Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Aaron T. Whiteley"'
Autor:
Bret N. Peterson, Megan K. M. Young, Shukun Luo, Jeffrey Wang, Aaron T. Whiteley, Joshua J. Woodward, Liang Tong, Jue D. Wang, Daniel A. Portnoy
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT The facultative intracellular pathogen Listeria monocytogenes, like many related Firmicutes, uses the nucleotide second messenger cyclic di-AMP (c-di-AMP) to adapt to changes in nutrient availability, osmotic stress, and the presence of cell
Externí odkaz:
https://doaj.org/article/fda165a1b7c14027812eb73e6e1bcba5
Autor:
Jonathan L. Portman, Samuel B. Dubensky, Bret N. Peterson, Aaron T. Whiteley, Daniel A. Portnoy
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT Upon entry into the host cell cytosol, the facultative intracellular pathogen Listeria monocytogenes coordinates the expression of numerous essential virulence factors by allosteric binding of glutathione (GSH) to the Crp-Fnr family transcri
Externí odkaz:
https://doaj.org/article/0450fd164b444d849a55969f36405c99
Autor:
Chelsea E. Witte, Aaron T. Whiteley, Thomas P. Burke, John-Demian Sauer, Daniel A. Portnoy, Joshua J. Woodward
Publikováno v:
mBio, Vol 4, Iss 3 (2013)
ABSTRACT Listeria monocytogenes infection leads to robust induction of an innate immune signaling pathway referred to as the cytosolic surveillance pathway (CSP), characterized by expression of beta interferon (IFN-β) and coregulated genes. We previ
Externí odkaz:
https://doaj.org/article/494b505188234fde880cd6ecca82a394
Autor:
Hannah E. Ledvina, Qiaozhen Ye, Yajie Gu, Ashley E. Sullivan, Yun Quan, Rebecca K. Lau, Huilin Zhou, Kevin D. Corbett, Aaron T. Whiteley
Publikováno v:
Nature. 616:319-325
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04b9964f56084e6c3d1e8986bda7dd53
https://doi.org/10.1038/s41586-022-05647-4
https://doi.org/10.1038/s41586-022-05647-4
Autor:
Emily M. Kibby, Amy N. Conte, A. Maxwell Burroughs, Toni A. Nagy, Jose A. Vargas, Lindsay A. Whalen, L. Aravind, Aaron T. Whiteley
Publikováno v:
Cell. 186:2410-2424.e18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cb88e2e2b98fa882c0648fff4f89c27
https://doi.org/10.1016/j.cell.2023.04.015
https://doi.org/10.1016/j.cell.2023.04.015
Autor:
Hannah E. Ledvina, Qiaozhen Ye, Yajie Gu, Ashley E. Sullivan, Yun Quan, Rebecca K. Lau, Huilin Zhou, Kevin D. Corbett, Aaron T. Whiteley
Publikováno v:
Nature. 615:E25-E25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33b60b0c97236194fc60a16c0c4feeb9
https://doi.org/10.1038/s41586-023-05931-x
https://doi.org/10.1038/s41586-023-05931-x
Autor:
Hannah E. Ledvina, Qiaozhen Ye, Yajie Gu, Yun Quan, Rebecca K. Lau, Huilin Zhou, Kevin D. Corbett, Aaron T. Whiteley
In all organisms, innate immune pathways sense viral infection and rapidly activate potent immune responses while maintaining a high degree of specificity to prevent inappropriate activation (autoimmunity). In humans, the innate-immune receptor cGAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::100a28841aab95e6fa78db635befee40
https://doi.org/10.1101/2022.03.31.486616
https://doi.org/10.1101/2022.03.31.486616
Autor:
Aaron T. Whiteley, E.A. Nieminen, James B. Eaglesham, B. Lowey, John J. Mekalanos, Olga Danilchanka, Philip J. Kranzusch, B.R. Morehouse, David S. King, C.C. de Oliveira Mann, Amy S. Lee
Publikováno v:
Nature
Cyclic dinucleotides (CDNs) have central roles in bacterial homeostasis and virulence by acting as nucleotide second messengers. Bacterial CDNs also elicit immune responses during infection when they are detected by pattern-recognition receptors in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28215a1a1ff4a4cddb10d5e9a7a2b91
http://europepmc.org/articles/PMC6544370
http://europepmc.org/articles/PMC6544370
Autor:
Emily Kibby, Aaron T. Whiteley
Publikováno v:
J Bacteriol
Nucleotide-activated effector deployment, prototyped by interferon-dependent immunity, is a common mechanistic theme shared by immune systems of several animals and prokaryotes. Prokaryotic versions include CRISPR-Cas with the CRISPR polymerase domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f3af2146dc3947040f5992fc0300b1
https://europepmc.org/articles/PMC7685558/
https://europepmc.org/articles/PMC7685558/
Autor:
Katlynn Bugda Gwilt, John J. Mekalanos, Denis Chang, Wayne I. Lencer, Jay R. Thiagarajah, Aaron T. Whiteley
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Cyclic dinucleotides (CDNs) are important signaling molecules that are involved in many microbial processes and in the host cell response to intracellular pathogens. Intracellular CDN signaling is mediated by well-described sensor protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934edc0c166fa235a5f519690424586a
https://pubmed.ncbi.nlm.nih.gov/33087577
https://pubmed.ncbi.nlm.nih.gov/33087577