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pro vyhledávání: '"Aaron Shaykevich"'
Autor:
Alexander Siegman, Aaron Shaykevich, Danbee Chae, Isaac Silverman, Sanjay Goel, Radhashree Maitra
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 7530-7547 (2024)
The KRAS gene is mutated in approximately 45% of colorectal cancer patients. There are currently very few targeted treatments or therapies equipped to directly inhibit KRAS due to its unusual structural intricacies. Erlotinib, an EGFR inhibitor, has
Externí odkaz:
https://doaj.org/article/08004cdcbccf45a08d50130a8c2da875
Autor:
Isaac Silverman, Michael Gerber, Aaron Shaykevich, Yitzchak Stein, Alexander Siegman, Sanjay Goel, Radhashree Maitra
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
The RAS genes which code for KRAS, HRAS, and NRAS are three of the most frequently mutated oncogenes responsible for cancer deaths. Tumorigenesis is one of the most significant outcomes of deregulation of RAS GTPases. Although the structures have bee
Externí odkaz:
https://doaj.org/article/6481bb380a4948d9adcd0c40198428e7
Publikováno v:
International Journal of Molecular Sciences. 24:2869
BRG1 is one of two catalytic subunits of the SWI/SNF ATP-dependent chromatin-remodeling complex. In cancer, it has been hypothesized that BRG1 acts as a tumor suppressor. Further study has shown that, under certain circumstances, BRG1 acts as an onco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd0a06cf6430c40098c33b04e14e4500
https://doi.org/10.3390/ijms24032869
https://doi.org/10.3390/ijms24032869