnatural RNA by the heterologously expressed T7 RNA polymerase (RNAP) in Escherichia coli. However, little is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72fc0b4b4683944225a90930c3ebb636
http://europepmc.org/articles/PMC8319059
http://europepmc.org/articles/PMC8319059
Autor:
Ramanarayanan Krishnamurthy, Koji Hashimoto, Emil C. Fischer, Rebekah J Karadeema, Yorke Zhang, Aaron W. Feldman, Floyd E. Romesberg, Ramkrishna Adhikary, Michael P. Ledbetter, Dien Vivian T
Publikováno v:
Nature chemical biology
Natural organisms use a four-letter genetic alphabet that makes available 64 triplet codons, of which 61 are sense codons used to encode proteins with the 20 canonical amino acids. We have shown that the unnatural nucleotides dNaM and dTPT3 can pair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6550f70e588b59d3893309dbd2c33d9c
http://europepmc.org/articles/PMC7263176
http://europepmc.org/articles/PMC7263176
Publikováno v:
J Am Chem Soc
We have created a bacterial semi-synthetic organism (SSO) that retains an unnatural base pair (UBP) in its DNA, transcribes it into mRNA and tRNA with cognate unnatural codons and anticodons, and after the tRNA is charged with a non-canonical amino a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44c7480bf407363ee4642649faed705
https://doi.org/10.1021/jacs.9b09080
https://doi.org/10.1021/jacs.9b09080
Autor:
Ramanarayanan Krishnamurthy, Yanbo You, Aaron W. Feldman, Floyd E. Romesberg, Jason S. Chen, Rebekah J Karadeema, Dien Vivian T, Lingjun Li, Emil C. Fischer, Brooke A. Anderson
Publikováno v:
J Am Chem Soc
Previously, we reported the creation of a semi-synthetic organism (SSO) that stores and retrieves increased information by virtue of stably maintaining an unnatural base pair (UBP) in its DNA, transcribing the corresponding unnatural nucleotides into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fe97814940514bb840938197d19705
https://doi.org/10.1021/jacs.9b02075
https://doi.org/10.1021/jacs.9b02075
Autor:
John C. Chaput, Michael P. Ledbetter, Floyd E. Romesberg, Emil C. Fischer, Jen-Yu Liao, Aaron W. Feldman
Publikováno v:
Journal of the American Chemical Society, vol 140, iss 4
Nucleoside triphosphates play a central role in biology, but efforts to study these roles have proven difficult because the levels of triphosphates are tightly regulated in a cell and because individual triphosphates can be difficult to label or modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2157dba72578f3975e9ceb2c7eec6d50
https://doi.org/10.1021/jacs.7b11404
https://doi.org/10.1021/jacs.7b11404
Autor:
Floyd E. Romesberg, Aaron W. Feldman
Publikováno v:
Journal of the American Chemical Society. 139:11427-11433
In an effort to expand the genetic alphabet and create semi-synthetic organisms (SSOs) that store and retrieve increased information, we have developed the unnatural base pairs (UBPs) dNaM and d5SICS or dTPT3 (dNaM-d5SICS and dNaM-dTPT3). The UBPs fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd085c4208f2acdebeee9921d1b462d5
https://doi.org/10.1021/jacs.7b03540
https://doi.org/10.1021/jacs.7b03540
Publikováno v:
ACS Synthetic Biology. 6:1834-1840
To bestow cells with novel forms and functions, the goal of synthetic biology, we have developed the unnatural nucleoside triphosphates dNaMTP and dTPT3TP, which form an unnatural base pair (UBP) and expand the genetic alphabet. While the UBP may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c100797956268294e29d3b7773efd6
https://doi.org/10.1021/acssynbio.7b00115
https://doi.org/10.1021/acssynbio.7b00115
Autor:
Floyd E. Romesberg, Tammy J. Dwyer, Matthew Holcomb, Emil C. Fischer, Dien Vivian T, Aaron W. Feldman
We have developed a family of unnatural base pairs (UBPs), exemplified by the pair formed between dNaM and dTPT3, for which pairing is mediated not by complementary hydrogen bonding, but by hydrophobic and packing forces. These UBPs enabled the creat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529d6ffcc9b698964977082f4e6dc708
https://europepmc.org/articles/PMC6373772/
https://europepmc.org/articles/PMC6373772/
Autor:
Floyd E. Romesberg, Aaron W. Feldman
Publikováno v:
Accounts of Chemical Research
Conspectus The information available to any organism is encoded in a four nucleotide, two base pair genetic code. Since its earliest days, the field of synthetic biology has endeavored to impart organisms with novel attributes and functions, and perh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf445e997029e8a4590680b7c4d6544
https://pubmed.ncbi.nlm.nih.gov/29198111
https://pubmed.ncbi.nlm.nih.gov/29198111
Autor:
Yorke Zhang, Floyd E. Romesberg, Court R. Turner, Kristine M. San Jose, Ptacin Jerod, Hans R. Aerni, Emil C. Fischer, Aaron W. Feldman, Caffaro Carolina E
Publikováno v:
Nature
Since at least the last common ancestor of all life on Earth, genetic information has been stored in a four-letter alphabet that is propagated and retrieved by the formation of two base pairs. The central goal of synthetic biology is to create new li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdf92c14a8c16c93362de3b3dd25ba5
https://pubmed.ncbi.nlm.nih.gov/29189787
https://pubmed.ncbi.nlm.nih.gov/29189787