Cross-Pharma Collaboration for the Development of a Simulation Tool for the Model-Based Digital Design of Pharmaceutical Crystallization Processes (CrySiV)

Autor: Nandkishor K. Nere, Daniel Patience, Aaron S. Cote, Yiqing Claire Liu, Moussa Boukerche, Iben Østergaard, Daniel Pohlman, Eric B. Sirota, Daniel A. Green, Kushal Sinha, Justin L. Quon, Ryan Ellis, Jaron Mackey, Daniel J. Jarmer, Botond Szilagyi, Michael A. Lovette, Huayu Li, Ayse Eren, Zoltan K. Nagy, Wei-Lee Wu, Rahn McKeown, Lorenzo Codan, Erwin Irdam, Shivani Kshirsagar, Kevin P. Girard, Megan Ketchum, Yihui Yang, Haiyan Qu, Christopher S. Polster, Jie Chen, Venkata Ramana Reddy, Emoke Szilagyi, Samir A. Kulkarni, Anna Jawor-Baczynska, Akshay Korde, Laurie Mlinar, Bing-Shiou Yang, Jochen Schoell, Christopher L. Burcham, Jeremy M. Merritt, Simon N. Black

Publikováno v: Szilagyi, B, Wu, W-L, Eren, A, Mackey, J, Kshirsagar, S, Szilagyi, E, Østergaard, I, Qu, H, Sinha, K, Mlinar, L, Pohlman, D, Chen, J, Nere, N, Boukerche, M, Korde, A, Ellis, R, Lovette, M, Black, S, Jawor-Baczynska, A, Li, H, Yang, B-S, Irdam, E, Patience, D, McKeown, R, Ketchum, M, Green, D A, Reddy, V R, Polster, C, Burcham, C, Jarmer, D, Merritt, J M, Cote, A, Sirota, E, Codan, L, Schoell, J, Liu, Y C, Girard, K P, Kulkarni, S A, Yang, Y, Quon, J L & Nagy, Z K 2021, ' Cross-pharma collaboration for the development of a simulation tool for the model-based digital design of pharmaceutical crystallization processes (CrySiV) ', Crystal Growth & Design, vol. 21, no. 11, pp. 6448-6464 . https://doi.org/10.1021/acs.cgd.1c00904

Precompetitive collaborations on new enabling technologies for research and development are becoming popular among pharmaceutical companies. The Enabling Technologies Consortium (ETC), a precompetitive collaboration of leading innovative pharmaceutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c526c98437c173db7499a157af9f261f
https://doi.org/10.1021/acs.cgd.1c00904

Perspectives on the Current State, Challenges, and Opportunities in Pharmaceutical Crystallization Process Development

Autor: Nandkishor K. Nere, Aaron S. Cote, Michael A. Lovette, Kevin P. Girard, Eric B. Sirota, Daniel Albert Green, Deniz Erdemir

Publikováno v: Crystal Growth & Design. 20:7568-7581

Crystallization is the primary process used to purify synthetic drug substances and intermediates as well as to control bulk properties, including particle size, surface area, and flowability. Acco...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::309bd3f58e29e0f96680fc8a5ecca58d
https://doi.org/10.1021/acs.cgd.0c00847

Building a better particle: Leveraging physicochemical understanding of amorphous solid dispersions and a hierarchical particle approach for improved delivery at high drug loadings

Autor: Aaron S. Cote, Andre Hermans, Zhen Liu, Siwei Zhang, Jie Ren, Amanda K. P. Mann, Luke Schenck, Mikolaj Milewski, Kristel Dewitt

Publikováno v: International Journal of Pharmaceutics. 559:147-155

Amorphous solid dispersions are a promising option for managing compounds with poor aqueous solubility. However, for compounds with high melting points, thermal stability limitations, or poor solubility in volatile solvents, conventional routes of ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0707887cd7240ace2d041b93159cac9c
https://doi.org/10.1016/j.ijpharm.2019.01.009

Improving the Filterability of Particles by Healing the Seed Particles

Autor: Aaron S. Cote, Eric B. Sirota, Lorenzo Codan

Publikováno v: Organic Process Research & Development. 22:1131-1142

A shift in particle size distribution toward smaller particle sizes has been observed in batches of Compound A Triethanolate, an isolated intermediate of a commercially available active pharmaceutical ingredient, leading to poor deliquoring of the fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::080f1cdd700dc6789fdb6f6dee5458bd
https://doi.org/10.1021/acs.oprd.8b00150

Determining particle‐size distributions from chord length measurements for different particle morphologies

Autor: Lorenzo Codan, Eric B. Sirota, Jochen Schoell, Roberto Irizarry, Cameron Mengel, Aaron S. Cote

Publikováno v: AIChE Journal. 65:e16560

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af334b54afc463912f1601b039d8ae80
https://doi.org/10.1002/aic.16560