Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Aaron Kucinski"'
Publikováno v:
Mov Disord
Background In movement disorders such as Parkinson's disease (PD), cholinergic signaling is disrupted by the loss of basal forebrain cholinergic neurons, as well as aberrant activity in striatal cholinergic interneurons (ChIs). Several lines of evide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35d91c2698733e551ada8c1c546a436
https://doi.org/10.1002/mds.28532
https://doi.org/10.1002/mds.28532
Publikováno v:
eneuro. 9:ENEURO.0418-22.2022
Sign tracking versus goal tracking in rats indicate vulnerability and resistance, respectively, to Pavlovian cue-evoked addictive drug taking and relapse. Here, we tested hypotheses predicting that the opponent cognitive-behavioral styles indexed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52df66662bddcc83f4955e5258ef649e
https://doi.org/10.1523/eneuro.0418-22.2022
https://doi.org/10.1523/eneuro.0418-22.2022
Publikováno v:
Behavioral Neuroscience. 133:121-134
Sign- and goal-tracking behavior signifies the influence of opposed cognitive-motivational styles, with the former being characterized by a tendency for approaching and contacting reward cues, including a readiness for attending, bottom-up, to salien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971cfc0c15e56e684e23b3c3f76e9885
https://doi.org/10.1037/bne0000290
https://doi.org/10.1037/bne0000290
Autor:
Martin Sarter, Aaron Kucinski
Publikováno v:
Psychopharmacology
Rationale In addition to the disease-defining motor symptoms, patients with Parkinson’s disease (PD) exhibit gait dysfunction, postural instability, and a propensity for falls. These dopamine (DA) replacement-resistant symptoms in part have been at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86bc4ac6f31929ff093f726da716d00b
https://pubmed.ncbi.nlm.nih.gov/33735392
https://pubmed.ncbi.nlm.nih.gov/33735392
Publikováno v:
Psychopharmacology. 237(1)
Loss of basal forebrain cholinergic neurons contributes to the severity of the cognitive decline in age-related dementia and, in patients with Parkinson’s disease (PD), to impairments in gait and balance and the resulting risks for falls. Contrasti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10695e8abb2a2e42e0932223cce1b6e
https://pubmed.ncbi.nlm.nih.gov/31620809
https://pubmed.ncbi.nlm.nih.gov/31620809
Loss of basal forebrain cholinergic neurons contributes to the severity of the cognitive decline in age-related dementia and to impairments in gait and balance, and the resulting risks for falls, in patients with Parkinson’s disease (PD). Contrasti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52c3dd4e82ca46d4c8f2d0cb5a7c895
https://doi.org/10.1101/606343
https://doi.org/10.1101/606343
Autor:
Randy D. Blakely, Aaron Kucinski, Martin Sarter, Natalie C. Tronson, Ajeesh Koshy Cherian, Vinay Parikh
Publikováno v:
Behav Neurosci
Previous research emphasized the impact of traumatic brain injury on cholinergic systems and associated cognitive functions. Here we addressed the converse question: Because of the available evidence indicating cognitive and neuronal vulnerabilities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e599ad72743cf1ba9838dacf1c60ab1
https://doi.org/10.1101/521484
https://doi.org/10.1101/521484
Publikováno v:
European Journal of Neuroscience. 45:217-231
Falls are a leading cause of death in the elderly and, in a majority of patients with Parkinson's disease (PD), the leading levodopa-insensitive cause of hospitalization and long-term care. Falling in PD has been attributed to degeneration of forebra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b502a33300f91740f75bd9d8098a694d
https://doi.org/10.1111/ejn.13354
https://doi.org/10.1111/ejn.13354
Cognitive-motivational vulnerability traits are associated with increased risk for substance addiction and relapse. Sign-tracking (ST) behavior in rats is associated with poor attentional control, mediated by an unresponsive basal forebrain cholinerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a971e384d591d08be2c4d30da6e5cf7
https://europepmc.org/articles/PMC6506847/
https://europepmc.org/articles/PMC6506847/
Publikováno v:
Behavioural Brain Research. 282:155-164
Falls in patients with Parkinson's disease (PD) are a major and levodopa-unresponsive source of morbidity. We previously described an animal model of falls resulting from impairments in attentional–motor interactions. Reproducing the multisystem do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6ad90959729975cff99f8aae5ec4da
https://doi.org/10.1016/j.bbr.2015.01.012
https://doi.org/10.1016/j.bbr.2015.01.012