Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Aaron K. Neumann"'
Autor:
Brian I. Grajeda, Atasi De Chatterjee, Carmen M. Villalobos, Breanna C. Pence, Cameron C. Ellis, Vanessa Enriquez, Sourav Roy, Sukla Roychowdhury, Aaron K. Neumann, Igor C. Almeida, Steven E. Patterson, Siddhartha Das
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Giardia lamblia, a protozoan parasite, is a major cause of waterborne infection, worldwide. While the trophozoite form of this parasite induces pathological symptoms in the gut, the cyst form transmits the infection. Since Giardia is a noninvasive pa
Externí odkaz:
https://doaj.org/article/fdb0433ce79d486ca65acedb887ae7bb
Autor:
Rohan P. Choraghe, Aaron K. Neumann
Publikováno v:
Life, Vol 11, Iss 2, p 108 (2021)
At host–pathogen contact sites with Candida albicans, Dectin-1 activates pro-inflammatory signaling, while DC-SIGN promotes adhesion to the fungal surface. We observed that Dectin-1 and DC-SIGN collaborate to enhance capture/retention of C. albican
Externí odkaz:
https://doaj.org/article/ea42d755ac8d486c9c6a07294485c0ce
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188599 (2017)
Candida albicans is a virulent human opportunistic pathogen. It evades innate immune surveillance by masking an immunogenic cell wall polysaccharide, β-glucan, from recognition by the immunoreceptor Dectin-1. Glucan unmasking by the antifungal drug
Externí odkaz:
https://doaj.org/article/395edde4584848808f78959241ad3886
Autor:
Michelle S Itano, Matthew S Graus, Carolyn ePehlke, Michael J Wester, Ping eLiu, Keith A Lidke, Nancy L Thompson, Ken eJacobson, Aaron K Neumann
Publikováno v:
Frontiers in Physics, Vol 2 (2014)
Dendritic cells express DC-SIGN and CD206, C-type lectins (CTLs) that bind a variety of pathogens and may facilitate pathogen uptake for subsequent antigen presentation. Both proteins form punctate membrane nanodomains (~80 nm) on naïve cells. We an
Externí odkaz:
https://doaj.org/article/3b53ccae7b03414281af8451095170f7
Publikováno v:
J Cell Sci
Dectin-1 (Dendritic Cell associated C-type Lectin 1) is an innate immune pattern recognition receptor which recognizes β-glucan on the Candida albicans (C. albicans) cell wall. Recognition of β-glucan by immune cells leads to phagocytosis, oxidativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b3625ea23d864864170fd38cd2fe41
https://europepmc.org/articles/PMC7063837/
https://europepmc.org/articles/PMC7063837/
Autor:
Aaron K Neumann, Ken Jacobson
Publikováno v:
PLoS Pathogens, Vol 6, Iss 2, p e1000760 (2010)
Fungal pathologies are seen in immunocompromised and healthy humans. C-type lectins expressed on immature dendritic cells (DC) recognize fungi. We report a novel dorsal pseudopodial protrusion, the "fungipod", formed by DC after contact with yeast ce
Externí odkaz:
https://doaj.org/article/02eae7db0a714151a4212110d5748135
Autor:
Hongyan Li, Hirohito Kita, Diane L. Squillace, Liwu Li, Tony Y. Hu, Aaron K. Neumann, Brad A. Howard, Yang Liu, David C. Samuels, Bruce S. Klein, Mengyao Luo, Xin He, Shiv D. Kale, Caroline Jones, Uju Joy Okaa, Christopher B. Lawrence, Nidhi Menon, Trenton Kite, Tiffany Roach
Publikováno v:
Cell reports
SUMMARY Chitin, a major component of fungal cell walls, has been associated with allergic disorders such as asthma. However, it is unclear how mammals recognize chitin and the principal receptor(s) on epithelial cells that sense chitin remain to be d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ed82f66050d535ddbe2b49b61c07d9
https://doi.org/10.1016/j.celrep.2021.109392
https://doi.org/10.1016/j.celrep.2021.109392
Autor:
Aaron K. Neumann, Akram Etemadi Amin, Kyle S. Michel, Eduardo U. Anaya, Mike Danielson, Michael J. Wester
Dectin-1A is a C-type Lectin innate immunoreceptor that recognizes β-(1,3;1,6)-glucan, a structural component of Candida species cell walls. The higher order structure of β-glucans ranges from random coil to insoluble fiber due to varying degrees o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f37583cf69c7c782ae5bc6fd4cbec87
https://doi.org/10.1101/824995
https://doi.org/10.1101/824995
Dectin-1 is an innate immune pattern recognition receptor which recognizes β-glucan on theCandida albicans(C. albicans) cell wall. Recognition of β-glucan by immune cells leads to phagocytosis, oxidative burst, cytokine and chemokine production. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becfe8a14ba0dbe7194538d80992b6ad
Autor:
Patrick L. Donabedian, David G. Whitten, Harry C. Pappas, Matthew S. Graus, Aaron K. Neumann, Rina Sylejmani
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:4519-4529
Candida species are the cause of many bloodstream infections through contamination of indwelling medical devices. These infections account for a 40% mortality rate, posing a significant risk to immunocompromised patients. Traditional treatments again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9eaf6f3b56034b7c68d9b88def6858
https://doi.org/10.1128/aac.00317-16
https://doi.org/10.1128/aac.00317-16