Výsledky vyhledávání - "Aaron M Domina"

Akademický článek

Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancer.

Autor: Shanna K Nifoussi, Julie A Vrana, Aaron M Domina, Alfredo De Biasio, Jingang Gui, Mark A Gregory, Stephen R Hann, Ruth W Craig

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47060 (2012)

The antiapoptotic Bcl-2 family member Mcl-1 is a PEST protein (containing sequences enriched in proline, glutamic acid, serine, and threonine) and is subject to rapid degradation via multiple pathways. Impaired degradation leading to the maintenance

Externí odkaz: https://doaj.org/article/44c4beca0b6b4370a1fa1cb8e3dadb1b

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A Novel NOD2-associated Mutation and Variant Blau Syndrome: Phenotype and Molecular Analysis

Autor: Nazanin Ebrahimiadib, Aaron M. Domina, C. Stephen Foster, Roger Ewer, Charlie P. Bocian, Ethan R. Stiles, Khawla Abu Samra

Publikováno v: Ocular Immunology and Inflammation. 26:57-64

Purpose: To describe the clinical and molecular implications of a novel mutation in the NOD2/CARD15 gene on a family and its seven affected members.Methods: We reviewed the clinical presentations of family members who came to our center for refractor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d28ba7e75a7c3d1f986088213324b9
https://doi.org/10.1080/09273948.2016.1185529

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Evaluation of curcumin, a natural product in turmeric, on Burkitt lymphoma and acute myeloid leukemia cancer stem cell markers

Autor: Aaron M. Domina, Gi Lim, Tao Zhang, Yanyan Li, Teralyn Chang

Publikováno v: Future oncology (London, England). 14(23)

Aim: Curcumin, a bioactive compound from turmeric, eliminates cancer stem cells (CSCs) in some cancers. This study evaluates the effects of curcumin on CSC markers in Burkitt lymphoma and acute myeloid leukemia cells. Methods: Cells were treated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a84dfd066ed183d6b2c4d566e426b4b
https://pubmed.ncbi.nlm.nih.gov/30139269

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Alphavirus production is inhibited in neurofibromin 1-deficient cells through activated RAS signalling

Autor: Aaron M. Domina, Olga A. Kolokoltsova, Andrey A. Kolokoltsov, Scott C. Weaver, Stanley J. Watowich, Robert A. Davey

Publikováno v: Virology. 377:133-142

Virus–host interactions essential for alphavirus pathogenesis are poorly understood. To address this shortcoming, we coupled retrovirus insertional mutagenesis and a cell survival selection strategy to generate clonal cell lines broadly resistant t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad12a86b283ad32f1e35a46f0cd8776
https://doi.org/10.1016/j.virol.2008.03.025

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N-terminal Truncation of Antiapoptotic MCL1, but Not G2/M-induced Phosphorylation, Is Associated with Stabilization and Abundant Expression in Tumor Cells

Autor: Ruth W. Craig, Liping Qian, Steven J. Weintraub, Aaron M. Domina, Julie A. Vrana, Karen Braley, John M. Neveu, Christine K. Bieszczad, Ping Zhou, William S. Lane, Alfredo De Biasio

Publikováno v: Journal of Biological Chemistry. 282:23919-23936

The antiapoptotic BCL2 family member MCL1 is normally up- and down-modulated in response to environmental signals and conditions, but is constitutively expressed in cancer where it promotes cell survival and drug resistance. A post-translational modi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ccdf8f0dac9bcf3b9bff78541ddafc
https://doi.org/10.1074/jbc.m700938200

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Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancer

Autor: Stephen R. Hann, Jingang Gui, Aaron M. Domina, Julie A. Vrana, Mark A. Gregory, Ruth W. Craig, Shanna K. Nifoussi, Alfredo De Biasio

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47060 (2012)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99894756be61468ccd88ce7c835bc7b2
http://europepmc.org/articles/PMC3467206?pdf=render

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MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol

Autor: Ruth W. Craig, Aaron M. Domina, Julie A. Vrana, Mark A. Gregory, Stephen R. Hann

Publikováno v: Oncogene. 23(31)

BCL2 family members are subject to regulation at multiple levels, providing checks on their ability to contribute to tumorigenesis. However, findings on post-translational BCL2 phosphorylation in different systems have been difficult to integrate. An

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9a4027502428ed8a6c6d7686c6bf6b
https://pubmed.ncbi.nlm.nih.gov/15241487

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Myeloid cell leukemia 1 is phosphorylated through two distinct pathways, one associated with extracellular signal-regulated kinase activation and the other with G2/M accumulation or protein phosphatase 1/2A inhibition

Autor: Aaron M. Domina, Jessica H. Smith, Ruth W. Craig

Publikováno v: The Journal of biological chemistry. 275(28)

Protein kinase C activators and microtubule-damaging drugs stimulate BCL2 phosphorylation, which has been associated with either enhancement or inhibition of cell viability. In a Burkitt lymphoma cell line, both types of agents likewise stimulated ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1469f39abdb9f1718a4368bc0e50d0
https://pubmed.ncbi.nlm.nih.gov/10777489

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