Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Aaron R Cox"'
Autor:
Peter M Masschelin, Pradip Saha, Scott A Ochsner, Aaron R Cox, Kang Ho Kim, Jessica B Felix, Robert Sharp, Xin Li, Lin Tan, Jun Hyoung Park, Liping Wang, Vasanta Putluri, Philip L Lorenzi, Alli M Nuotio-Antar, Zheng Sun, Benny Abraham Kaipparettu, Nagireddy Putluri, David D Moore, Scott A Summers, Neil J McKenna, Sean M Hartig
Publikováno v:
eLife, Vol 12 (2023)
Flavin adenine dinucleotide (FAD) interacts with flavoproteins to mediate oxidation-reduction reactions required for cellular energy demands. Not surprisingly, mutations that alter FAD binding to flavoproteins cause rare inborn errors of metabolism (
Externí odkaz:
https://doaj.org/article/efada387f39b4eff8fe4ccda1c65b1f6
Autor:
Ayala Tovy, Jaime M Reyes, Linda Zhang, Yung-Hsin Huang, Carina Rosas, Alexes C Daquinag, Anna Guzman, Raghav Ramabadran, Chun-Wei Chen, Tianpeng Gu, Sinjini Gupta, Laura Ortinau, Dongsu Park, Aaron R Cox, Rachel E Rau, Sean M Hartig, Mikhail G Kolonin, Margaret A Goodell
Publikováno v:
eLife, Vol 11 (2022)
DNA Methyltransferase 3 A (DNMT3A) is an important facilitator of differentiation of both embryonic and hematopoietic stem cells. Heterozygous germline mutations in DNMT3A lead to Tatton-Brown-Rahman Syndrome (TBRS), characterized by obesity and exce
Externí odkaz:
https://doaj.org/article/50aa572dd7974a318da9ef564b060f60
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0214829 (2019)
Tamoxifen is a mixed agonist/antagonist estrogen analogue that is frequently used to induce conditional gene deletion in mice using Cre-loxP mediated gene recombination. Tamoxifen is routinely employed in extremely high-doses relative to typical huma
Externí odkaz:
https://doaj.org/article/add5045f70bc482788ab2d59d78b525a
Autor:
Aaron R Cox, Ornella Barrandon, Erica P Cai, Jacqueline S Rios, Julia Chavez, Claire W Bonnyman, Carol J Lam, Peng Yi, Douglas A Melton, Jake A Kushner
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159276 (2016)
The β-cell mitogenic effects of ANGPTL8 have been subjected to substantial debate. The original findings suggested that ANGPTL8 overexpression in mice induced a 17-fold increase in β-cell proliferation. Subsequent studies in mice contested this cla
Externí odkaz:
https://doaj.org/article/b0c7a710f65845308d7de3b10b76ee2f
Autor:
Emily J Shields, Carol J Lam, Aaron R Cox, Matthew M Rankin, Thomas J Van Winkle, Rebecka S Hess, Jake A Kushner
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129809 (2015)
The pathophysiology of canine diabetes remains poorly understood, in part due to enigmatic clinical features and the lack of detailed histopathology studies. Canine diabetes, similar to human type 1 diabetes, is frequently associated with diabetic ke
Externí odkaz:
https://doaj.org/article/5215cc7f5f194ca0b8537dd6afdb0851
Autor:
Yang He, Bas Brouwers, Hesong Liu, Hailan Liu, Katherine Lawler, Edson Mendes de Oliveira, Dong-Kee Lee, Yongjie Yang, Aaron R. Cox, Julia M. Keogh, Elana Henning, Rebecca Bounds, Aliki Perdikari, Vikram Ayinampudi, Chunmei Wang, Meng Yu, Longlong Tu, Nan Zhang, Na Yin, Junying Han, Nikolas A. Scarcelli, Zili Yan, Kristine M. Conde, Camille Potts, Jonathan C. Bean, Mengjie Wang, Sean M. Hartig, Lan Liao, Jianming Xu, Inês Barroso, Jacek Mokrosinski, Yong Xu, I. Sadaf Farooqi
Funder: National Institute for Health Research (NIHR)
Serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and depression. Here we studied the role of the serotonin 2C receptor (5-HT2CR) in weight regulation and
Serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and depression. Here we studied the role of the serotonin 2C receptor (5-HT2CR) in weight regulation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e7fcce37e71b8dfb698909029b7e74
https://www.repository.cam.ac.uk/handle/1810/344906
https://www.repository.cam.ac.uk/handle/1810/344906
Autor:
Peter M. Masschelin, Pradip K. Saha, Scott A. Ochsner, Aaron R. Cox, Kang Ho Kim, Jessica B. Felix, Robert Sharp, Xin Li, Lin Tan, Jun Hyoung Park, Liping Wang, Vasanta Putluri, Philip L. Lorenzi, Alli M. Nuotio-Antar, Zheng Sun, Benny Kaipparettu, Nagireddy Putluri, David D. Moore, Scott A. Summers, Neil J. McKenna, Sean M. Hartig
Flavin adenine dinucleotide (FAD) interacts with flavoproteins to mediate oxidation-reduction reactions required for cellular energy demands. Not surprisingly, mutations that alter FAD binding to flavoproteins cause rare inborn errors of metabolism (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16c5122c34f5efacdeb1777684e399b8
https://doi.org/10.1101/2022.10.16.512439
https://doi.org/10.1101/2022.10.16.512439
Autor:
Ayala Tovy, Jaime M Reyes, Linda Zhang, Yung-Hsin Huang, Carina Rosas, Alexes C Daquinag, Anna Guzman, Raghav Ramabadran, Chun-Wei Chen, Tianpeng Gu, Sinjini Gupta, Laura Ortinau, Dongsu Park, Aaron R Cox, Rachel E Rau, Sean M Hartig, Mikhail G Kolonin, Margaret A Goodell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c37cc490702a8aee597011f2720d4216
https://doi.org/10.7554/elife.72359.sa2
https://doi.org/10.7554/elife.72359.sa2
Autor:
Jerry L. Perrard, Antu Kalathookunnel Antony, Huaizhu Wu, Christie M. Ballantyne, Zeqin Lian, Hua Liu, Lothar Hennighausen, Pradip K. Saha, Xiaoyuan Dai Perrard, Sean M. Hartig, Aaron R. Cox
Publikováno v:
Diabetes. 70:720-732
CD11c+ macrophages/dendritic cells (MDCs) are increased and display the classically activated M1-like phenotype in obese adipose tissue (AT) and may contribute to AT inflammation and insulin resistance. Stat1 is a key transcription factor for MDC pol
Autor:
Sean M. Hartig, Cristian Coarfa, Pradip K. Saha, Jessica B. Felix, Mandeep Bajaj, Vasanta Putluri, Peter M. Masschelin, Aaron R. Cox, Mark P. Hamilton, Nagireddy Putluri, Kimal Rajapakshe
Publikováno v:
Am J Physiol Endocrinol Metab
MicroRNA-30a (miR-30a) impacts adipocyte function, and its expression in white adipose tissue (WAT) correlates with insulin sensitivity in obesity. Bioinformatic analysis demonstrates that miR-30a expression contributes to 2% of all miRNA expression