Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Aaron M. Savage"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Throughout the animal kingdom regenerative ability varies greatly from species to species, and even tissue to tissue within the same organism. The sheer diversity of structures and mechanisms renders a thorough comparison of molecular processes truly
Externí odkaz:
https://doaj.org/article/f092071353214a0ebfc191dd1394c0e4
Publikováno v:
Biology Open, Vol 10, Iss 10 (2021)
In vitro production of tissue-specific stem cells [e.g. haematopoietic stem cells (HSCs)] is a key goal of regenerative medicine. However, recent efforts to produce fully functional tissue-specific stem cells have fallen short. One possible cause of
Externí odkaz:
https://doaj.org/article/ade452b7c95e4f6894b57d5e56f18834
Autor:
Malika Arhatte, Gihan S. Gunaratne, Charbel El Boustany, Ivana Y. Kuo, Céline Moro, Fabrice Duprat, Magali Plaisant, Hélène Duval, Dahui Li, Nicolas Picard, Anais Couvreux, Christophe Duranton, Isabelle Rubera, Sophie Pagnotta, Sandra Lacas-Gervais, Barbara E. Ehrlich, Jonathan S. Marchant, Aaron M. Savage, Fredericus J. M. van Eeden, Robert N. Wilkinson, Sophie Demolombe, Eric Honoré, Amanda Patel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Polycystin-2 (PC2) is an ion channel commonly found mutated in autosomal dominant polycystic kidney disease. Here Arhatte et al. identify transmembrane protein 33 (TMEM33) as a regulator of PC2 function at the endoplasmic reticulum, and find that del
Externí odkaz:
https://doaj.org/article/a10e8cca0f764891af20836abbb4891c
Autor:
Aaron M. Savage, Sathishkumar Kurusamy, Yan Chen, Zhen Jiang, Karishma Chhabria, Ryan B. MacDonald, Hyejeong R. Kim, Heather L. Wilson, Fredericus J. M. van Eeden, Angel L. Armesilla, Timothy J. A. Chico, Robert N. Wilkinson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Calcium signalling downstream of VEGF is essential for VEGF-induced angiogenesis. Here Savage et al. show that Transmembrane Protein 33 (TMEM33) is required for angiogenesis and the endothelial calcium response to VEGF, revealing a function for TMEM3
Externí odkaz:
https://doaj.org/article/47f0ef6f17ce4a149e51a23dc2a30f3c
Autor:
Farah Hussein, Timothy J. A. Chico, Robert N. Wilkinson, Eric J. G. Pollitt, Jeroen Bakkers, Emily S. Noël, Christopher J Derrick, Juliana Sánchez-Posada, Fredericus J.M. van Eeden, Aaron M Savage, Federico Tessadori
Publikováno v:
Cardiovascular Research
Cardiovascular Research. Oxford University Press
Cardiovascular Research. Oxford University Press
Aims Vertebrate heart development requires the complex morphogenesis of a linear tube to form the mature organ, a process essential for correct cardiac form and function, requiring coordination of embryonic laterality, cardiac growth, and regionalize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3bd694335de19bb0aa42c7d966547b9
http://europepmc.org/articles/PMC8752364
http://europepmc.org/articles/PMC8752364
Autor:
Duygu Payzin-Dogru, Sarah E. Wilson, Steven J. Blair, Aaron M. Savage, Emil Kriukov, Victor Cat, Louis Cammarata, Burcu Erdogan, Shifa Hossain, Noah Lopez, Julia Losner, Juan Velazquez Matos, Sangwon Min, Kelly Dooling, Bobby Groves, Alan Y. Wong, Hani Singer, Petr Baranov, Isaac M. Chiu, Brian J. Haas, Jessica L. Whited
SUMMARYMany species throughout the animal kingdom naturally regenerate complex body parts following amputation. Most research in appendage regeneration has focused on identifying mechanisms that influence cell behaviors in the remaining stump tissue,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dade29f4525319474de545f4211e319
https://doi.org/10.1101/2021.12.29.474455
https://doi.org/10.1101/2021.12.29.474455
Publikováno v:
Biology Open
article-version (VoR) Version of Record
Biology Open, Vol 10, Iss 10 (2021)
article-version (VoR) Version of Record
Biology Open, Vol 10, Iss 10 (2021)
In vitro production of tissue-specific stem cells [e.g. haematopoietic stem cells (HSCs)] is a key goal of regenerative medicine. However, recent efforts to produce fully functional tissue-specific stem cells have fallen short. One possible cause of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff7e16ae43515aa08c81149e338564f
http://europepmc.org/articles/PMC8524722
http://europepmc.org/articles/PMC8524722
Publikováno v:
Developmental Dynamics. 248:410-425
BACKGROUND: Cilia are essential for morphogenesis and maintenance of many tissues. Loss-of-function of cilia in early zebrafish development causes a range of vascular defects including cerebral haemorrhage and reduced arterial vascular mural cell cov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7dcf3678c3a5bb4f032b541241e7fc3
https://doi.org/10.1002/dvdy.40
https://doi.org/10.1002/dvdy.40
Autor:
Juliana Sánchez-Posada, Farah Hussein, Aaron M Savage, Christopher J Derrick, Robert N. Wilkinson, Federico Tessadori, Eric J. G. Pollitt, Fredericus J.M. van Eeden, Timothy J. A. Chico, Jeroen Bakkers, Emily S. Noël
The mature vertebrate heart develops from a simple linear cardiac tube during early development through a series of highly asymmetric morphogenetic processes including cardiac looping and chamber ballooning. While the directionality of heart morphoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89cbd5e7b502db2bae12d62626430f6d
Autor:
Robert N. Wilkinson, Max van Lessen, Paul A. Armitage, Stefan Schulte-Merker, Jan Huisken, Stephan Daetwyler, Vishmi Silva, Karen Plant, Timothy J. A. Chico, Aaron M Savage, Ryan B. MacDonald, Karishma Chhabria, Elisabeth Kugler
Publikováno v:
EMBO Rep
We identify a novel endothelial membrane behaviour in transgenic zebrafish. Cerebral blood vessels extrude large transient spherical structures that persist for an average of 23 min before regressing into the parent vessel. We term these structures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebf65a807668ee43b0aeab09faba6d9
https://doi.org/10.15252/embr.201847047
https://doi.org/10.15252/embr.201847047