Výsledky vyhledávání - "Aaron L. Hecht"

Akademický článek

Enterobacteriaceae Growth Promotion by Intestinal Acylcarnitines, a Biomarker of Dysbiosis in Inflammatory Bowel DiseaseSummary

Autor: Johanna M.S. Lemons, Maire Conrad, Ceylan Tanes, Jie Chen, Elliot S. Friedman, Manuela Roggiani, Dylan Curry, Lillian Chau, Aaron L. Hecht, Lisa Harling, Jennifer Vales, Kelly E. Kachelries, Robert N. Baldassano, Mark Goulian, Kyle Bittinger, Stephen R. Master, LinShu Liu, Gary D. Wu

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 1, Pp 131-148 (2024)

Background & Aims: Altered plasma acylcarnitine levels are well-known biomarkers for a variety of mitochondrial fatty acid oxidation disorders and can be used as an alternative energy source for the intestinal epithelium when short-chain fatty acids

Externí odkaz: https://doaj.org/article/8f66c2b4eaed489691f98f9562d5b372

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Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis

Autor: Aaron L. Hecht, Wei Ping Teoh, Juliane Bubeck Wardenburg, Julien Herrou, Jerrold R. Turner, Vivian M. Choi, Sean Crosson

Publikováno v: Nature medicine

Bacteroides fragilis is the leading cause of anaerobic bacteremia and sepsis. Enterotoxigenic strains that produce B. fragilis toxin (BFT, fragilysin) contribute to colitis and intestinal malignancy, yet are also isolated in bloodstream infection. It

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e06be121f60f749aa86fa7f1ada510
http://europepmc.org/articles/PMC4860040

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The Bacteroides fragilis pathogenicity island links virulence and strain competition

Autor: Vivian M. Choi, Aaron L. Hecht, Benjamin W. Casterline, Juliane Bubeck Wardenburg

The mature microbiome is a stable ecosystem that resists perturbation despite constant host exposure to exogenous microbes. However, the microbial mechanisms determining microbiome development and composition are poorly understood. We recently demons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c416c7a48a1baba9d8f119cf66a1ff6d
https://europepmc.org/articles/PMC5570422/

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A Two-Component System Regulates Bacteroides fragilis Toxin to Maintain Intestinal Homeostasis and Prevent Lethal Disease

Autor: Juliane Bubeck Wardenburg, Aaron L. Hecht, Vivian M. Choi, Benjamin W. Casterline

Publikováno v: Cell hostmicrobe. 22(4)

Intestinal microbes are recognized for their role in human disease. Enterotoxigenic Bacteroides fragilis (ETBF) has been implicated in inflammatory bowel disease and colorectal cancer; however, colonization alone is insufficient to cause these illnes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9267dfbcee2b209c9e0aa7f680e881d
https://pubmed.ncbi.nlm.nih.gov/29021597

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Strain competition restricts colonization of an enteric pathogen and prevents colitis

Autor: David R. Goodlett, Young Ah Goo, Zachary M. Earley, Benjamin W. Casterline, Aaron L. Hecht, Juliane Bubeck Wardenburg

Publikováno v: EMBO reports. 17(9)

Bacteria of the phylum Bacteroidetes constitute a substantial portion of the human gut microbiota, including symbionts and opportunistic pathogens. How these bacteria coexist and provide colonization resistance to pathogenic strains is not well under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2889e49224a6ba32ddc9ad37828a07
https://pubmed.ncbi.nlm.nih.gov/27506890

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