Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Aaron L. Statham"'
Autor:
Mark Pinese, Paul Lacaze, Emma M. Rath, Andrew Stone, Marie-Jo Brion, Adam Ameur, Sini Nagpal, Clare Puttick, Shane Husson, Dmitry Degrave, Tina Navin Cristina, Vivian F. S. Kahl, Aaron L. Statham, Robyn L. Woods, John J. McNeil, Moeen Riaz, Margo Barr, Mark R. Nelson, Christopher M. Reid, Anne M. Murray, Raj C. Shah, Rory Wolfe, Joshua R. Atkins, Chantel Fitzsimmons, Heath M. Cairns, Melissa J. Green, Vaughan J. Carr, Mark J. Cowley, Hilda A. Pickett, Paul A. James, Joseph E. Powell, Warren Kaplan, Greg Gibson, Ulf Gyllensten, Murray J. Cairns, Martin McNamara, Marcel E. Dinger, David M. Thomas
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Healthspan and healthy aging are areas of research with potential socioeconomic impact. Here, the authors present the Medical Genome Reference Bank (MGRB) which consist of over 4,000 individuals aged 70 years and older without a history of the major
Externí odkaz:
https://doaj.org/article/606fe68d7d054718aee8c708231ad376
Autor:
Amanda Khoury, Joanna Achinger-Kawecka, Saul A. Bert, Grady C. Smith, Hugh J. French, Phuc-Loi Luu, Timothy J. Peters, Qian Du, Aled J. Parry, Fatima Valdes-Mora, Phillippa C. Taberlay, Clare Stirzaker, Aaron L. Statham, Susan J. Clark
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The architectural protein CTCF is a mediator of chromatin conformation, but how CTCF binding to DNA is regulated remains poorly understood. Here the authors find that there is a shared subset of CTCF-bound sites resistant to protein depletion in diff
Externí odkaz:
https://doaj.org/article/8b6198ec146c403090e434c6de6028fa
Autor:
Fátima Valdés-Mora, Cathryn M. Gould, Yolanda Colino-Sanguino, Wenjia Qu, Jenny Z. Song, Kylie M. Taylor, Fabian A. Buske, Aaron L. Statham, Shalima S. Nair, Nicola J. Armstrong, James G. Kench, Kenneth M. L. Lee, Lisa G. Horvath, Minru Qiu, Alexei Ilinykh, Nicole S. Yeo-Teh, David Gallego-Ortega, Clare Stirzaker, Susan J. Clark
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Acetylation of the histone variant H2A.Z at gene promoters is associated with oncogene activation; however, it is unclear if such modification has a role in regulating the function of enhancers. Here the authors show that acetylated H2A.Z is redistri
Externí odkaz:
https://doaj.org/article/d2ff8d2d6d19424694b455f94d09d58c
Publikováno v:
Genes, Vol 6, Iss 4, Pp 1140-1163 (2015)
Combined Bisulfite Restriction Analysis (COBRA) quantifies DNA methylation at a specific locus. It does so via digestion of PCR amplicons produced from bisulfite-treated DNA, using a restriction enzyme that contains a cytosine within its recognition
Externí odkaz:
https://doaj.org/article/150b488165b34a9b97ad7ac30d89be81
Publikováno v:
Genomics Data, Vol 3, Iss C, Pp 94-96 (2015)
DNA methylation and nucleosome positioning are two key mechanisms that contribute to the epigenetic control of gene expression. During carcinogenesis, the expression of many genes is altered alongside extensive changes in the epigenome, with represse
Externí odkaz:
https://doaj.org/article/287f87645bde4dab872ced9c5558446b
Autor:
