Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Aaron Moment"'
Autor:
Ning Zhang, Aaron Moment
Publikováno v:
ACS Sustainable Chemistry & Engineering. 11:866-879
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dcf5ea78aed8a5c587f6deb060b31ab
https://doi.org/10.1021/acssuschemeng.2c04241
https://doi.org/10.1021/acssuschemeng.2c04241
Autor:
Peter E. Maligres, Feng Peng, Ralph Calabria, Louis-Charles Campeau, Wenyong Chen, Peter G. Dormer, Meredith Green, Cyndi Qixin He, Alan M. Hyde, Artis Klapars, Mona Utne Larsen, John Limanto, Guiquan Liu, Yizhou Liu, Aaron Moment, Timothy Nowak, Rebecca T. Ruck, Michael Shevlin, Zhiguo Jake Song, Lushi Tan, Weidong Tong, Jacob H. Waldman, Honglin Ye, Ralph Zhao, George Zhou, Michael A. Zompa, Susan L. Zultanski
Publikováno v:
Organic Process Research & Development. 26:2728-2738
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cc17f9a7ea6c08a6dbdfe3c97ba693e
https://doi.org/10.1021/acs.oprd.2c00191
https://doi.org/10.1021/acs.oprd.2c00191
Publikováno v:
Organic Process Research & Development. 24:1665-1674
Distillation processes with several solid-state phases and dynamic multicomponent liquid-phase compositions can be challenging to understand and scale up because of complexity of the thermodynamics...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8025dfaec8f879bcb2fc90a43bc794b
https://doi.org/10.1021/acs.oprd.0c00275
https://doi.org/10.1021/acs.oprd.0c00275
Publikováno v:
Organic Syntheses. 96:137-149
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2954bb6241bdcb5a53feb363e5a43256
https://doi.org/10.15227/orgsyn.096.0137
https://doi.org/10.15227/orgsyn.096.0137
Autor:
Kevin R. Campos, Lushi Tan, Daniel A. DiRocco, Tyler A. Davis, Rebecca T. Ruck, Peter E. Maligres, Artis Klapars, John Y. L. Chung, Zhiguo Jake Song, Mona Utne Larsen, Wenyong Chen, Timothy J. Wright, Amude M. Kassim, Guiquan Liu, John Limanto, Aaron Moment, Stephen M. Dalby, Susan L. Zultanski, Louis-Charles Campeau, Ralph Calabria, Michael Shevlin, Feng Peng, Bryon Simmons, Alan M. Hyde
Publikováno v:
Chemical Science
An efficient route to the HCV antiviral agent uprifosbuvir was developed in 5 steps from readily available uridine in 50% overall yield. This concise synthesis was achieved by development of several synthetic methods: (1) complexation-driven selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619837ac9c9305f72e68520fc73a7a54
https://pubmed.ncbi.nlm.nih.gov/34276931
https://pubmed.ncbi.nlm.nih.gov/34276931
Autor:
Shane T. Grosser, Angela Spartalis, John Higgins, George Zhou, Gabriel C. Graffius, Cindy Starbuck, Busolo Wabuyele, Aaron Moment, Paul Fernandez, Lei Sun, Ganeshwar Prasad
Publikováno v:
Organic Process Research & Development. 20:653-660
The transamination-chemistry-based process for sitagliptin is a through-process, which challenges the crystallization of the active pharmaceutical ingredient (API) in a batch stream composed of multiple components. Risk-assessment-based design of exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::703d72ed10828e859636a769360d9565
https://doi.org/10.1021/acs.oprd.5b00409
https://doi.org/10.1021/acs.oprd.5b00409
Autor:
Christopher J. Welch, Eric B. Sirota, Aaron Moment, Charles Orella, Xiaoyi Gong, James Cuff, Wes Schafer, George Zhou
Publikováno v:
Organic Process Research & Development. 19:227-235
Process analytical technologies (PATs) have played an important role in process development and optimization throughout the pharmaceutical industry. Recent new PATs, including in-process video microscopy (PVM), a new generation of focused-beam reflec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1118f33632205cbe5891971ab08731d6
https://doi.org/10.1021/op5000978
https://doi.org/10.1021/op5000978
Publikováno v:
Organic Process Research & Development. 17:1320-1329
An automated crystallization platform enabled by FTIR and FBRM in combination with automation and chemometrics has provided a versatile tool for efficient crystallization process development. This system allows users to perform a “walkup” operati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acdc26b464c92d91714551e45155c04a
https://doi.org/10.1021/op400187h
https://doi.org/10.1021/op400187h
Publikováno v:
Organic Process Research & Development. 16:250-254
Concentration determination by HPLC analysis is often utilized in pharmaceutical development activities. Traditionally, manual dilutions employing volumetric glassware have to be performed to obtai...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9004f41ed923fe15b09155568fd22963
https://doi.org/10.1021/op200289r
https://doi.org/10.1021/op200289r
Autor:
Aaron Moment, Todd D. Nelson, Osama Sudah, Paul Fernandez, Michael H. Kress, Matthew R. Hickey, Stephen D. Rodgers, Mahmoud S. Kaba, Shawn P. Allwein
Publikováno v:
Organic Process Research & Development. 9:764-767
A scalable process for a pilot plant synthesis of methyl 2-bromo-6-chlorobenzoate (1) is described. The strategy employed for the synthesis hinged on the esterification of the sterically encumbered parent acid produced through an o-lithiation/carboxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80ee051f0a963a7f7c50896987a71e94
https://doi.org/10.1021/op0501444
https://doi.org/10.1021/op0501444