Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Aaron M Fleming"'
Publikováno v:
ACS Bio & Med Chem Au, Vol 1, Iss 1, Pp 44-56 (2021)
Externí odkaz:
https://doaj.org/article/4fb42859cc844d52a0635916be500285
Publikováno v:
ACS Central Science, Vol 7, Iss 10, Pp 1707-1717 (2021)
Externí odkaz:
https://doaj.org/article/0e3bf8f6f92745a8aa73db451bc668eb
Publikováno v:
ACS Central Science, Vol 5, Iss 2, Pp 218-228 (2019)
Externí odkaz:
https://doaj.org/article/b03fb80bb6b240ad94e9db553d1f7ed0
Publikováno v:
Journal of physical organic chemistry. 35(11)
Fluorescent dyes are routinely used to visualize DNA or RNA in various experiments, and some dyes also act as photosensitizers capable of catalyzing oxidation reactions. The present studies explored whether the common labeling dyes fluorescein, rhoda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81773a8883263a8e74ac68fac510a132
https://pubmed.ncbi.nlm.nih.gov/36388261
https://pubmed.ncbi.nlm.nih.gov/36388261
Autor:
Aaron M Fleming, Cynthia J Burrows
Publikováno v:
Nucleic Acids Research. 51:1914-1926
Direct RNA sequencing with a commercial nanopore platform was used to sequence RNA containing uridine (U), pseudouridine (Ψ), or N1-methylpseudouridine (m1Ψ) generated by in vitro transcription (IVT). The base calling data as well as the ionic curr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8799363beea774abe81819c7955468
https://doi.org/10.1093/nar/gkad044
https://doi.org/10.1093/nar/gkad044
Publikováno v:
RSC Chemical Biology. 4:261-270
APE1 complexed with an abasic site in G-quadruplex (G4) topologies displays differences in binding constants, enzyme cleavage yields, and gene regulation. APE1 tightly binds parallel G4s to regulate transcription that is not found with hybrid G4s.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::788331068e9bca26e8bb5083ae9a35fd
https://doi.org/10.1039/d2cb00233g
https://doi.org/10.1039/d2cb00233g
Autor:
Aaron M. Fleming, Renee Tran, Carla A. Omaga, Shereen A. Howpay Manage, Cynthia J. Burrows, John C. Conboy
Publikováno v:
Analytical Chemistry. 94:15027-15032
The binding interaction between the DNA repair enzyme apurinic/apyrimidinic endonuclease-1 (APE1) with promoter G-quadruplex (G4) folds bearing an abasic site (AP) can serve as a gene regulatory switch during oxidative stress. Prior fluorescence-base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e521bedc8656b3761c5745ce9720cf
https://doi.org/10.1021/acs.analchem.2c02951
https://doi.org/10.1021/acs.analchem.2c02951
Publikováno v:
The Journal of Organic Chemistry. 87:11865-11870
Exposure of DNA to oxidants results in modification of the electron-rich guanine heterocycle including formation of the mutagenic 5-carboxamido-5-formamido-2-iminohydantoin (2Ih) lesion. Previously thought to exist solely as a pair of diastereomers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0bb4811158ab38cf2c8ed49df5a55da
https://doi.org/10.1021/acs.joc.2c01371
https://doi.org/10.1021/acs.joc.2c01371
Publikováno v:
Organic Letters. 24:6182-6185
In RNA, pseudouridine (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2abb81fad369f339bbb8a2c34bf8232e
https://doi.org/10.1021/acs.orglett.2c02427
https://doi.org/10.1021/acs.orglett.2c02427
Autor:
Rodrigo Galindo-Murillo, Lauren Winkler, Jingwei Ma, Fatjon Hanelli, Aaron M. Fleming, Cynthia J. Burrows, Thomas E. Cheatham
Publikováno v:
Biochemistry. 61:265-275
The G-quadruplex is a noncanonical fold of DNA commonly found at telomeres and within gene promoter regions of the genome. These guanine-rich sequences are highly susceptible to damages such as base oxidation and depurination, leading to abasic sites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0e90bf02edea1a48013461caff87f6
https://doi.org/10.1021/acs.biochem.1c00598
https://doi.org/10.1021/acs.biochem.1c00598