Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Aaron Lock"'
Autor:
Darren C. Holland, Dale W. Prebble, Mark J. Calcott, Wayne A. Schroder, Francesca Ferretti, Aaron Lock, Vicky M. Avery, Milton J. Kiefel, Anthony R. Carroll
Publikováno v:
Molecules, Vol 29, Iss 15, p 3648 (2024)
Marine natural products (MNPs) continue to be tested primarily in cellular toxicity assays, both mammalian and microbial, despite most being inactive at concentrations relevant to drug discovery. These MNPs become missed opportunities and represent a
Externí odkaz:
https://doaj.org/article/f89cc53b0fe941b8a953a64e5fcc6f23
Autor:
Kelsey S. Ramage, Aaron Lock, Jonathan M. White, Merrick G. Ekins, Milton J. Kiefel, Vicky M. Avery, Rohan A. Davis
Publikováno v:
Marine Drugs, Vol 22, Iss 1, p 33 (2024)
The known oxygenated polyhalogenated diphenyl ether, 2-(2′,4′-dibromophenoxy)-3,5-dibromophenol (1), with previously reported activity in multiple cytotoxicity assays was isolated from the sponge Lamellodysidea sp. and proved to be an amenable sc
Externí odkaz:
https://doaj.org/article/b542577dbc8c4ff787036ada173fd849
Publikováno v:
Drug Discovery Today: Disease Models. 21:11-16
Breast cancer is a complex group of diseases and is one of the most common cancers diagnosed worldwide. Many studies have shown that tumour progression and drug responses vary due to tumour heterogeneity caused by genetic mutations and aberrant prote
Autor:
Graeme Irvine Stevenson, Juliette E Neve, Vicky M. Avery, Sarah Yong, Aaron Lock, Gregory Allen Fechner
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(14)
The authors would like to apologise and point out that the following corrections are required to Fig. 1, Fig. 2, Scheme 1 and Scheme 2. Hydrogens are missing from the structure of the Biotin ring system
Publikováno v:
SAE Technical Paper Series.
Autor:
Aaron Lock, Juliette E Neve, Gregory Allen Fechner, Sarah Yong, Graeme Irvine Stevenson, Vicky M. Avery
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(20)
Inhibition of isoprenylcysteine Carboxylmethyltransferase (ICMT) is of particular interest as a potential target for the development of cancer chemotherapeutic agents. Screening for inhibitors of ICMT utilises a scintillation proximity assay (SPA) in
Publikováno v:
SAE Technical Paper Series.