Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Aaron P. Owji"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Bestrophin-1 (Best1) is an anion channel genetically linked to vision-threatening retinal degenerative channelopathies. Here, we identify interactions between Best1 and both isoforms of glutamic acid decarboxylases (GAD65 and GAD67), elucida
Externí odkaz:
https://doaj.org/article/4ac797b8450a49db9b39a38561ffa21c
Autor:
Aaron P. Owji, Jiali Wang, Alec Kittredge, Zada Clark, Yu Zhang, Wayne A. Hendrickson, Tingting Yang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Bestrophin channels are critical for physiology of the eye. Here, authors report cryo-EM structures of human bestrophins in various states at up to 1.8 Å resolution, revealing paralog-specific features that underlie molecular mechanisms of permeatio
Externí odkaz:
https://doaj.org/article/f20545733ff64a9199865a3c3234ef9b
Publikováno v:
Calcium Signals ISBN: 9780750320092
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b32f298b449b3ae72808654c0b225d01
https://doi.org/10.1088/978-0-7503-2009-2ch7
https://doi.org/10.1088/978-0-7503-2009-2ch7
Publikováno v:
Channels
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Bestrophins are a family of calcium-activated chloride channels (CaCCs) with relevance to human physiology and a myriad of eye diseases termed “bestrophinopathies”. Since the identification of bestrophins as CaCCs nearly two decades ago, extensiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a74b6b2127b7032b462c30e272b245
https://doi.org/10.1080/19336950.2021.1981625
https://doi.org/10.1080/19336950.2021.1981625
Autor:
Janet R. Sparrow, Jin Zhao, Tingting Yang, Stephen H. Tsang, Keiko Ueda, Hye Jin Kim, Jose Ronaldo Lima de Carvalho, Aaron P. Owji
Publikováno v:
Journal of Biological Chemistry. 295:6767-6780
Mutations in retinaldehyde-binding protein 1 (RLBP1), encoding the visual cycle protein cellular retinaldehyde-binding protein (CRALBP), cause an autosomal recessive form of retinal degeneration. By binding to 11-cis-retinoid, CRALBP augments the iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c68123d520336caf3a34a550c8707e1
https://doi.org/10.1074/jbc.ra120.012695
https://doi.org/10.1074/jbc.ra120.012695
Publikováno v:
Nature
Bestrophin-2 (Best2) is a member of the bestrophin family of calcium-activated anion channels with critical involvement in ocular physiology(1–4). Here, we uncover a directional permeability of Best2 to glutamate heavily favoring glutamate exit, id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957df93ed8d0326cc12496be8b1b4738
https://pubmed.ncbi.nlm.nih.gov/36289327
https://pubmed.ncbi.nlm.nih.gov/36289327
Autor:
Jose Ronaldo, Lima de Carvalho, Hye Jin, Kim, Keiko, Ueda, Jin, Zhao, Aaron P, Owji, Tingting, Yang, Stephen H, Tsang, Janet R, Sparrow
Publikováno v:
The Journal of Biological Chemistry
Mutations in retinaldehyde-binding protein 1 (RLBP1), encoding the visual cycle protein cellular retinaldehyde-binding protein (CRALBP), cause an autosomal recessive form of retinal degeneration. By binding to 11-cis-retinoid, CRALBP augments the iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b03477bc440a5bd720025a16f2a6bd3f
https://pubmed.ncbi.nlm.nih.gov/32188692
https://pubmed.ncbi.nlm.nih.gov/32188692
Publikováno v:
Biophysical Journal. 121:507a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0a375829a22df2751658e522d05f014
https://doi.org/10.1016/j.bpj.2021.11.252
https://doi.org/10.1016/j.bpj.2021.11.252
Publikováno v:
Biophysical Journal. 121:343a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdd022215997a09fa471542e298c684d
https://doi.org/10.1016/j.bpj.2021.11.1055
https://doi.org/10.1016/j.bpj.2021.11.1055
Autor:
Alec Kittredge, Oliver B. Clarke, Nancy Ward, Aaron P. Owji, Wayne A. Hendrickson, Yu Zhang, Changyi Ji, Austin Hopiavuori, Tingting Yang, Yin Shen, Ziao Fu, Qingqing Zhao
Publikováno v:
Nature structural & molecular biology
The bestrophin family of calcium (Ca2+)-activated chloride (Cl−) channels, which mediate the influx and efflux of monovalent anions in response to the levels of intracellular Ca2+, comprises four members in mammals (bestrophin 1–4). Here we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1604f5d9a781bfc21542f9c33cef0f8e
https://pubmed.ncbi.nlm.nih.gov/32251414
https://pubmed.ncbi.nlm.nih.gov/32251414