Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Aaron R. Tipton"'
Publikováno v:
Molecular Biology of the Cell
In prophase of meiosis I, homologous chromosomes pair and become connected by cross-overs. Chiasmata, the connections formed by cross-overs, enable the chromosome pair, called a bivalent, to attach as a single unit to the spindle. When the meiotic sp
Autor:
Wenbin Ji, Christopher Arnst, Aaron R Tipton, Michael E Bekier, William R Taylor, Tim J Yen, Song-Tao Liu
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153518 (2016)
OTSSP167 was recently characterized as a potent inhibitor for maternal embryonic leucine zipper kinase (MELK) and is currently tested in Phase I clinical trials for solid tumors that have not responded to other treatment. Here we report that OTSSP167
Externí odkaz:
https://doaj.org/article/f893f3a57572446c808269b6bd7e3f33
In prophase of meiosis I, homologous partner chromosomes pair and become connected by crossovers. Chiasmata, the connections formed between the partners enable the chromosome pair, called a bivalent, to attach as a single unit to the spindle. When th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b044456d1421f7d5b8b758af50332b
https://doi.org/10.1101/2020.06.28.176370
https://doi.org/10.1101/2020.06.28.176370
Publikováno v:
The Journal of Cell Biology
Mitosis involves complex interactions of multiple pathways, some yet uncharacterized. Tipton et al. use bioinformatics to implicate GTSE1 in mitosis. Depletion of GTSE1 disrupts chromosome alignment and spindle pole integrity, in part because of hype
Autor:
Gary J. Gorbsky, Aaron R. Tipton
Publikováno v:
J Cell Sci
The mitotic spindle functions to move chromosomes to alignment at metaphase, then segregate sister chromatids during anaphase. Analysis of spindle microtubule kinetics utilizing fluorescence dissipation after photoactivation described two main popula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b094235d821a373b97ecba5c9884fd1
https://doi.org/10.1101/769752
https://doi.org/10.1101/769752
Publikováno v:
Journal of cancer therapy
Ovarian cancer is the gynecological cancer with the poorest prognosis. One significant reason is the development of resistance to the chemotherapeutic drugs used in its treatment. The large GTPase, hGBP-1, has been implicated in paclitaxel resistance
Publikováno v:
Molecular Biology of the Cell
Cells depleted of Ska arrest at metaphase. Chromosome-associated APC/C shows high ubiquitylation activity. Ska complex helps to localize APC/C on chromosomes. Forced localization of Ska complex to kinetochores enhances APC/C localization to chromosom
Autor:
Melissa J. Philbrick, Song-Tao Liu, Angela F. Messmer-Blust, Aaron R. Tipton, Li Zhang, Jieliang Ma, Yajuan Qi, Jian Li, Shaodong Guo, Jiaping Wu, Hongsheng Liu
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 306:H233-H242
The related transcriptional enhancer factor-1 (RTEF-1) increases gene transcription of hypoxia-inducible factor 1α (HIF-1α) and enhances angiogenesis in endothelium. Both hypoxia and inflammatory factor TNF-α regulate gene expression of HIF-1α, b
Autor:
John P. Wilson, Geoffrey O. Nyabuto, Travis Mazur, Aaron R. Tipton, Jacob S. Justinger, Deborah J. Vestal, Jill A. Trendel, Peter T. Nguyen, Suzan Wadi, Garret L. Moore
Forced expression of the cytokine-induced large GTPase, human Guanylate-Binding Protein-1 (hGBP-1), in ovarian cancer cell lines increases resistance to paclitaxel. Elevated hGBP-1 RNA in ovarian tumors correlates with shorter recurrence-free surviva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cfa0aaa6cee7b2e464c73e6c434a08b
https://europepmc.org/articles/PMC5030188/
https://europepmc.org/articles/PMC5030188/
Autor:
William R. Taylor, Kexi Wang, Michael E. Bekier, Wenbin Ji, Aaron R. Tipton, Brianne Sturt-Gillespie, Song-Tao Liu
MPS1 kinase is an essential component of the spindle assembly checkpoint (SAC), but its functioning mechanisms are not fully understood. We have shown recently that direct interaction between BUBR1 and MAD2 is critical for assembly and function of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776ba971f77d46a252e50364ec8b5eeb
https://europepmc.org/articles/PMC3853266/
https://europepmc.org/articles/PMC3853266/