Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Aaron Sha"'
Autor:
Alexander Siegman, Aaron Shaykevich, Danbee Chae, Isaac Silverman, Sanjay Goel, Radhashree Maitra
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 7530-7547 (2024)
The KRAS gene is mutated in approximately 45% of colorectal cancer patients. There are currently very few targeted treatments or therapies equipped to directly inhibit KRAS due to its unusual structural intricacies. Erlotinib, an EGFR inhibitor, has
Externí odkaz:
https://doaj.org/article/08004cdcbccf45a08d50130a8c2da875
Autor:
Isaac Silverman, Michael Gerber, Aaron Shaykevich, Yitzchak Stein, Alexander Siegman, Sanjay Goel, Radhashree Maitra
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
The RAS genes which code for KRAS, HRAS, and NRAS are three of the most frequently mutated oncogenes responsible for cancer deaths. Tumorigenesis is one of the most significant outcomes of deregulation of RAS GTPases. Although the structures have bee
Externí odkaz:
https://doaj.org/article/6481bb380a4948d9adcd0c40198428e7
Autor:
Victoria Diamond, Katherine Gerber, Geno Merli, Rebecca Mercier, Aaron Shafer, Norman Rosenblum
Publikováno v:
Gynecologic Oncology Reports, Vol 56, Iss , Pp 101535- (2024)
Objective: A recent clinical trial demonstrated that the use of apixaban was safe and equal to enoxaparin (LMWH) in post-operative gynecologic oncology patients. This study aimed to determine if these findings are applicable in a diverse patient popu
Externí odkaz:
https://doaj.org/article/57c0a944c59143aebf5e9572b659975c
Autor:
Rita Humeniuk, Kavita Juneja, Shuguang Chen, Scott Ellis, Olena Anoshchenko, Deqing Xiao, Aaron Share, Matthew Johnston, Santosh Davies, Adam DeZure, Joe Llewellyn, Anu Osinusi, Helen Winter, Sandhya Girish, Ramesh Palaparthy, Mark Dresser
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 11, Pp 2276-2288 (2023)
Abstract Intravenous remdesivir (RDV) is US Food and Drug Administration–approved for hospitalized and nonhospitalized individuals with coronavirus disease 2019. RDV undergoes intracellular metabolic activation to form the active triphosphate, GS
Externí odkaz:
https://doaj.org/article/ab437c86ec334aa9a0a440c7bdc247ab
Autor:
Maryam Soleimani, Jennifer L. Spratlin, Shirin Abadi, Sharlene Gill, Karen E. Mulder, Aaron Sha, Winson Y. Cheung, Maria Yi Ho, Jonathan M. Loree, Hagen F. Kennecke
Publikováno v:
Clinical Colorectal Cancer. 17:156-163
710 Background: CAPOX and FOLFOX are used interchangeably in the adjuvant treatment of colon cancer despite the lack of comparative phase III trials.We aimed to compare toxicities, relative dose intensity (RDI), disease free (DFS) and overall surviva
Publikováno v:
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 24(7)
Purpose First, to assess drug utilization rates of capecitabine plus oxaliplatin (CAPOX) versus 5-fluorouracil plus oxaliplatin (mFOLFOX6) regimens in the treatment of stage IIB and stage III colon cancer. Second, to assess patient characteristics us
Autor:
Xiaohui Tao, Aaron Shannon-Honson, Patrick Delaney, Lin Li, Christopher Dann, Yan Li, Haoran Xie
Publikováno v:
IEEE Access, Vol 10, Pp 103176-103186 (2022)
In large MOOC cohorts, the sheer variance and volume of discussion forum posts can make it difficult for instructors to distinguish nuanced emotion in students, such as engagement levels or stress, purely from textual data. Sentiment analysis has bee
Externí odkaz:
https://doaj.org/article/0481dabe687444b4a66e4f1ab4e47c35
Autor:
Xiaohui Tao, Aaron Shannon-Honson, Patrick Delaney, Christopher Dann, Haoran Xie, Yan Li, Shirley O'Neill
Publikováno v:
Computers and Education: Artificial Intelligence, Vol 4, Iss , Pp 100116- (2023)
Online learning and teaching increased in 2020, driven by the COVID-19 pandemic. As many researchers attempted to understand the impact stress had on the emotional behaviours and academic performance of students, most studies explored these pre- and
Externí odkaz:
https://doaj.org/article/80a36ab363af491f90eaa61a769f2dd8
Autor:
Michael Ireland, Michelle Engel, Sonja March, Sonali Parmar, Bonnie Clough, Aaron Sharp, Lauren Moses
Publikováno v:
Asia Pacific Journal of Health Management, Vol 17, Iss 2 (2022)
Health workforce shortages worldwide are approaching crisis point, further burdening systems already struggling to meet demand. Doctor attrition has been identified as a major contributor to this problem and therefore, the current study examined link
Externí odkaz:
https://doaj.org/article/fa3539207deb47a4b3fd8f7db5be9f9a
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2869 (2023)
BRG1 is one of two catalytic subunits of the SWI/SNF ATP-dependent chromatin-remodeling complex. In cancer, it has been hypothesized that BRG1 acts as a tumor suppressor. Further study has shown that, under certain circumstances, BRG1 acts as an onco
Externí odkaz:
https://doaj.org/article/d9f93fc7f2574af4a62f437d403dc345