Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Aaron M Swomley"'
Autor:
Chun-Hau Chen, Wenzong Li, Rukhsana Sultana, Mi-Hyeon You, Asami Kondo, Koorosh Shahpasand, Byeong Mo Kim, Man-Li Luo, Morris Nechama, Yu-Min Lin, Yandan Yao, Tae Ho Lee, Xiao Zhen Zhou, Aaron M. Swomley, D. Allan Butterfield, Yan Zhang, Kun Ping Lu
Publikováno v:
Neurobiology of Disease, Vol 76, Iss , Pp 13-23 (2015)
The unique proline isomerase Pin1 is pivotal for protecting against age-dependent neurodegeneration in Alzheimer's disease (AD), with its inhibition providing a molecular link between tangle and plaque pathologies. Pin1 is oxidatively modified in hum
Externí odkaz:
https://doaj.org/article/d411781e221e406fa456c9193b66ddf6
Autor:
Molly E. Droege, Eric W. Mueller, Daniel R Mosher, Aaron M Swomley, Abigail G Rhoades, Christopher A. Droege, Neil Ernst
Publikováno v:
American journal of therapeutics.
BACKGROUND Altered drug and nutrient absorption presents a unique challenge in critically ill patients. Performing an acetaminophen absorption test (AAT) has been used as a marker for gastric motility and upper small bowel absorption; thus, it may pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213cafd6bbfa17e0f8bd119b7aca18e6
https://pubmed.ncbi.nlm.nih.gov/34387562
https://pubmed.ncbi.nlm.nih.gov/34387562
Publikováno v:
Free Radic Biol Med
Parkinson disease (PD) is the second most common neurodegenerative disease associated with aging. Dopaminergic neuronal degeneration and α-synuclein aggregation are commonly found in PD brain. Oxidative damage and inflammation often are considered a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a73348e18882b290f8737be0466a0d
https://doi.org/10.1016/j.freeradbiomed.2019.08.008
https://doi.org/10.1016/j.freeradbiomed.2019.08.008
Autor:
Aaron M. Swomley, Judy C. Triplett, Jian Cai, Jeriel T. R. Keeney, Govind Warrier, Julie A. Mattison, Kevin J. Pearson, D. Allan Butterfield, Rafael de Cabo, Jon B. Klein
Publikováno v:
The Journal of Nutritional Biochemistry. 39:169-179
A diet consisting of a high intake of saturated fat and refined sugars is characteristic of a Western-diet and has been shown to have a substantial negative effect on human health. Expression proteomics were used to investigate changes to the parieta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ac2afe4d4603ad73d840d7ed305bc0
https://doi.org/10.1016/j.jnutbio.2016.10.006
https://doi.org/10.1016/j.jnutbio.2016.10.006
Publikováno v:
Journal of Alzheimer's Disease. 49:45-62
Alzheimer’s disease (AD), the most common age-related neurodegenerative disorder, is clinically characterized by progressive neuronal loss resulting in loss of memory and dementia. AD is histopathologically characterized by the extensive distributi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2895e171163070a0282a14284a5abc94
https://doi.org/10.3233/jad-150417
https://doi.org/10.3233/jad-150417
Autor:
Judy C. Triplett, Karl A. Rodriguez, Jon B. Klein, Aaron M. Swomley, Miranda E. Orr, Kelly M. Grimes, Rochelle Buffenstein, D. Allan Butterfield, Jian Cai, Kaitilyn N. Lewis, Marzia Perluigi, Jessime Kirk, Antonella Tramutola
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1852(10):2213-2224
The naked mole-rat (NMR) is the longest-lived rodent and possesses several exceptional traits: marked cancer resistance, negligible senescence, prolonged genomic integrity, pronounced proteostasis, and a sustained health span. The underlying molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55dc96d626a5d6a159a2fff1f1c0e2eb
Metabolic clues to salubrious longevity in the brain of the longest-lived rodent: the naked mole-rat
Autor:
Aaron M. Swomley, Jian Cai, Miranda E. Orr, Jessime Kirk, Judy C. Triplett, Jon B. Klein, Rochelle Buffenstein, Katilyn Lewis, D. Allan Butterfield, Karl A. Rodriguez
Publikováno v:
Journal of Neurochemistry. 134:538-550
Naked mole-rats (NMRs) are the oldest-living rodent species. Living underground in a thermally stable ecological niche, NMRs have evolved certain exceptional traits, resulting in sustained health spans, negligible cognitive decline, and a pronounced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4d4e9d7d857227ce846db200941d7b
https://doi.org/10.1111/jnc.13149
https://doi.org/10.1111/jnc.13149
Publikováno v:
The Biochemical journal, vol 463, iss 2
Accumulation of oxidative damage is a common feature of neurodegeneration that, together with mitochondrial dysfunction, point to the fact that reactive oxygen species are major contributors to loss of neuronal homoeostasis and cell death. Among seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba22abbeb3157e39b6235c33300f5ba
https://doi.org/10.1042/bj20140772
https://doi.org/10.1042/bj20140772
Publikováno v:
Ageing Research Reviews. 13:75-89
It is well established that the risk to develop neurodegenerative disorders increases with chronological aging. Accumulating studies contributed to characterize the age-dependent changes either at gene and protein expression level which, taken togeth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8703bfa6b4fa905d627a6903b41bdd9d
https://doi.org/10.1016/j.arr.2013.12.005
https://doi.org/10.1016/j.arr.2013.12.005
Publikováno v:
Antioxidants & Redox Signaling. 19:823-835
Significance: Alzheimer disease (AD) is an age-related neurodegenerative disease. AD is characterized by progressive cognitive impairment. One of the main histopathological hallmarks of AD brain is the presence of senile plaques (SPs) and another is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cacb011c6b21ebdb3b4a17b0006d307e
https://doi.org/10.1089/ars.2012.5027
https://doi.org/10.1089/ars.2012.5027