Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Aaron Ruff"'
Autor:
Andreas Blum, Dieter Dorsch, Nina Linde, Susanne Brandstetter, Hans-Peter Buchstaller, Michael Busch, Nina Glaser, Ulrich Grädler, Aaron Ruff, Carl Petersson, Hanno Schieferstein, Eva Sherbetjian, Christina Esdar
Publikováno v:
Journal of Medicinal Chemistry. 66:2386-2395
Autor:
Dieter Dorsch, Nina Glaser, Eva Sherbetjian, Ulrich Graedler, Andreas Blum, Michael Busch, Nina Linde, Carl Petersson, Christina Esdar, Aaron Ruff
Publikováno v:
Cancer Research. 81:1482-1482
Oncogenic mutations in cKIT in exons 9 and 11 are the main driver of gastrointestinal stromal tumors (GIST). Imatinib is standard of care in 1L in unresectable metastatic or recurrent GIST, yet secondary resistance mutations in exons 13/14 and 17/18
Autor:
Shriram M. Pathak, Nikunjkumar Patel, Aaron Ruff, Edmund Kostewicz, Masoud Jamei, David B. Turner
Publikováno v:
Molecular Pharmaceutics. 14:4305-4320
Mechanistic modeling of in vitro data generated from metabolic enzyme systems (viz., liver microsomes, hepatocytes, rCYP enzymes, etc.) facilitates in vitro–in vivo extrapolation (IVIV_E) of metabolic clearance which plays a key role in the success
Autor:
Mark Berlin, Filippos Kesisoglou, Jennifer B. Dressman, Michael Hong Wang, Aaron Ruff, Wei Xu
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 93:267-280
Many active pharmaceutical ingredients (APIs) exhibit a highly variable pharmacokinetic (PK) profile. This behavior may be attributable to pre-absorptive, absorptive and/or post-absorptive factors. Pre-absorptive factors are those related to dosage f
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 105
The present study investigated the ability of the in vitro transfer model and an in vivo pharmacokinetic study in rats to investigate the supersaturation and precipitation behaviour of albendazole (ABZ) relative to data from a human intestinal aspira
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 100
The aim of this study was to optimize the in vitro transfer model and to increase its biorelevance to more accurately mimic the in vivo supersaturation and precipitation behaviour of weak basic drugs. Therefore, disintegration of the formulation, vol
Autor:
Anja Zensi, Vitali Vogel, Thomas Marstaller, Aaron Ruff, Matthias G. Wacker, Jürgen Kufleitner, Jessica Schütz, Tobias Stockburger
Publikováno v:
International Journal of Pharmaceutics. 414:225-232
Nanoparticles consisting of human serum albumin (HSA) play an emerging role in the development of new drug delivery systems. Many of these protein-based colloidal carriers are prepared by the well-known desolvation technique, which has shown to be a