Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Aaron L Sarver"'
Autor:
Marc A Becker, Yasir H Ibrahim, Annabell S Oh, Dedra H Fagan, Sara A Byron, Aaron L Sarver, Adrian V Lee, Leslie M Shaw, Cheng Fan, Charles M Perou, Douglas Yee
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150564 (2016)
Therapies targeting the type I insulin-like growth factor receptor (IGF-1R) have not been developed with predictive biomarkers to identify tumors with receptor activation. We have previously shown that the insulin receptor substrate (IRS) adaptor pro
Externí odkaz:
https://doaj.org/article/b3a2a113adc349f9a86de76741740fe5
Autor:
Noriko Tonomura, Ingegerd Elvers, Rachael Thomas, Kate Megquier, Jason Turner-Maier, Cedric Howald, Aaron L Sarver, Ross Swofford, Aric M Frantz, Daisuke Ito, Evan Mauceli, Maja Arendt, Hyun Ji Noh, Michele Koltookian, Tara Biagi, Sarah Fryc, Christina Williams, Anne C Avery, Jong-Hyuk Kim, Lisa Barber, Kristine Burgess, Eric S Lander, Elinor K Karlsson, Chieko Azuma, Jaime F Modiano, Matthew Breen, Kerstin Lindblad-Toh
Publikováno v:
PLoS Genetics, Vol 11, Iss 2, p e1004922 (2015)
Dogs, with their breed-determined limited genetic background, are great models of human disease including cancer. Canine B-cell lymphoma and hemangiosarcoma are both malignancies of the hematologic system that are clinically and histologically simila
Externí odkaz:
https://doaj.org/article/5b00e49abada4f5abe8f6eab4d5205b1
Autor:
Raha A Been, Michael A Linden, Courtney J Hager, Krista J DeCoursin, Juan E Abrahante, Sean R Landman, Michael Steinbach, Aaron L Sarver, David A Largaespada, Timothy K Starr
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97280 (2014)
Histiocytic sarcoma is a rare, aggressive neoplasm that responds poorly to therapy. Histiocytic sarcoma is thought to arise from macrophage precursor cells via genetic changes that are largely undefined. To improve our understanding of the etiology o
Externí odkaz:
https://doaj.org/article/fd34e899663546a0b2155c0e9b95ad2e
Autor:
Venugopal Thayanithy, ChangWon Park, Aaron L Sarver, Reena V Kartha, Derek M Korpela, Ashley J Graef, Clifford J Steer, Jaime F Modiano, Subbaya Subramanian
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e43720 (2012)
Downregulation of microRNAs (miRNAs) at the 14q32 locus stabilizes the expression of cMYC, thus significantly contributing to osteosarcoma (OS) pathobiology. Here, we show that downregulation of 14q32 miRNAs is epigenetically regulated. The predicted
Externí odkaz:
https://doaj.org/article/b9d298e242d24dcda4d8522d88044f7f
Autor:
Ann L Oberg, Amy J French, Aaron L Sarver, Subbaya Subramanian, Bruce W Morlan, Shaun M Riska, Pedro M Borralho, Julie M Cunningham, Lisa A Boardman, Liang Wang, Thomas C Smyrk, Yan Asmann, Clifford J Steer, Stephen N Thibodeau
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20465 (2011)
Changes in miRNA expression are a common feature in colon cancer. Those changes occurring in the transition from normal to adenoma and from adenoma to carcinoma, however, have not been well defined. Additionally, miRNA changes among tumor subgroups o
Externí odkaz:
https://doaj.org/article/f4d0f3cdd8ea4a0685a81183c254f6b1
Autor:
