Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Aaron M. Fullerton"'
Publikováno v:
Toxicology and Applied Pharmacology. 266:317-327
Inflammation plays a major role in immune-mediated liver injury, and exposure to environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been reported to alter the inflammatory response as well as affect immune cell activity.
Publikováno v:
Toxicological Sciences. 120:507-518
Severe halothane (HAL)-induced hepatotoxicity occurs in one in 6000-30,000 patients by an unknown mechanism. Female sex is a risk factor in humans and rodents. We tested the hypothesis that a sex difference in natural killer (NK) cell activity contri
Autor:
Lance R. Pohl, Mohammed Bourdi, Warren J. Leonard, Lynette S. Chea, Julia D. Berkson, Midhun C. Korrapati, Kenrick Semple, Albert P. Li, Rosanne Spolski, William R. Proctor, Jeffrey C. Morrison, Qian Yang, Aaron M. Fullerton, Mala Chakraborty, Pauline M. Ryan, Yrina Rochman, Erin E. West
Publikováno v:
Hepatology (Baltimore, Md.). 60(5)
Liver eosinophilia has been associated with incidences of drug-induced liver injury (DILI) for more than 50 years, although its role in this disease has remained largely unknown. In this regard, it was recently shown that eosinophils played a pathoge
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 137(1)
Idiosyncratic drug-induced liver injury (IDILI) continues to be a significant human health problem. IDILI is characterized as occurring in a minority of individuals exposed to a drug, yet it accounts for as much as 17% of all cases of acute liver fai
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 136(1)
For many liver diseases, including viral and autoimmune hepatitis, immune cells play an important role in the development and progression of liver injury. Concanavalin A (Con A) administration to rodents has been used as a model of immune-mediated li
Publikováno v:
Toxicology and applied pharmacology. 236(3)
The use of the fluoroquinolone antibiotic trovafloxacin (TVX) was severely restricted in 1999 due to its association with idiosyncratic hepatotoxicity. Previously, we reported that a nontoxic dose of TVX interacts with a nontoxic dose of lipopolysacc
Publikováno v:
The FASEB Journal. 21
Autor:
Jason Alkirwi, Heather Hertema, Jessica Odette, Kaillathe Padmanabhan, Sundari Chodavarapu, D’Juan Hartsfield, Joe D. Beckmann, Tien Huynh, Aaron M. Fullerton, Caleb Woods, Rachel Miller
Publikováno v:
Archives of biochemistry and biophysics. 457(2)
Phenol sulfotransferases (SULTs), which normally bind 3'-phosphoadenosine-5'-phosphosulfate as the donor substrate, are inhibited by CoA and its thioesters. Here, we report that inhibition of bovine SULT1A1 by CoA is time-dependent at neutral pH unde
Autor:
Beggs, Kevin M., Fullerton, Aaron M., Miyakawa, Kazuhisa, Ganey, Patricia E., Roth, Robert A.
Publikováno v:
Toxicological Sciences; Jan2014, Vol. 137 Issue 1, p91-101, 11p
Publikováno v:
Toxicological Sciences; Nov2013, Vol. 136 Issue 1, p72-85, 14p