Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Aaron N. Patrick"'
Autor:
Kathryn Packman, Scott D. Kuduk, Xiaochun Zhang, Ulrike Philippar, Yusri Elsayed, Andrew Steele, Jacqueline Bussolari, Weixue Wang, Gilles Bignan, Lindsey G. DeRatt, Kathryn Bradford, Ricardo Attar, Friedericke Pastore, Zhuming Zhang, Nikki Daskalakis, Edgar Jacoby, Christine Pietsch, Tony Greway, James P. Edwards, Aaron N. Patrick, Bush Tammy, Faraz Kazmi
Publikováno v:
Cancer Research. 81:1256-1256
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by uncontrolled clonal expansion of hematopoietic progenitor cells (myeloid blasts). Disease remission can be achieved with standard induction chemotherapy, but refractory and rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed8b93e289be850b8bbe528736bc3583
https://doi.org/10.1158/1538-7445.am2021-1256
https://doi.org/10.1158/1538-7445.am2021-1256
Publikováno v:
Expert Opinion on Therapeutic Targets. 19:213-225
The SIX homeodomain proteins and the eyes absent (EYA) family of co-activators form a bipartite transcription factor complex that promotes the proliferation and survival of progenitor cells during organogenesis and is down-regulated in most adult tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0483be00601aaf4cec57b0b1056349e2
https://doi.org/10.1517/14728222.2014.978860
https://doi.org/10.1517/14728222.2014.978860
Autor:
Stefan Steinbacher, Annie X. Liu, Paul F. Jackson, Marina I. Nelen, Marcos E. Milla, Krystal Herman, Aaron N. Patrick, Jonathan M. Blevitt, Paul J. Krawczuk, Kevin J. Lumb, Alec D. Lebsack, Taraneh Mirzadegan, Michael D. Hack
Publikováno v:
Journal of medicinal chemistry. 60(8)
A prevalent observation in high-throughput screening and drug discovery programs is the inhibition of protein function by small-molecule compound aggregation. Here, we present the X-ray structural description of aggregation-based inhibition of a prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c2452e043c3c88a3cc89cdec313139
https://pubmed.ncbi.nlm.nih.gov/28300404
https://pubmed.ncbi.nlm.nih.gov/28300404
Publikováno v:
Nature structural & molecular biology
SUMMARY SIX1 interacts with EYA to form a bipartite transcription factor essential for development. Loss of function of this complex causes branchio-oto-renal syndrome (BOR), while re-expression of SIX1 or EYA promotes metastasis. Here we describe th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f00450f8efa768f68367275800aaba6
https://doi.org/10.1038/nsmb.2505
https://doi.org/10.1038/nsmb.2505
Publikováno v:
Journal of Biological Chemistry. 284:20781-20790
Branchio-oto-renal syndrome (BOR) is an autosomal dominant developmental disorder characterized by hearing loss, branchial arch defects, and renal anomalies. Recently, eight mutations in the SIX1 homeobox gene were discovered in BOR patients. To char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f861cf4288ffe132e1d2582a10bbc8
https://doi.org/10.1074/jbc.m109.016832
https://doi.org/10.1074/jbc.m109.016832
Autor:
Anya D. Sydlaske, Aaron N. Patrick, Lisa M. Barnhill, Kenneth R. Day, Andrew M. Kropinski, Carly C. Guthrie, Kyle A. Havens, Stephen J. Billington, Darrel R. Falk, Jared A. Guichard, Irina V. Kovalyova, Brent D. Butts, Trevor J. Pitcher, Michael R. McConnell
Publikováno v:
Virology. 369(2):234-244
The genome sequence of the Salmonella enterica serovar Anatum-specific, serotype-converting bacteriophage epsilon15 has been completed. The nonredundant genome contains 39,671 bp and 51 putative genes. It most closely resembles the genome of phiV10,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12f05bbe6af8ff3375b4e3e0e1ec20e
Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration
Autor:
Samarjit Patnaik, David J. Drasin, Philip Reigan, Christopher J. Matheson, Aaron B. Krueger, Heide L. Ford, Noel Southall, Michael J. Holliday, Elan Z. Eisenmesser, Xin Hu, Elena Barnaeva, Rui Zhao, Donald S. Backos, Melanie A. Blevins, Anton Simeonov, Tyler P. Robin, Marc Ferrer, Juan J. Marugan, Aaron N. Patrick, Wendy A. Lea
Publikováno v:
The Journal of biological chemistry. 289(23)
Eya proteins are essential co-activators of the Six family of transcription factors and contain a unique tyrosine phosphatase domain belonging to the haloacid dehalogenase family of phosphatases. The phosphatase activity of Eya is important for the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41ff6594b0fad3b51713b2741192df3
https://pubmed.ncbi.nlm.nih.gov/24755226
https://pubmed.ncbi.nlm.nih.gov/24755226
Autor:
Jennifer I. Crary, Dawn Kohrt, Martha J. Grossel, Marc Zimmer, Heide L. Ford, Aaron N. Patrick, Philip W. Hinds
Publikováno v:
Cell Cycle
Cyclin-dependent kinase 6 (Cdk6) is a D-Cyclin-activated kinase that is directly involved in driving the cell cycle through inactivation of pRB in G1 phase. Increasingly, evidence suggests that CDK6, while directly driving the cell cycle, may only be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e623fb5ec34fbcf024617ff4c3ae7b48
https://pubmed.ncbi.nlm.nih.gov/24196439
https://pubmed.ncbi.nlm.nih.gov/24196439
Autor:
Lubna Qamar, Heide L. Ford, Miriam D. Post, Aaron N. Patrick, Erin Deitsch, Ritsuko Iwanaga, Kian Behbakht, Monique A. Spillman, Andrew Thorburn
The presence of Six1 mRNA gene portends a poor prognosis in ovarian cancer. We describe validation of a Six1 specific antibody and evaluate its association with tumorigenicity and prognosis in ovarian cancer.A Six1 antibody (Six1cTerm) was raised to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2199fd5fcfc3c3667980b0cd19ddb51
https://europepmc.org/articles/PMC3607428/
https://europepmc.org/articles/PMC3607428/
Autor:
J. Chuck Harrell, Erin Deitsch, Chu-An Wang, Matias Casás-Selves, Douglas S. Micalizzi, Paul Jedlicka, Kimberly C. Lemmer, Aaron N. Patrick, Heide L. Ford
Publikováno v:
The Journal of clinical investigation. 122(5)
An association between lymph node metastasis and poor prognosis in breast cancer was observed decades ago. However, the mechanisms by which tumor cells infiltrate the lymphatic system are not completely understood. Recently, it has been proposed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c20e8c5131fe54a9ca3dffbae212c3
https://pubmed.ncbi.nlm.nih.gov/22525572
https://pubmed.ncbi.nlm.nih.gov/22525572