Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Aaron Nilsen"'
Autor:
Haihong Jin, Nicole A. Ladd, Andrew M. Peev, Gwendolyn M. Swarbrick, Meghan Cansler, Megan Null, Christopher T. Boughter, Curtis McMurtrey, Aaron Nilsen, Karen M. Dobos, William H. Hildebrand, Deborah A. Lewinsohn, Erin J. Adams, David M. Lewinsohn, Melanie J. Harriff
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated in early effector responses to microbial infection. As a result, there is considerable inter
Externí odkaz:
https://doaj.org/article/2922d25154b844d9be6d978cad284414
Autor:
Marta G. Silva, Reginaldo G. Bastos, J. Stone Doggett, Michael K. Riscoe, Sovitj Pou, Rolf Winter, Rozalia A. Dodean, Aaron Nilsen, Carlos E. Suarez
Publikováno v:
Parasites & Vectors, Vol 13, Iss 1, Pp 1-11 (2020)
Abstract Background The most common apicomplexan parasites causing bovine babesiosis are Babesia bovis and B. bigemina, while B. caballi and Theileria equi are responsible for equine piroplasmosis. Treatment and control of these diseases are usually
Externí odkaz:
https://doaj.org/article/35a9dec597be472688855738dda6a7d7
Autor:
Martin J. Smilkstein, Sovitj Pou, Alina Krollenbrock, Lisa A. Bleyle, Rozalia A. Dodean, Lisa Frueh, David J. Hinrichs, Yuexin Li, Thomas Martinson, Myrna Y. Munar, Rolf W. Winter, Igor Bruzual, Samantha Whiteside, Aaron Nilsen, Dennis R. Koop, Jane X. Kelly, Stefan H. I. Kappe, Brandon K. Wilder, Michael K. Riscoe
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-17 (2019)
Abstract Background The potential benefits of long-acting injectable chemoprotection (LAI-C) against malaria have been recently recognized, prompting a call for suitable candidate drugs to help meet this need. On the basis of its known pharmacodynami
Externí odkaz:
https://doaj.org/article/630a94e7fc5a4c469f0ed0eacdad2650
Autor:
Jinu Abraham, Sara Botto, Nobuyo Mizuno, Kara Pryke, Bryan Gall, Dylan Boehm, Tina M. Sali, Haihong Jin, Aaron Nilsen, Michael Gough, Jason Baird, Marita Chakhtoura, Caroline Subra, Lydie Trautmann, Elias K. Haddad, Victor R. DeFilippis
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The innate immune response to cytosolic DNA involves transcriptional activation of type I interferons (IFN-I) and proinflammatory cytokines. This represents the culmination of intracellular signaling pathways that are initiated by pattern recognition
Externí odkaz:
https://doaj.org/article/31d8bd92b5c644bc9bd8223516f664ff
Autor:
Naja Eberhard, Vreni Balmer, Joachim Müller, Norbert Müller, Rolf Winter, Soviti Pou, Aaron Nilsen, Mike Riscoe, Samuel Francisco, Alexandre Leitao, J. Stone Doggett, Andrew Hemphill
Publikováno v:
Frontiers in Veterinary Science, Vol 7 (2020)
Endochin-like quinolones (ELQs) potently inhibit the proliferation of Plasmodium, Toxoplasma, Neospora, and Babesia by targeting the cytochrome b Qo and Qi sites and interfering with oxidative phosphorylation and pyrimidine biosynthesis. The activiti
Externí odkaz:
https://doaj.org/article/3018e9a1963f4eb2a00b256113e60aed
4′‐Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN
Autor:
Suh Young Jeong, Penelope Hogarth, Andrew Placzek, Allison M Gregory, Rachel Fox, Dolly Zhen, Jeffrey Hamada, Marianne van der Zwaag, Roald Lambrechts, Haihong Jin, Aaron Nilsen, Jared Cobb, Thao Pham, Nora Gray, Martina Ralle, Megan Duffy, Leila Schwanemann, Puneet Rai, Alison Freed, Katrina Wakeman, Randall L Woltjer, Ody CM Sibon, Susan J Hayflick
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 12, Pp n/a-n/a (2019)
Abstract Pantothenate kinase‐associated neurodegeneration (PKAN) is an inborn error of CoA metabolism causing dystonia, parkinsonism, and brain iron accumulation. Lack of a good mammalian model has impeded studies of pathogenesis and development of
Externí odkaz:
https://doaj.org/article/39dd68cc193f40f0bd70717b8309a877
Autor:
Hangjun Ke, Suresh M Ganesan, Swati Dass, Joanne M Morrisey, Sovitj Pou, Aaron Nilsen, Michael K Riscoe, Michael W Mather, Akhil B Vaidya
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214023 (2019)
The battle against malaria has been substantially impeded by the recurrence of drug resistance in Plasmodium falciparum, the deadliest human malaria parasite. To counter the problem, novel antimalarial drugs are urgently needed, especially those that
Externí odkaz:
https://doaj.org/article/93b12d83f6f74bde8f392ab58d0b99ea
Autor:
Dmitri Rozanov, Anton Cheltsov, Aaron Nilsen, Christopher Boniface, Isaac Forquer, James Korkola, Joe Gray, Jeffrey Tyner, Cristina E Tognon, Gordon B Mills, Paul Spellman
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0205623 (2019)
To determine the target of the recently identified lead compound NSC130362 that is responsible for its selective anti-cancer efficacy and safety in normal cells, structure-activity relationship (SAR) studies were conducted. First, NSC13062 was valida
Externí odkaz:
https://doaj.org/article/725ef1333a644e51a8aca39671124606
Autor:
Nicoleta Anghel, Vreni Balmer, Joachim Müller, Pablo Winzer, Adriana Aguado-Martinez, Mona Roozbehani, Sovitj Pou, Aaron Nilsen, Michael Riscoe, J. Stone Doggett, Andrew Hemphill
Publikováno v:
Frontiers in Veterinary Science, Vol 5 (2018)
We report on the efficacy of selected endochin-like quinolones (ELQs) against N. caninum tachyzoites grown in human foreskin fibroblasts (HFF), and in a pregnant BALB/c mouse model. Fourteen ELQs were screened against transgenic N. caninum tachyzoite
Externí odkaz:
https://doaj.org/article/e77756f34e184cd3b80487fcf8046c1a
Autor:
Kara M. Pryke, Jinu Abraham, Tina M. Sali, Bryan J. Gall, Iris Archer, Andrew Liu, Shelly Bambina, Jason Baird, Michael Gough, Marita Chakhtoura, Elias K. Haddad, Ilsa T. Kirby, Aaron Nilsen, Daniel N. Streblow, Alec J. Hirsch, Jessica L. Smith, Victor R. DeFilippis
Publikováno v:
mBio, Vol 8, Iss 3 (2017)
ABSTRACT The ongoing concurrent outbreaks of Zika, Chikungunya, and dengue viruses in Latin America and the Caribbean highlight the need for development of broad-spectrum antiviral treatments. The type I interferon (IFN) system has evolved in vertebr
Externí odkaz:
https://doaj.org/article/09f2dc17e4774d63a4c91dc285882276