Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Aaron T Cheng"'
Autor:
Xiaofeng Xin, David Gfeller, Jackie Cheng, Raffi Tonikian, Lin Sun, Ailan Guo, Lianet Lopez, Alevtina Pavlenco, Adenrele Akintobi, Yingnan Zhang, Jean‐François Rual, Bridget Currell, Somasekar Seshagiri, Tong Hao, Xinping Yang, Yun A Shen, Kourosh Salehi‐Ashtiani, Jingjing Li, Aaron T Cheng, Dryden Bouamalay, Adrien Lugari, David E Hill, Mark L Grimes, David G Drubin, Barth D Grant, Marc Vidal, Charles Boone, Sachdev S Sidhu, Gary D Bader
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp n/a-n/a (2013)
Src homology 3 (SH3) domains bind peptides to mediate protein–protein interactions that assemble and regulate dynamic biological processes. We surveyed the repertoire of SH3 binding specificity using peptide phage display in a metazoan, the worm Ca
Externí odkaz:
https://doaj.org/article/fcff853d9bf24f249607d4cc31797396
Publikováno v:
Genome Editing in Drug Discovery. :47-59
Autor:
Marcel Paulmann, Gerard Joberty, Aaron T. Cheng, Maria Fälth-Savitski, Paola Grandi, Carola Doce, Markus Bösche, Gerard Drewes
Publikováno v:
The CRISPR Journal
CRISPR/Cas9–based gene knockouts (KOs) enable precise perturbation of target gene function in human cells, which is ideally assessed in an unbiased fashion by molecular omics readouts. Typically, this requires the lengthy process of isolating KO su
Autor:
Cassie Messenger, Laurie J. Gordon, Simon C. C. Lucas, Aaron T. Cheng, Kelly M Gatfield, John P. Evans, Emma J. Jones, Mahnoor Mahmood, Charles S. Lay, Charlotte E. Carver, Douglas Sammon, Antonia J. Lewis, Alexander N Phillipou, Syandan Chakraborty, Luke A Greenhough, Peter D. Craggs, David J Brierley
Publikováno v:
SLAS discovery : advancing life sciences RD. 25(2)
Malfunctions in the basic epigenetic mechanisms such as histone modifications, DNA methylation, and chromatin remodeling are implicated in a number of cancers and immunological and neurodegenerative conditions. Within GlaxoSmithKline (GSK) we have ut
Autor:
Daphné Dambournet, Matthew Akamatsu, Kem A. Sochacki, Justin W. Taraska, Dirk Hockemeyer, David G. Drubin, Aaron T. Cheng
Publikováno v:
The Journal of Cell Biology
The Journal of cell biology, vol 217, iss 9
The Journal of cell biology, vol 217, iss 9
Dambournet et al. generate genome-edited human embryonic stem cells (hESCs) labeled with endocytic markers. They comparatively and quantitatively analyze the dynamics of clathrin-mediated endocytosis during differentiation through live-cell imaging a
Autor:
Yannick Doyon, Aaron T. Cheng, Philip D. Gregory, Edward J. Rebar, Jeffrey B. Doyon, Thuy D Vo, Jackie Cheng, Bryan Zeitler, David G. Drubin, David Paschon, Fyodor D. Urnov, Lei Zhang, Jeffrey C. Miller, Jennifer M. Cherone, Andrew H. Lee, Yolanda Santiago
Publikováno v:
Nature Cell Biology. 13:331-337
Clathrin-mediated endocytosis (CME) is the best-studied pathway by which cells selectively internalize molecules from the plasma membrane and surrounding environment. Previous live-cell imaging studies using ectopically overexpressed fluorescent fusi
Publikováno v:
Molecular Biology of the Cell. 20:4640-4651
Recent studies have revealed the detailed timing of protein recruitment to endocytic sites in budding yeast. However, little is understood about the early stages of their formation. Here we identify the septin-associated protein Syp1p as a component
Autor:
Fan Zhang, Sun Hae Hong, David M. Briner, Aaron T. Cheng, Alexandre Grassart, David G. Drubin, Nathan Zenzer, Gregory D. Davis, Dmitry Malkov, Yongmei Feng
Publikováno v:
The Journal of cell biology, vol 205, iss 5
The Journal of Cell Biology
The Journal of Cell Biology
Actin assembly influences the precise temporal and quantitative recruitment of dynamin2 to sites of clathrin-mediated endocytosis.
Clathrin-mediated endocytosis (CME) involves the recruitment of numerous proteins to sites on the plasma membrane
Clathrin-mediated endocytosis (CME) involves the recruitment of numerous proteins to sites on the plasma membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f48c070035bf91cddb4c73581861c8c
https://escholarship.org/uc/item/0dg481pf
https://escholarship.org/uc/item/0dg481pf
Publikováno v:
eLife, vol 2, iss 2
eLife, Vol 2 (2013)
eLife, Vol 2 (2013)
Type II CRISPR immune systems in bacteria use a dual RNA-guided DNA endonuclease, Cas9, to cleave foreign DNA at specific sites. We show here that Cas9 assembles with hybrid guide RNAs in human cells and can induce the formation of double-strand DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31290435fe7bd8812198013eb588fd46
https://escholarship.org/uc/item/996638nr
https://escholarship.org/uc/item/996638nr