The Telomeric Protein TRF2 Regulates Replication Origin Activity within Pericentromeric Heterochromatin

Autor: Serge Bauwens, Liudmyla Lototska, Stephane Koundrioukoff, Michelle Debatisse, Jing Ye, Eric Gilson, Aaron Mendez-Bermudez

Publikováno v: Life, Vol 11, Iss 4, p 267 (2021)

Heterochromatic regions render the replication process particularly difficult due to the high level of chromatin compaction and the presence of repeated DNA sequences. In humans, replication through pericentromeric heterochromatin requires the bindin

Externí odkaz: https://doaj.org/article/e3394010c3cd493fb73aca3211859b7c

Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia

Autor: Marie Sebert, Stéphanie Gachet, Thierry Leblanc, Alix Rousseau, Olivier Bluteau, Rathana Kim, Raouf Ben Abdelali, Flore Sicre de Fontbrune, Loïc Maillard, Carèle Fedronie, Valentine Murigneux, Léa Bellenger, Naira Naouar, Samuel Quentin, Lucie Hernandez, Nadia Vasquez, Mélanie Da Costa, Pedro H. Prata, Lise Larcher, Marie de Tersant, Matthieu Duchmann, Anna Raimbault, Franck Trimoreau, Odile Fenneteau, Wendy Cuccuini, Nathalie Gachard, Nathalie Auger, Giulia Tueur, Maud Blanluet, Claude Gazin, Michèle Souyri, Francina Langa Vives, Aaron Mendez-Bermudez, Hélène Lapillonne, Etienne Lengline, Emmanuel Raffoux, Pierre Fenaux, Lionel Adès, Edouard Forcade, Charlotte Jubert, Carine Domenech, Marion Strullu, Bénédicte Bruno, Nimrod Buchbinder, Caroline Thomas, Arnaud Petit, Guy Leverger, Gérard Michel, Marina Cavazzana, Eliane Gluckman, Yves Bertrand, Nicolas Boissel, André Baruchel, Jean-Hugues Dalle, Emmanuelle Clappier, Eric Gilson, Ludovic Deriano, Sylvie Chevret, François Sigaux, Gérard Socié, Dominique Stoppa-Lyonnet, Hugues de Thé, Christophe Antoniewski, Dominique Bluteau, Régis Peffault de Latour, Jean Soulier

Publikováno v: Cell Stem Cell
Cell Stem Cell, 2023, 30 (2), pp.153-170.e9. ⟨10.1016/j.stem.2023.01.006⟩

International audience; Fanconi anemia (FA) patients experience chromosome instability, yielding hematopoietic stem/progenitor cell (HSPC) exhaustion and predisposition to poor-prognosis myeloid leukemia. Based on a longitudinal cohort of 335 patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c04c73d99e0cccd9d3216befe9e7cea
https://hal.science/hal-04157812

Selective pericentromeric heterochromatin dismantling caused by TP53 activation during senescence

Autor: Sarantis Gagos, Olivier Croce, Florent Tessier, Yiming Lu, Joe Nassour, Liudmyla Lototska, Xiaohua Jiang, Eric Gilson, Jing Ye, Mélanie Pousse, Chrysa M Latrick, Corinne Abbadie, Aaron Mendez-Bermudez, Veronica Cherdyntseva

Cellular senescence triggers various types of heterochromatin remodeling that contribute to aging. However, the age-related mechanisms that lead to these epigenetic alterations remain elusive. Here, we asked how two key aging hallmarks, telomere shor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdffd56d6d1478d4cb1490a1e31f2287
https://doi.org/10.21203/rs.3.rs-583132/v1

Human RAP 1 specifically protects telomeres of senescent cells from DNA damage

Autor: Marie-Josèphe Giraud-Panis, Jia-Xing Yue, Liudmyla Lototska, Nicola J. Royle, Jing Li, Jing Ye, Zhou Songyang, Aaron Mendez-Bermudez, Gianni Liti, Eric Gilson

Publikováno v: EMBO Reports
EMBO Reports, EMBO Press, 2020, 21 (4), ⟨10.15252/embr.201949076⟩

Repressor/activator protein 1 (RAP1) is a highly evolutionarily conserved protein found at telomeres. Although yeast Rap1 is a key telomere capping protein preventing non‐homologous end joining (NHEJ) and consequently telomere fusions, its role at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edd1baa5852ef7a5e5d873b966d59f5
https://hal.archives-ouvertes.fr/hal-03013736

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection

Autor: Marie-Hélène Le Du, Simona Miron, Bei Pei, Hong Wang, Eric Gilson, Parminder Kaur, Arturo Londoño-Vallejo, Jing Ye, Emilie Jaune, Aaron Mendez-Bermudez, Sabrina Pisano, Marie-Josèphe Giraud-Panis, Vincent Fraisier, Julien Cherfils-Vicini, Nadir Djerbi, Eric Aeby, Delphine Benarroch-Popivker, Serge Bauwens, Kevin Foucher, Chrysa M Latrick, Liudmyla Lototska

Publikováno v: Molecular Cell
Molecular Cell, Elsevier, 2016, 61 (2), pp.274-286. ⟨10.1016/j.molcel.2015.12.009⟩
Molecular Cell, Elsevier, 2016, 61 (2), pp.274-86. ⟨10.1016/j.molcel.2015.12.009⟩
Molecular Cell, Elsevier, 2016, pp.274-86. 〈10.1016/j.molcel.2015.12.009〉
Molecular Cell, 2016, 61 (2), pp.274-86. ⟨10.1016/j.molcel.2015.12.009⟩

International audience; The shelterin proteins protect telomeres against activation of the DNA damage checkpoints and recombinational repair. We show here that a dimer of the shelterin subunit TRF2 wraps ∼ 90 bp of DNA through several lysine and ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339ad3c2caaa693ca016d61a3c1e0e13
https://hal.archives-ouvertes.fr/hal-03013754