Výsledky vyhledávání - "Aaron M. Konopko"

Harnessing Redox Cross-Reactivity To Profile Distinct Cysteine Modifications

Autor: Kristin J. Labby, Ashesh Prakash, Brent R. Martin, Christopher T.M.B. Tom, Aaron M. Konopko, Jaimeen D. Majmudar, John E. Crellin

Publikováno v: Journal of the American Chemical Society. 138:1852-1859

Cysteine S-nitrosation and S-sulfination are naturally occurring post-translational modifications (PTMs) on proteins induced by physiological signals and redox stress. Here we demonstrate that sulfinic acids and nitrosothiols react to form a stable t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f137f0c4c10cc8e4010256d5bc25d6
https://doi.org/10.1021/jacs.5b06806

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Profiling Protein S-Sulfination with Maleimide-Linked Probes

Autor: Aaron M. Konopko, Brent R. Martin, Jaimeen D. Majmudar, Nicholas B. Borotto, Yu Hsuan Kuo, Sarah E. Haynes

Publikováno v: Chembiochem : a European journal of chemical biology. 18(20)

Cysteine residues are susceptible to oxidation to form S-sulfinyl (R-SO2 H) and S-sulfonyl (R-SO3 H) post-translational modifications. Here we present a simple bioconjugation strategy to label S-sulfinated proteins by using reporter-linked maleimides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847ef4f8d585ceb03d83149ebe9d0b04
https://pubmed.ncbi.nlm.nih.gov/28809078

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Chlorophyllin Derivatives as Photosensitizers: Synthesis and Photodynamic Properties

Autor: Mauricio S. Baptista, Adjaci F. Uchoa, Aaron M. Konopko

Publikováno v: Journal of the Brazilian Chemical Society v.26 n.12 2015
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 26, Issue: 12, Pages: 2615-2622, Published: DEC 2015

Two new photosensitizers (PSs) derived from copper-chlorophyllin were designed to have excitation wavelengths appropriate for the use in photodynamic therapy (PDT) and to have amphiphilic character with positive charge, which favors binding to cell m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488d16b631e8e5d6a5164f2009012d19
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015001202615

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