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Akademický článek

From bench to bedside via bytes: Multi-omic immunoprofiling and integration using machine learning and network approaches

Autor: Hanxi Xiao, Aaron Rosen, Prabal Chhibbar, Lenny Moise, Jishnu Das

Publikováno v: Human Vaccines & Immunotherapeutics, Vol 19, Iss 3 (2023)

ABSTRACTA significant surge in research endeavors leverages the vast potential of high-throughput omic technology platforms for broad profiling of biological responses to vaccines and cutting-edge immunotherapies and stem-cell therapies under develop

Externí odkaz: https://doaj.org/article/8bb18e3410fd4b87834c74af00708fb4

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NSG Mice Engrafted with Human PBMC Provide a Robust Platform for Preclinical Testing of Immunomodulatory Therapeutics Relevant to GvHD, Autoimmunity, and Oncology

Autor: Brian Soper, Aaron Rose, Ashley Hodel, Pali Kaur

Publikováno v: The Journal of Immunology. 202:182.67-182.67

NSG mice engraft human PBMC and allow efficacy testing of immunomodulatory drugs in a GvHD setting. Engraftment is progressive and at d5 PBL has 10% human cells with a CD4:CD8 T cell ratio of 3:1. The CD4 cells are 30% CD45RO− CCR7+ naïve (Tn), 40

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5931c82f61fc61de27ccf27db6cd9bc3
https://doi.org/10.4049/jimmunol.202.supp.182.67

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Akademický článek

Photovoltaic technology in Southern Arava of Israel: an analysis of public acceptance

Autor: Thomas DiPersio, Nicoli Liedtke, Aaron Rosenthal, Alexandra Wallace, Avigail Morris, Isa Bar-On, Suleiman Halasah, Tareq Abu Hamed

Publikováno v: International Journal of Sustainable Energy, Vol 40, Iss 1, Pp 85-103 (2021)

Israel's Southern Arava region has experienced a boom in solar infrastructure development since 2011. Public acceptance of renewable energy installations is key to their successful implementation. The objective of this paper is to understand the leve

Externí odkaz: https://doaj.org/article/8b8d2b53d58d4dbe880ddcb47d546587

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Calpastatin prevents NF-κB mediated hyperactivation of macrophages and attenuates colitis (P3151)

Autor: Aaron Rose, Zhi Huang, Fukun Hoffmann, Tobias Denk, Ann Hashimoto, Peter Hoffmann

Publikováno v: The Journal of Immunology. 190:43.37-43.37

Calpain enzymes proteolytically modulate cellular function and have been implicated in inflammatory diseases. In this study, we found that calpain levels did not differ between intestinal tissues from inflammatory bowel disease (IBD) patients and hea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63d45f97307b1aac4b69899ae0c0cbdd
https://doi.org/10.4049/jimmunol.190.supp.43.37

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Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis (P1102)

Autor: Gregory Fredericks, Svenja Meiler, Yvonne Baumer, Zhi Huang, Fukun Hoffmann, Aaron Rose, Robert Norton, William Boisvert, Peter Hoffmann

Publikováno v: The Journal of Immunology. 190:185.26-185.26

Selenoprotein K (Selk) is an endoplasmic reticulum transmembrane protein important for calcium flux and macrophage activation, but its role in foam cell formation and atherosclerosis has not been evaluated. Bone marrow-derived macrophages (BMDM) from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f0767c8f92d064502e4ad2f0edd8879
https://doi.org/10.4049/jimmunol.190.supp.185.26

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Akademický článek

The Hidden Costs of COVID-19 and School Closure on Children

Autor: Aaron Rosenfeld

Publikováno v: University of Ottawa Journal of Medicine, Vol 11, Iss S1 (2021)

An initial public health measure enacted in response to the COVID-19 pandemic was the closure of schools.[1] This action was motivated by previous observations regarding school closure and prevention of pandemic flu transmission.[2,3] In response to

Externí odkaz: https://doaj.org/article/01d147af8b3f4102881408eb1364c57e

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Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by toll-like receptor-induced calpastatin in macrophages (54.22)

Autor: Aaron Rose, Huang Zhi, Fukun Hoffmann, Robert Norton, Peter Hoffamann

Publikováno v: The Journal of Immunology. 188:54.22-54.22

Calpains are calcium (Ca2+)-activated cysteine proteases that modulate cellular function through cleavage of a variety of intra-cellular targets. Two major isoforms of calpain, u- and m-calpain, are expressed in different tissues and cell-types. Sele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6198d8b07aae4a34d2ab3836e688408c
https://doi.org/10.4049/jimmunol.188.supp.54.22

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Calpastatin is a crucial regulator of macrophage activation that limits in vivo inflammation (66.1)

Autor: Peter Hoffmann, Aaron Rose, FuKun Hoffmann, Robert Norton, Zhi Huang

Publikováno v: The Journal of Immunology. 188:66.1-66.1

Calpain enzymes regulate cellular function through the proteolytic modulation of structural and signaling proteins. Calpain activity is positively regulated by the binding of calcium and negatively regulated by the endogenous inhibitor, calpastatin (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef304f0f3db0f9630554b56094105f7b
https://doi.org/10.4049/jimmunol.188.supp.66.1

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