Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Aaron Marley"'
Autor:
Xiaofang Zhong, Qiongyu Li, Benjamin J Polacco, Trupti Patil, Aaron Marley, Helene Foussard, Prachi Khare, Rasika Vartak, Jiewei Xu, Jeffrey F DiBerto, Bryan L Roth, Manon Eckhardt, Mark von Zastrow, Nevan J Krogan, Ruth Hüttenhain
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 8, Pp 952-971 (2024)
Abstract Proximity labeling (PL) via biotinylation coupled with mass spectrometry (MS) captures spatial proteomes in cells. Large-scale processing requires a workflow minimizing hands-on time and enhancing quantitative reproducibility. We introduced
Externí odkaz:
https://doaj.org/article/b1fa4dc8556644079c79cd440ac3a387
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70857 (2013)
A number of G protein-coupled receptors (GPCRs) localize to primary cilia but the functional significance of cilia to GPCR signaling remains incompletely understood. We investigated this question by focusing on the D1 dopamine receptor (D1R) and beta
Externí odkaz:
https://doaj.org/article/d88c187ad5c247feaab11aae8cf44dab
Autor:
Aaron Marley, Mark von Zastrow
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46647 (2012)
Human genetic studies are beginning to identify a large number of genes linked to neuropsychiatric disorders. It is increasingly evident that different genes contribute to risk for similar syndromes and, conversely, the same genes or even the same al
Externí odkaz:
https://doaj.org/article/e590e642bcdd4c48a793e93ada59e55d
Autor:
Aaron Marley, Mark von Zastrow
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10902 (2010)
Mutations in the DISC1 gene are strongly associated with major psychiatric syndromes such as schizophrenia. DISC1 encodes a cytoplasmic protein with many potential interaction partners, but its cellular functions remain poorly understood. We identifi
Externí odkaz:
https://doaj.org/article/2517a54cf77c48389d4c0e775ff52241
Autor:
Aaron Marley, Mark von Zastrow
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9325 (2010)
Dysbindin, a cytoplasmic protein long known to function in the biogenesis of specialized lysosome-related organelles (LROs), has been reported to reduce surface expression of D2 dopamine receptors in neurons. Dysbindin is broadly expressed, and dopam
Externí odkaz:
https://doaj.org/article/da07a99c4bd4460f8ad9cd01b215d530
Autor:
Xiaofang Zhong, Qiongyu Li, Benjamin J. Polacco, Trupti Patil, Jeffrey F. DiBerto, Rasika Vartak, Jiewei Xu, Aaron Marley, Helene Foussard, Bryan L. Roth, Manon Eckhardt, Mark Von Zastrow, Nevan J. Krogan, Ruth Hüttenhain
Proximity labeling (PL) coupled with mass spectrometry has emerged as a powerful technique to map proximal protein interactions in living cells. Large-scale sample processing for proximity proteomics necessitates a high-throughput workflow to reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5d54e5dce5c8105f7c6f2235b090509
https://doi.org/10.1101/2023.04.11.536358
https://doi.org/10.1101/2023.04.11.536358
Autor:
Mark von Zastrow, Ruqiang Liang, Chunyang Dong, Junqing Sun, Joshua D. Berke, Tommaso Patriarchi, Carolyn M.O. Davis, Brian J. Wiltgen, Aaron Marley, Ali Mohebi, Kyle R. Puhger, Lin Tian, Grace O. Mizuno
Publikováno v:
Nature methods
Genetically encoded dopamine sensors based on green fluorescent protein (GFP) enable high-resolution imaging of dopamine dynamics in behaving animals. However, these GFP-based variants cannot be readily combined with commonly used optical sensors and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015d9a0d15948b9fef4a9f78208b56c9
https://doi.org/10.1038/s41592-020-0936-3
https://doi.org/10.1038/s41592-020-0936-3
Autor:
Jounhong Ryan Cho, Axel Nimmerjahn, Tommaso Patriarchi, Ruqiang Liang, Aaron Marley, Viviana Gradinaru, Gerard Joey Broussard, Katharina Merten, John T. Williams, Lin Tian, Mark von Zastrow
Multiple aspects of neural activity, from neuronal firing to neuromodulator release and signaling, underlie brain function and ultimately shape animal behavior. The recently developed and constantly growing toolbox of genetically encoded sensors for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4ce5dffddb13a48f228c9583ba219a
https://www.zora.uzh.ch/id/eprint/178977/
https://www.zora.uzh.ch/id/eprint/178977/
Autor:
Mark von Zastrow, Wei Hong Xiong, Min Jee Jang, Mark W. Howe, Axel Nimmerjahn, Gerard Joey Broussard, Aaron Marley, Tommaso Patriarchi, Robert W. Folk, Haining Zhong, John T. Williams, Viviana Gradinaru, Ruqiang Liang, Lin Tian, Daniel A. Dombeck, Jounhong Ryan Cho, Katharina Merten
Publikováno v:
Science (New York, N.Y.), vol 360, iss 6396
Imaging dopamine release in the brain Neuromodulator release alters the function of target circuits in poorly known ways. An essential step to address this knowledge gap is to measure the dynamics of neuromodulatory signals while simultaneously manip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a75709fb9e35e644d132ac7c4027287
https://doi.org/10.1126/science.aat4422
https://doi.org/10.1126/science.aat4422
Autor:
Jeremy F. Reiter, Aaron Marley, Jacqueline E. Siljee, Sumei Zhang, Yi Wang, Adelaide Bernard, Baran A. Ersoy, Christian Vaisse, Mark von Zastrow
Publikováno v:
Nature genetics, vol 50, iss 2
Nature genetics
Nature genetics
Most monogenic cases of obesity in humans have been linked to mutations in genes encoding members of the leptin-melanocortin pathway. Specifically, mutations in MC4R, the melanocortin-4 receptor gene, account for 3-5% of all severe obesity cases in h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5b7415b669d2d3dbb5ab8aba686864
https://escholarship.org/uc/item/6185351c
https://escholarship.org/uc/item/6185351c