Susan J. Clark, Robert L. Sutherland, Miguel A. Peinado, Regina Mayor, Anne-Maree Haynes, Ruth Pe Benito, Susan M. Henshall, James G. Kench, Toby Hulf, Marcel W. Coolen, Bruce Tabor, Lisa G. Horvath, Kate I. Patterson, Aaron L. Statham, Jenny Z. Song, Wenjia Qu, Clare Stirzaker, James Devaney
Supplementary Figure 3 from Epigenetic Deregulation Across Chromosome 2q14.2 Differentiates Normal from Prostate Cancer and Provides a Regional Panel of Novel DNA Methylation Cancer Biomarkers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8446b14eac8fcbc87483466d17c8921d
https://doi.org/10.1158/1055-9965.22435222.v1
https://doi.org/10.1158/1055-9965.22435222.v1
Autor:
Susan J. Clark, Robert L. Sutherland, Miguel A. Peinado, Regina Mayor, Anne-Maree Haynes, Ruth Pe Benito, Susan M. Henshall, James G. Kench, Toby Hulf, Marcel W. Coolen, Bruce Tabor, Lisa G. Horvath, Kate I. Patterson, Aaron L. Statham, Jenny Z. Song, Wenjia Qu, Clare Stirzaker, James Devaney
Supplementary Table and Figure Legends from Epigenetic Deregulation Across Chromosome 2q14.2 Differentiates Normal from Prostate Cancer and Provides a Regional Panel of Novel DNA Methylation Cancer Biomarkers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252a4269c43dc8ce70e78223ce0847e0
https://doi.org/10.1158/1055-9965.22435216.v1
https://doi.org/10.1158/1055-9965.22435216.v1
Autor:
Susan J. Clark, Robert L. Sutherland, Miguel A. Peinado, Regina Mayor, Anne-Maree Haynes, Ruth Pe Benito, Susan M. Henshall, James G. Kench, Toby Hulf, Marcel W. Coolen, Bruce Tabor, Lisa G. Horvath, Kate I. Patterson, Aaron L. Statham, Jenny Z. Song, Wenjia Qu, Clare Stirzaker, James Devaney
Supplementary Figure 4 from Epigenetic Deregulation Across Chromosome 2q14.2 Differentiates Normal from Prostate Cancer and Provides a Regional Panel of Novel DNA Methylation Cancer Biomarkers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4eb57e5a6e429607729ebd1738ef7b
https://doi.org/10.1158/1055-9965.22435219
https://doi.org/10.1158/1055-9965.22435219
Autor:
Susan J. Clark, Robert L. Sutherland, Miguel A. Peinado, Regina Mayor, Anne-Maree Haynes, Ruth Pe Benito, Susan M. Henshall, James G. Kench, Toby Hulf, Marcel W. Coolen, Bruce Tabor, Lisa G. Horvath, Kate I. Patterson, Aaron L. Statham, Jenny Z. Song, Wenjia Qu, Clare Stirzaker, James Devaney
Supplementary Figure 1 from Epigenetic Deregulation Across Chromosome 2q14.2 Differentiates Normal from Prostate Cancer and Provides a Regional Panel of Novel DNA Methylation Cancer Biomarkers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5a616c1f2927e01692b783ef05835e
https://doi.org/10.1158/1055-9965.22435228
https://doi.org/10.1158/1055-9965.22435228
Autor:
Susan J. Clark, Robert L. Sutherland, Miguel A. Peinado, Regina Mayor, Anne-Maree Haynes, Ruth Pe Benito, Susan M. Henshall, James G. Kench, Toby Hulf, Marcel W. Coolen, Bruce Tabor, Lisa G. Horvath, Kate I. Patterson, Aaron L. Statham, Jenny Z. Song, Wenjia Qu, Clare Stirzaker, James Devaney
Background: Previously, we showed that gene suppression commonly occurs across chromosome 2q14.2 in colorectal cancer, through a process of long-range epigenetic silencing (LRES), involving a combination of DNA methylation and repressive histone modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce59f6104fe646814024aed94002da2
https://doi.org/10.1158/1055-9965.c.6514801.v1
https://doi.org/10.1158/1055-9965.c.6514801.v1