Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Aaron L Carlson"'
Autor:
Teresa M DesRochers, Danielle Nadeau, Katy A Lassahn, Ashley K Elrod, Natalie W Dance, Kimberly J Burgess, Aaron L Carlson, Melissa Millard, Michael J Wick, Kathryn M Appleton
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/766d95c0b234474891756f460d0c7398
Autor:
Jason Wang, Chris J. Zhou, Alastair Khodabukus, Sabrina Tran, Sang-Oh Han, Aaron L. Carlson, Lauran Madden, Priya S. Kishnani, Dwight D. Koeberl, Nenad Bursac
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Wang et al. describe the development of a 3D in vitro model of human skeletal muscle that recapitulates the pathophysiology of Pompe disease. They further define a Pompe disease-specific transcriptional signature, confirm its presence in the Pompe my
Externí odkaz:
https://doaj.org/article/e7bed5b1c04b4acdbdebddf5309410f2
Autor:
Ilya Y. Shadrin, Brian W. Allen, Ying Qian, Christopher P. Jackman, Aaron L. Carlson, Mark E. Juhas, Nenad Bursac
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Cardiomyocytes derived from human induced pluripotent stem cells could be used to generate cardiac tissues for regenerative purposes. Here the authors describe a method to obtain large bioengineered heart tissues showing advanced maturation, function
Externí odkaz:
https://doaj.org/article/cf30a3c33e6d47d2acb195744c55d771
Autor:
Aaron L. Carlson, Neal K. Bennett, Nicola L. Francis, Apoorva Halikere, Stephen Clarke, Jennifer C. Moore, Ronald P. Hart, Kenneth Paradiso, Marius Wernig, Joachim Kohn, Zhiping P. Pang, Prabhas V. Moghe
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Human pluripotent stem cell derived neurons have the potential for cell replacement therapy for brain injury and disease but problems on transplantation need to be overcome. Here, the authors use a microtopographic scaffold to graft neurons into both
Externí odkaz:
https://doaj.org/article/1cdbd92bc9c24daca3285c1be2d05c12
Autor:
Dwight D. Koeberl, Sabrina Tran, Chris J. Zhou, Alastair Khodabukus, Lauran Madden, Aaron L. Carlson, Priya S. Kishnani, Jason Wang, Nenad Bursac, Sang-oh Han
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Communications Biology
In Pompe disease, the deficiency of the lysosomal enzyme acid alpha-glucosidase (GAA) causes skeletal and cardiac muscle weakness, respiratory failure, and premature death. While enzyme replacement therapy using recombinant human GAA (rhGAA) can sign
Autor:
Katy A. Lassahn, Ashley K. Elrod, Aaron L. Carlson, Natalie A. Dance, Melissa Millard, Michael J. Wick, Teresa M. DesRochers, Kathryn M. Appleton
Publikováno v:
Cancer Research. 83:2275-2275
Biological therapies for the treatment of cancer are utilized for the same ultimate purpose as chemically derived cancer drugs, to induce tumor cell death. However, the differing mechanisms of action often make the evaluation of biologic drug efficac
Publikováno v:
Weed Technology. 33:431-440
Sugarbeet growers only recently have combined ethofumesate, S-metolachlor, and dimethenamid-P in a weed control system for waterhemp control. Sugarbeet plant density, visible stature reduction, root yield, percent sucrose content, and recoverable suc
Autor:
Aaron L. Carlson, Ashley K. Elrod, Natalie A. Williams, Alyssa D. Moriarty, Michael J. Wick, Teresa M. DesRochers
Publikováno v:
Cancer Research. 82:183-183
Patient-Derived Xenografts (PDX) represent a versatile tool for preclinical drug development because they recapitulate many key features of the parent tumors, including molecular and histopathological profiles, tumor microenvironment, and tumor heter
Autor:
Aaron L. Carlson, Ilya Y. Shadrin, Mark Juhas, Christopher P. Jackman, Brian W. Allen, Ying Qian, Nenad Bursac
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications
Despite increased use of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for drug development and disease modeling studies, methods to generate large, functional heart tissues for human therapy are lacking. Here we present a
Autor:
Joachim Kohn, Ronald P. Hart, Kenneth G Paradiso, Prabhas V. Moghe, Neal K. Bennett, Marius Wernig, Zhiping P. Pang, Jennifer C. Moore, Stephen G. Clarke, Nicola L. Francis, Aaron L. Carlson, Apoorva Halikere
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
Nature Communications
Cell replacement therapy with human pluripotent stem cell-derived neurons has the potential to ameliorate neurodegenerative dysfunction and central nervous system injuries, but reprogrammed neurons are dissociated and spatially disorganized during tr