Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Aaron M. Gruver"'
Autor:
Aaron M. Gruver, Haiyan Lu, Xiaoxian Zhao, Angie D. Fulford, Michael D. Soper, Darryl Ballard, Jeffrey C. Hanson, Andrew E. Schade, Eric D. Hsi, Klaus Gottlieb, Kelly M. Credille
Publikováno v:
Diagnostic Pathology, Vol 18, Iss 1, Pp 1-12 (2023)
Abstract Background Histologic evaluation of the mucosal changes associated with celiac disease is important for establishing an accurate diagnosis and monitoring the impact of investigational therapies. While the Marsh-Oberhuber classification has b
Externí odkaz:
https://doaj.org/article/77800cfdc1234688b422c739cee2d36c
Autor:
Michael Crager, Sameera R. Wijayawardana, Aaron M. Gruver, Andrea Blacklock, Christy Russell, Frederick L. Baehner, Francisco Sapunar
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-7 (2022)
Abstract Background The United States Food and Drug Administration recently approved a Ki-67 immunohistochemistry (IHC) assay to identify patients with early breast cancer at high disease recurrence risk. The Oncotype Dx Breast Recurrence Score® ass
Externí odkaz:
https://doaj.org/article/29436609f41c471aa39faa948b2588b3
Autor:
Tyler MacNeil, Ioannis A. Vathiotis, Saba Shafi, Thazin Nwe Aung, Jon Zugazagoitia, Aaron M. Gruver, Kyla Driscoll, David L. Rimm
Publikováno v:
Cancers, Vol 13, Iss 21, p 5501 (2021)
Pancreatic cancer is marked by a desmoplastic tumor microenvironment and low tumor immunogenicity, making it difficult for immunotherapy drugs to improve outcomes for patients. Tumor-infiltrating lymphocytes (TILs) and cancer-associated fibroblasts (
Externí odkaz:
https://doaj.org/article/deb20120a8434c9b8d33d3559534c68e
Autor:
Ioannis A. Vathiotis, Tyler MacNeil, Jon Zugazagoitia, Konstantinos N. Syrigos, Thazin Nwe Aung, Aaron M. Gruver, Peter Vaillancourt, Ina Hughes, Steve Hinton, Kyla Driscoll, David L. Rimm
Publikováno v:
Cancers, Vol 13, Iss 5, p 1024 (2021)
CD200/CD200R is an immune checkpoint with broad expression patterns and a potential target for immune therapy. In this study, we assess both CD200 and CD200R expression in solid tumors, with a focus on lung cancer, and evaluate their association with
Externí odkaz:
https://doaj.org/article/8bbd60c760eb411ea83577e9bf718876
Autor:
Aaron M Gruver, Salisha Hill, Daniel C. Liebler, Jochen Schmitz, Juraj Bodo, Keith Lai, Robert J. Benschop, Bradley L. Ackermann, David C Gemperline, Ryan D. Morrison, Eric D. Hsi, Matt D Westfall
Publikováno v:
Journal of Clinical Pathology. 75:636-642
Aims and methodsAccurate protein measurements using formalin-fixed biopsies are needed to improve disease characterisation. This feasibility study used targeted and global mass spectrometry (MS) to interrogate a spectrum of disease severities using 1
Autor:
Bradley L. Ackermann, Ryan D. Morrison, Salisha Hill, Matthew D. Westfall, Brent D. Butts, Michael D. Soper, Jeff A. Fill, Andrew E. Schade, Daniel C. Liebler, Aaron M. Gruver
Publikováno v:
Laboratory Investigation. 103:100052
Autor:
Miglena Komforti, Erinn Downs-Kelly, Francisco Sapunar, Sameera R. Wijayawardana, Aaron M. Gruver, Sunil S. Badve
Publikováno v:
Applied immunohistochemistrymolecular morphology : AIMM. 30(8)
The objective of this study was to measure concordance of results obtained from the US Food and Drug Administration-approved Ki-67 immunohistochemistry MIB-1 pharmDx assay performed on the Dako Omnis automated staining instrument (Omnis) versus resul
Autor:
Aaron M Gruver, Jeff A. Fill, Alexander Haragan, Bradley L. Ackermann, Robbert J.C. Slebos, Andrew E. Schade, Ryan D. Morrison, Michael D Soper, Daniel C. Liebler, John R. Gosney, Dimple M Das
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology
Laboratory Investigation
Laboratory Investigation
Immunohistochemistry (IHC) using formalin-fixed, paraffin embedded (FFPE) tissue is limited by epitope masking, posttranslational modification and immunoreactivity loss that occurs in stored tissue by poorly characterized mechanisms. Conformational e
Autor:
Volker Wacheck, Johan Wallin, Nicolas Girard, Matteo Brighenti, Christian Schumann, Adolfo Favaretto, Chun-Ming Tsai, Giorgio V. Scagliotti, M Kimmich, Te Chun Hsia, Eun Kyung Cho, Kambiz Mansouri, Sameera R. Wijayawardana, Aaron M Gruver, Heidrun Grosch, Denis Moro-Sibilot, Jens Kollmeier, Xuejing Aimee Wang, Gee-Chen Chang
Publikováno v:
Transl Lung Cancer Res
Introduction The hepatocyte growth factor receptor mesenchymal-epithelial transition (MET) is reported to be a negative prognostic marker in EGFR-mutant NSCLC and involved in resistance to EGFR inhibitors. Emibetuzumab, a humanized immunoglobulin G4
Autor:
Wei Zeng, Leendert H. J. Looijenga, Stefan M. Willems, Ling Liu, Robert J. Baatenburg de Jong, Senada Koljenović, Maria J. De Herdt, Daan Nieboer, Aaron M Gruver, Rob Noorlag, Jose A. Hardillo, Berdine van der Steen
Publikováno v:
Modern Pathology, 33(6), 1015-1032. Nature Publishing Group
Ectodomain shedding unleashes the aggressive nature of the MET oncogene product. Using specific C- and N-terminal MET antibodies (D1C2 and A2H2-3), MET protein status (i.e., no MET, decoy MET, transmembranous C-terminal MET with or without the ectodo