Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Aaron P, McGrath"'
Autor:
Jie Yin, Yanyong Kang, Aaron P. McGrath, Karen Chapman, Megan Sjodt, Eiji Kimura, Atsutoshi Okabe, Tatsuki Koike, Yuhei Miyanohana, Yuji Shimizu, Rameshu Rallabandi, Peng Lian, Xiaochen Bai, Mack Flinspach, Jef K. De Brabander, Daniel M. Rosenbaum
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract The OX2 orexin receptor (OX2R) is a highly expressed G protein-coupled receptor (GPCR) in the brain that regulates wakefulness and circadian rhythms in humans. Antagonism of OX2R is a proven therapeutic strategy for insomnia drugs, and agoni
Externí odkaz:
https://doaj.org/article/9405c8a136a547eebb4d8f70de895b56
Autor:
Jie Yin, Yanyong Kang, Aaron P. McGrath, Karen Chapman, Megan Sjodt, Eiji Kimura, Atsutoshi Okabe, Tatsuki Koike, Yuhei Miyanohana, Yuji Shimizu, Rameshu Rallabandi, Peng Lian, Xiaochen Bai, Mack Flinspach, Jef K. De Brabander, Daniel M. Rosenbaum
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/9a0f713de8cb43e89a329843e0e714da
Autor:
Daniel Conde, Brianna Miles, Derek R. Drost, Norman J. Wickett, Matias Kirst, Christina A. Finegan, Matthew G. Johnson, Paul Szewczyk, Geoffrey Chang, Henry W. Schmidt, Timothy A. Martin, Christopher Dervinis, Gary F. Peter, Faride Unda, J. Gordon Burleigh, Carlos A. Gonzalez-Benecke, Shawn D. Mansfield, Aaron P. McGrath, Cíntia L. Ribeiro, Evandro Novaes, Kelly M. Balmant
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Flowering plants exhibit exceptional diversity of form and stature. Their ability to achieve great heights is supported in part by their water-conducting specialized cells, the vessel elements, which have gradually evolved and resulted i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24801628be3587467ef05ba81086b62a
http://europepmc.org/articles/PMC7060721
http://europepmc.org/articles/PMC7060721
Autor:
Aaron P McGrath, Elise L Laming, G Patricia Casas Garcia, Marc Kvansakul, J Mitchell Guss, Jill Trewhella, Benoit Calmes, Paul V Bernhardt, Graeme R Hanson, Ulrike Kappler, Megan J Maher
Publikováno v:
eLife, Vol 4 (2015)
Interprotein electron transfer underpins the essential processes of life and relies on the formation of specific, yet transient protein-protein interactions. In biological systems, the detoxification of sulfite is catalyzed by the sulfite-oxidizing e
Externí odkaz:
https://doaj.org/article/295666060edd460ba12dad15e6907a1a
Autor:
Katherine Ganio, Andrew J. Hayes, Norimichi Nomura, Christopher A. McDevitt, Alex Carey Hulyer, Stephen J. Fairweather, Megan J. Maher, Tess R. Malcolm, Jacinta A. Watts, Aaron P. McGrath, Megan L. O'Mara, So Iwata, Jennie Sjöhamn, Stephanie L. Neville, Mark R. Davies, Hugo MacDermott-Opeskin
Publikováno v:
Science Advances
Bacterial manganese import is achieved by unique architectural features that are conserved across the kingdoms of life.
Metal ions are essential for all forms of life. In prokaryotes, ATP-binding cassette (ABC) permeases serve as the primary imp
Metal ions are essential for all forms of life. In prokaryotes, ATP-binding cassette (ABC) permeases serve as the primary imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325083886c53aa322f6fb09ed239abe3
http://hdl.handle.net/2433/265288
http://hdl.handle.net/2433/265288
Autor:
Koustav Maity, John M. Heumann, Aaron P. McGrath, Noah J. Kopcho, Po-Kai Hsu, Chang-Wook Lee, James H. Mapes, Denisse Garza, Srinivasan Krishnan, Garry P. Morgan, Kevin J. Hendargo, Thomas Klose, Steven D. Rees, Arturo Medrano-Soto, Milton H. Saier, Miguel Piñeros, Elizabeth A. Komives, Julian I. Schroeder, Geoffrey Chang, Michael H. B. Stowell
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 28
Sensing and responding to environmental water deficiency and osmotic stresses are essential for the growth, development, and survival of plants. Recently, an osmolality-sensing ion channel called OSCA1 was discovered that functions in sensing hyperos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e750bb3a934480b2eb32720b7d95240a
https://doi.org/10.1073/pnas.1900774116
https://doi.org/10.1073/pnas.1900774116
Autor:
Steven D. Rees, Sascha C.T. Nicklisch, Geoffrey Chang, Aaron P. McGrath, Amara Pouv, Amro Hamdoun
Publikováno v:
Comparative biochemistry and physiology. Toxicologypharmacology : CBP. 248
Marine pollutants bioaccumulate at high trophic levels of marine food webs and are transferred to humans through consumption of apex species. Yellowfin tuna (Thunnus albacares) are marine predators, and one of largest commercial fisheries in the worl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1af7e200e92933d363a095004e28eb7
https://pubmed.ncbi.nlm.nih.gov/34116183
https://pubmed.ncbi.nlm.nih.gov/34116183
Autor:
Kumar Singh Saikatendu, Hiroshi Imoto, Ikuo Fujimori, Morio Murakami, Atsutoshi Okabe, Tsuyoshi Ishii, Aaron P. McGrath, Hua Zou, Takeshi Wakabayashi
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 49, Pp 31984-32001 (2020)
ACS Omega, Vol 5, Iss 49, Pp 31984-32001 (2020)
Fragment screening is frequently used for hit identification. However, there was no report starting from a small fragment for the development of an anaplastic lymphoma kinase (ALK) inhibitor, despite the number of ALK inhibitors reported. We began ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59aa514c10db11277a9c9db6bc46093a
https://pubmed.ncbi.nlm.nih.gov/33344853
https://pubmed.ncbi.nlm.nih.gov/33344853
Autor:
Mihwa Lee, Farzana Darain, Ulrike Kappler, Megan J. Maher, Jeffrey Harmer, Paul V. Bernhardt, Aaron P. McGrath, Palraj Kalimuthu, Linda Kielmann, Ju-Chun Hsiao, Kimberley Meyers
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1859:19-27
A central conserved arginine, first identified as a clinical mutation leading to sulfite oxidase deficiency, is essential for catalytic competency of sulfite oxidizing molybdoenzymes, but the molecular basis for its effects on turnover and substrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1fb5348e15452ec129ac0a2e501ad7
https://doi.org/10.1016/j.bbabio.2017.10.001
https://doi.org/10.1016/j.bbabio.2017.10.001
Autor:
Srinivasan Krishnan, Milton H. Saier, Noah J. Kopcho, Aaron P. McGrath, Geoffrey Chang, John M. Heumann, Elizabeth A. Komives, Arturo Medrano-Soto, Julian I. Schroeder, Miguel A. Piñeros, Po-Kai Hsu, Michael H. B. Stowell, Koustav Maity
Publikováno v:
Biophysical Journal. 118:211a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48b516489670e5d817c1adcda76da144
https://doi.org/10.1016/j.bpj.2019.11.1262
https://doi.org/10.1016/j.bpj.2019.11.1262