Výsledky vyhledávání - "Aaron Presser"

Akademický článek

IL15 modification enables CAR T cells to act as a dual targeting agent against tumor cells and myeloid-derived suppressor cells in GBM

Autor: Stephen Gottschalk, Maciej S Lesniak, Irina V Balyasnikova, Jason Miska, Catalina Lee-Chang, Markella Zannikou, Joseph T Duffy, Rebecca N Levine, Maggie Seblani, Qianli Liu, Aaron Presser, Victor A Arrieta, Christopher J Chen, Adam M Sonabend, Craig M Horbinski

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)

Introduction The immunosuppressive tumor microenvironment (TME) is a major barrier to the efficacy of chimeric antigen receptor T cells (CAR-T cells) in glioblastoma (GBM). Transgenic expression of IL15 is one attractive strategy to modulate the TME.

Externí odkaz: https://doaj.org/article/43dc601b223a4474a9f5b2a82d5d8401

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IL15 modification enables CAR T cells to act as a dual targeting agent against tumor cells and myeloid-derived suppressor cells in GBM

Autor: Markella Zannikou, Joseph T Duffy, Rebecca N Levine, Maggie Seblani, Qianli Liu, Aaron Presser, Victor A Arrieta, Christopher J Chen, Adam M Sonabend, Craig M Horbinski, Catalina Lee-Chang, Jason Miska, Maciej S Lesniak, Stephen Gottschalk, Irina V Balyasnikova

Publikováno v: Journal for ImmunoTherapy of Cancer. 11:e006239

IntroductionThe immunosuppressive tumor microenvironment (TME) is a major barrier to the efficacy of chimeric antigen receptor T cells (CAR-T cells) in glioblastoma (GBM). Transgenic expression of IL15 is one attractive strategy to modulate the TME.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81397616a6178e612600c93eccb5ff68
https://doi.org/10.1136/jitc-2022-006239

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