Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Aaron Mochizuki"'
Autor:
Robert M. Prins, Christel Herold-Mende, Linda M. Liau, Timothy F. Cloughesy, William H. Yong, Richard Everson, Anthony Wang, David Nathanson, Nicholas Bayless, Nikesh Kotecha, Alejandro Garcia, Joseph Antonios, Aaron Mochizuki, Mildred Galvez, Carmen Rapp, Saskia Roesch, Max Mastall, Janet Treger, Joey Orpilla, Shaina Sedighim, Melody Hsu, Alexander Lee, Tom B. Davidson
Supplementary Figure 3: Gene expression analysis shows increased transcription of activation and exhaustion genes in the PD-1+ population in glioma TILs and of antigen experienced genes in the PD-1+ population in glioma PBMCs (each dot represents a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dde78b81dc465a1fa300e2da7231211
https://doi.org/10.1158/1078-0432.22471280
https://doi.org/10.1158/1078-0432.22471280
Autor:
Robert M. Prins, Christel Herold-Mende, Linda M. Liau, Timothy F. Cloughesy, William H. Yong, Richard Everson, Anthony Wang, David Nathanson, Nicholas Bayless, Nikesh Kotecha, Alejandro Garcia, Joseph Antonios, Aaron Mochizuki, Mildred Galvez, Carmen Rapp, Saskia Roesch, Max Mastall, Janet Treger, Joey Orpilla, Shaina Sedighim, Melody Hsu, Alexander Lee, Tom B. Davidson
Supplementary Table 1: Panel of CyTOF markers used in our study and how each marker was classified.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a859c349ad7a82a703bad70e55bb2d1
https://doi.org/10.1158/1078-0432.22471277.v1
https://doi.org/10.1158/1078-0432.22471277.v1
Autor:
Robert M. Prins, Christel Herold-Mende, Linda M. Liau, Timothy F. Cloughesy, William H. Yong, Richard Everson, Anthony Wang, David Nathanson, Nicholas Bayless, Nikesh Kotecha, Alejandro Garcia, Joseph Antonios, Aaron Mochizuki, Mildred Galvez, Carmen Rapp, Saskia Roesch, Max Mastall, Janet Treger, Joey Orpilla, Shaina Sedighim, Melody Hsu, Alexander Lee, Tom B. Davidson
Purpose:Glioblastoma (GBM) is the most common primary malignant tumor in the central nervous system. Our recent preclinical work has suggested that PD-1/PD-L1 plays an important immunoregulatory role to limit effective antitumor T-cell responses indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b405b9d3ab6a83cb2eb931617679f7
https://doi.org/10.1158/1078-0432.c.6527837.v1
https://doi.org/10.1158/1078-0432.c.6527837.v1
Autor:
Robert M. Prins, Christel Herold-Mende, Linda M. Liau, Timothy F. Cloughesy, William H. Yong, Richard Everson, Anthony Wang, David Nathanson, Nicholas Bayless, Nikesh Kotecha, Alejandro Garcia, Joseph Antonios, Aaron Mochizuki, Mildred Galvez, Carmen Rapp, Saskia Roesch, Max Mastall, Janet Treger, Joey Orpilla, Shaina Sedighim, Melody Hsu, Alexander Lee, Tom B. Davidson
Supplementary Figure 1: T cells from GBM patient TILs show highest expression of PD-1 compared to healthy donor PBMC and GBM patient PBMCs A) A representative flow cytometry plot measuring PD-1+ expression on CD4+ and CD8+ T cells from Healthy Donor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a71858d7ce51fa1fc8f4761b150acac
https://doi.org/10.1158/1078-0432.22471286
https://doi.org/10.1158/1078-0432.22471286
Autor:
Robert M. Prins, Christel Herold-Mende, Linda M. Liau, Timothy F. Cloughesy, William H. Yong, Richard Everson, Anthony Wang, David Nathanson, Nicholas Bayless, Nikesh Kotecha, Alejandro Garcia, Joseph Antonios, Aaron Mochizuki, Mildred Galvez, Carmen Rapp, Saskia Roesch, Max Mastall, Janet Treger, Joey Orpilla, Shaina Sedighim, Melody Hsu, Alexander Lee, Tom B. Davidson
Supplementary Figure 2: Additional CyTOF data A) The percentage of the CD3+ PD-1+ cells from the TIL (green dots) and PBMCs (red dots) in each cluster (*P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f7bb31ecfe60aeeeaa6a83c799334a
