Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Aaron M. Keeler"'
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104608- (2022)
Externí odkaz:
https://doaj.org/article/73337981ad9d401b9ca76a975627f563
Autor:
Edward Kalkreuter, Kyle S. Bingham, Aaron M. Keeler, Andrew N. Lowell, Jennifer J. Schmidt, David H. Sherman, Gavin J. Williams
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Engineering efforts have focused on acyltransferase (AT) domains of modular polyketide synthases (PKSs) to site-selectively modify the resulting polyketides, but critical AT residues involved in substrate selection have not been fully elucidated. Her
Externí odkaz:
https://doaj.org/article/8ac2f471c63242d2830d7699ac214224
Publikováno v:
ACS Chemical Biology. 18:785-793
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e8914234bd2d10999e58a4dc8080b49
https://doi.org/10.1021/acschembio.2c00783
https://doi.org/10.1021/acschembio.2c00783
Autor:
Aaron M. Keeler, Porter E. Petruzziello, Elizabeth G. Boger, Hannah K. D’Ambrosio, Emily R. Derbyshire
Polyketide synthases (PKSs) are megaenzymes that form chemically diverse polyketides and are found within the genomes of nearly all classes of life. We recently discovered the type I PKS from the apicomplexan parasiteToxoplasma gondii, TgPKS2, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98353adc521507e6c0a254461b98c15a
https://doi.org/10.1101/2023.05.23.541938
https://doi.org/10.1101/2023.05.23.541938
Publikováno v:
iScience. 25(6)
Type I polyketide synthases (PKSs) are multidomain, multimodule enzymes capable of producing complex polyketide metabolites. These modules contain an acyltransferase (AT) domain, which selects acyl-CoA substrates to be incorporated into the metabolit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::92733f79f094cd2c43bd512388985604
https://pubmed.ncbi.nlm.nih.gov/35772031
https://pubmed.ncbi.nlm.nih.gov/35772031
Autor:
Aaron M Keeler, Gavin J. Williams, Kyle S Bingham, David H. Sherman, Jennifer J. Schmidt, Edward Kalkreuter, Andrew N. Lowell
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Polyketides, one of the largest classes of natural products, are often clinically relevant. The ability to engineer polyketide biosynthesis to produce analogs is critically important. Acyltransferases (ATs) of modular polyketide synthases (PKSs) cata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88e9c6a4d96ed4ab4f7466846186634
https://hdl.handle.net/10919/104639
https://hdl.handle.net/10919/104639
Autor:
Gavin J. Williams, Edward Kalkreuter, Aaron M Keeler, Anuran K Gayen, Kyle S Bingham, Alexandra A Malico
Publikováno v:
ACS Synth Biol
The scaffolds of polyketides are constructed via assembly of extender units based on malonyl-CoA and its derivatives that are substituted at the C2-position with diverse chemical functionality. Subsequently, a transcription factor-based biosensor for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc366057958c7a90b9c1d747ab3c4c4e
https://pubmed.ncbi.nlm.nih.gov/31134799
https://pubmed.ncbi.nlm.nih.gov/31134799
Autor:
Ghada Rabah, Ericka Ford, Yaewon Park, Nathalia Ortiz, Drake Johnson, Terrence G. Gardner, Shuang Liu, Aaron M Keeler
Publikováno v:
Journal of Engineered Fibers and Fabrics. 15:155892501989895
Manganese-oxidizing fungi support bioremediation through the conversion of manganese ions into manganese oxide deposits that in turn adsorb manganese and other heavy metal ions from the environment. Manganese-oxidizing fungi were immobilized onto nan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e79a50de30adeaca2e38633cbe5ee717
https://doi.org/10.1177/1558925019898954
https://doi.org/10.1177/1558925019898954