Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Aaron Sweeney"'
Autor:
Andriy Kryshtafovych, Maciej Antczak, Marta Szachniuk, Rachael C. Kretsch, Ramya Rangan, Phillip Pham, Rhiju Das, Xavier Robin, Gabriel Studer, Janani Durairaj, Jerome Eberhardt, Aaron Sweeney, Maya Topf, Torsten Schwede, Krzysztof Fidelis, John Moult
Prediction categories in the Critical Assessment of Structure Prediction (CASP) experiments change with the need to address specific problems in structure modeling. In CASP15, four new prediction categories were introduced: RNA structure, ligand-prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e34d47cd362304b547f57c0c364fba6
https://doi.org/10.22541/au.168371643.39402261/v1
https://doi.org/10.22541/au.168371643.39402261/v1
The rapid advancement of the “resolution revolution” has propelled cryo-electron microscopy (cryo-EM) to the forefront of structure-based drug discovery. However, the majority of cryo-EM structures are solved at medium resolution (3-4Å), an unex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::353aecfa96761a848811284a24b1ecbb
https://doi.org/10.1101/2023.03.13.532279
https://doi.org/10.1101/2023.03.13.532279
Autor:
Joseph George Beton, Tristan Cragnolini, Manaz Kaleel, Thomas Mulvaney, Aaron Sweeney, Maya Topf
Publikováno v:
WIREs Computational Molecular Science. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f2616c99328696d9e02dd84ced0f490
https://doi.org/10.1002/wcms.1642
https://doi.org/10.1002/wcms.1642
Publikováno v:
ACS chemical neuroscience. 13(12)
Quinolone antibiotics disrupt bacterial DNA synthesis by interacting with DNA gyrase and topoisomerase IV. However, in addition, they have been shown to act as inhibitors of pentameric ligand-gated ion channels such as GABA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f35feb4926c9876578b7a98c5e775d
https://pubmed.ncbi.nlm.nih.gov/35657695
https://pubmed.ncbi.nlm.nih.gov/35657695
The U.S. National Oceanic and Atmospheric Administration (NOAA) National Centers for Environmental Information (NCEI) archives analog and digital coastal water level data and ocean-bottom pressure data, digitizes select analog data, and performs qual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6b827babb27bfca336e4a1d25094a05
https://doi.org/10.5194/egusphere-egu21-8027
https://doi.org/10.5194/egusphere-egu21-8027
Autor:
Agnel Praveen Joseph, Sony Malhotra, Harpal Sahota, Aaron Sweeney, Daven Vasishtan, Tristan Cragnolini, Maya Topf
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
TEMPy2, an update of the TEMPy package to process, optimize and assess cryo-EM maps and the structures fitted to them, is presented.
Structural determination of molecular complexes by cryo-EM requires large, often complex processing of the image
Structural determination of molecular complexes by cryo-EM requires large, often complex processing of the image
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf3b65f4a5f3eafbec9bc2de09e10ae
https://eprints.bbk.ac.uk/id/eprint/42601/1/42601.pdf
https://eprints.bbk.ac.uk/id/eprint/42601/1/42601.pdf
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2215
The resolving power of cryo-EM experiments has dramatically improved in recent years. However, many cryo-EM maps may still not achieve a resolution that is sufficiently high to allow model building directly from the map. Instead, it is common practic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b7c9eea1c8ae674dcfda2d4f2019f17
https://pubmed.ncbi.nlm.nih.gov/33368005
https://pubmed.ncbi.nlm.nih.gov/33368005
Publikováno v:
cryoEM ISBN: 9781071609651
The resolving power of cryo-EM experiments has dramatically improved in recent years. However, many cryo-EM maps may still not achieve a resolution that is sufficiently high to allow model building directly from the map. Instead, it is common practic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbf80db6db76208a55cb35e833c6d4cd
https://doi.org/10.1007/978-1-0716-0966-8_9
https://doi.org/10.1007/978-1-0716-0966-8_9
The new Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a zoonotic pathogen that has rapidly mutated and become transmissible to humans. There is little existing data on the mutations in SARS-CoV-2 and the impact of these polymorphism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4400c836c83590d2f90ba071e81e1810
https://doi.org/10.1101/2020.09.02.280529
https://doi.org/10.1101/2020.09.02.280529
Publikováno v:
Structure(London, England:1993)
Summary Kinesin-5 motors are vital mitotic spindle components, and disruption of their function perturbs cell division. We investigated the molecular mechanism of the human kinesin-5 inhibitor GSK-1, which allosterically promotes tight microtubule bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78a108ca1fdf1d851fbeb620925a264
https://eprints.bbk.ac.uk/id/eprint/30609/8/30609a.pdf
https://eprints.bbk.ac.uk/id/eprint/30609/8/30609a.pdf