https://doi.org/10.1158/1078-0432.22471283
https://doi.org/10.1158/1078-0432.22471283
Autor:
Tara Barron, Belgin Yalçın, Aaron Mochizuki, Evan Cantor, Kiarash Shamardani, Dana Tlais, Andrea Franson, Samantha Lyons, Vilina Mehta, Samin Maleki Jahan, Kathryn R. Taylor, Michael B. Keough, Haojun Xu, Minhui Su, Michael A. Quezada, Pamelyn J Woo, Paul G. Fisher, Cynthia J. Campen, Sonia Partap, Carl Koschmann, Michelle Monje
Pediatric high-grade gliomas are the leading cause of brain cancer-related death in children. High-grade gliomas include clinically and molecularly distinct subtypes that stratify by anatomical location into diffuse midline gliomas (DMG) such as diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2defa6a380a835734c28c393a50ada09
https://doi.org/10.1101/2022.11.08.515720
https://doi.org/10.1101/2022.11.08.515720
Autor:
Amy Grosnik, Richard T Graham, Natasha Pillay-Smiley, Peter de Blank, Trent Hummel, Aaron Mochizuki, Scott Raskin, Ian Windmill
Publikováno v:
Neuro-Oncology. 24:i138-i138
BACKGROUND: Most children who require cisplatin chemotherapy incur hearing loss. The basal end of the cochlea, corresponding to high frequency sound perception, is typically affected first, with progression along the basilar membrane and to lower fre
Autor:
Lu Sun, Joey Orpilla, Steven J. Bensinger, Frances Chow, Jeremy Reynoso, Robert M. Prins, David Nathanson, Linda M. Liau, Carolina Chavez, Jenny Kienzler, Timothy F. Cloughesy, Mildred Galvez, Richard Everson, Aaron Mochizuki, Willy Hugo, William H. Yong, Alexander Lee
Publikováno v:
Neuro Oncol
INTRODUCTION Neoadjuvant anti-PD1 therapy (neo-aPD1) was previously shown to significantly increase the survival of recurrent glioblastoma patients in a small randomized clinical trial. However, neo-aPD1 alone was not curative so defining the limitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb6f5f8aa3337803114379178ebf7a8
https://europepmc.org/articles/PMC7651260/
https://europepmc.org/articles/PMC7651260/
Autor:
Bita Sahaf, Sreevidya Kurra, Michelle Fujimoto, Anne Cunniffe Marcy, Crystal L. Mackall, Emily Egeler, Gerald A. Grant, Angus Toland, Kayla Landrum, John S. Tamaresis, Sneha Ramakrishna, Rebecca Richards, Paul G. Fisher, Kara L. Davis, Courtney Erickson, Steven A. Feldman, Sharon Mavroukakis, Michael Kunicki, Michelle Monje, Timothy T. Cornell, Sonia Partap, Agnes Reschke, Lindsay Rasmussen, Jasia Mahdi, Valentin Barsan, Hannes Vogel, Robbie G. Majzner, Cynthia J. Campen, Jennifer Moon, Zach Ehlinger, Christina Baggott, Kristen W. Yeom, Liora M. Schultz, Harshini Chinnasamy, Shabnum Patel, Aaron Mochizuki
Publikováno v:
Neuro-Oncology
Background We previously discovered high expression of the disialoganglioside GD2 on H3K27M+ gliomas and demonstrated preclinical efficacy of intravenous (IV) GD2-targeted chimeric antigen receptor (CAR) T-cells in preclinical models of H3K27M-mutate
Autor:
Craig Horbinski, Judith Campisi, David H. Munn, Kristen L. Lauing, Ursula Grohmann, George C. Prendergast, Karan Dixit, Aaron Mochizuki, Jeffrey Raizer, Jiahui Xu, Robert M. Prins, Derek A. Wainwright, April Bell, Changyou Zhou, Graham Pawelec, Priya Kumthekar, Jennifer D. Wu, Leonidas C. Platanias, Erik Ladomersky, Rimas V. Lukas, Joseph R. Podojil, Bin Zhang, Masha Kocherginsky, Lijie Zhai, Min Wei
Publikováno v:
Clin Cancer Res
Purpose: Wild-type isocitrate dehydrogenase–expressing glioblastoma (GBM) is the most common and aggressive primary brain tumor with a median age at diagnosis of ≥65 years. It accounts for approximately 90% of all GBMs and has a median overall su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8e858a77f71b30975d529adbc63a0d
http://hdl.handle.net/11391/1490280
http://hdl.handle.net/11391/1490280