Aaron L. Sarver, Lauren J. Mills, Kelly M. Makielski, Nuri A. Temiz, Jinhua Wang, Logan G. Spector, Subbaya Subramanian, Jaime F. Modiano
Publikováno v:
Cancer Genetics. :1-11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ce3c99a00cc28e908fec151a0d8adaa
https://doi.org/10.1016/j.cancergen.2023.05.001
https://doi.org/10.1016/j.cancergen.2023.05.001
Autor:
Kelly M. Makielski, Aaron L. Sarver, Michael S. Henson, Kathleen M. Stuebner, Antonella Borgatti, Lukkana Suksanpaisan, Caitlin Preusser, Alexandru-Flaviu Tabaran, Ingrid Cornax, M. Gerard O’Sullivan, Andrea Chehadeh, Donna Groschen, Kelly Bergsrud, Sara Pracht, Amber Winter, Lauren J. Mills, Marc D. Schwabenlander, Melissa Wolfe, Michael A. Farrar, Gary R. Cutter, Joseph S. Koopmeiners, Stephen J. Russell, Jaime F. Modiano, Shruthi Naik
Publikováno v:
bioRxiv
VSV-IFNβ-NIS is a recombinant oncolytic vesicular stomatitis virus (VSV) that is being evaluated clinically for the treatment of advanced malignancies. As with other cancer immunotherapies, identifying biomarkers of response will be critical to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c7479aafb74daf0df9b4d7bd0ee63e
https://europepmc.org/articles/PMC10153185/
https://europepmc.org/articles/PMC10153185/
Autor:
David A. Largaespada, Nancy Ratner, Stephen C. Schmechel, Margaret R. Wallace, Aaron L. Sarver, Margaret H. Collins, Colleen L. Forster, Anthony E. Rizzardi, Vincent W. Keng, Brian R. Wahl, Leah K. Anderson, Amanda L. Halfond, Andrew D. Greeley, Caitlin B. Conboy, Kwangmin Choi, Branden S. Moriarity, Eric P. Rahrmann, Adrienne L. Watson
Supplementary Figure 4 - PDF file 111K, Reduction of Wnt signaling by β-catenin knockdown or GSK3B overexpression reduces tumor growth in xenograft models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bce1b4500ae8aa47f763841e42aa42b
https://doi.org/10.1158/2159-8290.22530711
https://doi.org/10.1158/2159-8290.22530711
Autor:
Kerstin Lindblad-Toh, Ingegerd Elvers, Jaime F. Modiano, Matthew Breen, Elinor K. Karlsson, Rachael Thomas, Corrie Painter, Jessica Alfoldi, Noriko Tonomura, Luke Borst, Ashley J. Schulte, Milcah C. Scott, Mitzi Lewellen, Michele Koltookian, Jeremy Johnson, Sharadha Sakthikumar, Chao Wang, Aaron L. Sarver, Jong-Hyuk Kim, Ross Swofford, Jason Turner-Maier, Kate Megquier
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c32caa37ff058953d7c8963ec184eda
https://doi.org/10.1158/1541-7786.22515477.v1
https://doi.org/10.1158/1541-7786.22515477.v1
Autor:
Kerstin Lindblad-Toh, Ingegerd Elvers, Jaime F. Modiano, Matthew Breen, Elinor K. Karlsson, Rachael Thomas, Corrie Painter, Jessica Alfoldi, Noriko Tonomura, Luke Borst, Ashley J. Schulte, Milcah C. Scott, Mitzi Lewellen, Michele Koltookian, Jeremy Johnson, Sharadha Sakthikumar, Chao Wang, Aaron L. Sarver, Jong-Hyuk Kim, Ross Swofford, Jason Turner-Maier, Kate Megquier
Table S1. Canine cohort metadata Table S2. Canine library preparation, amplification, and complexity Table S3. COSMIC Cancer Gene Census genes Table S4. Summary of canine RNA-seq data Table S5. RNA-seq validation Table S6. RNA-seq survey Table S7. En
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8e0170833c99fa01b267c8b24042e9
https://doi.org/10.1158/1541-7786.22515474.v1
https://doi.org/10.1158/1541-7786.22515474.v1