Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Aaron Jeffries"'
Autor:
Samuel Kraus, Megan L Fletcher, Urszula Łapińska, Krina Chawla, Evan Baker, Erin L Attrill, Paul O'Neill, Audrey Farbos, Aaron Jeffries, Edouard E Galyov, Sunee Korbsrisate, Kay B Barnes, Sarah V Harding, Krasimira Tsaneva-Atanasova, Mark A T Blaskovich, Stefano Pagliara
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012361 (2024)
The interactions between a virus and its host vary in space and time and are affected by the presence of molecules that alter the physiology of either the host or the virus. Determining the molecular mechanisms at the basis of these interactions is p
Externí odkaz:
https://doaj.org/article/b6c3583e1ed849f4a0d265bd93bc466b
Autor:
Olivia Goode, Ashley Smith, Ashraf Zarkan, Jehangir Cama, Brandon M. Invergo, Daaniyah Belgami, Santiago Caño-Muñiz, Jeremy Metz, Paul O’Neill, Aaron Jeffries, Isobel H. Norville, Jonathan David, David Summers, Stefano Pagliara
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Persister and viable but non-culturable (VBNC) cells are two clonal subpopulations that can survive multidrug exposure via a plethora of putative molecular mechanisms. Here, we combine microfluidics, time-lapse microscopy, and a plasmid-enco
Externí odkaz:
https://doaj.org/article/6d1f31061d5a4954937de418453ed324
Autor:
Jennifer Imm, Ehsan Pishva, Muhammadd Ali, Talitha L. Kerrigan, Aaron Jeffries, Joe Burrage, Enrico Glaab, Emma L. Cope, Kimberley M. Jones, Nicholas D. Allen, Katie Lunnon
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
In development, differentiation from a pluripotent state results in global epigenetic changes, although the extent to which this occurs in induced pluripotent stem cell-based neuronal models has not been extensively characterized. In the present stud
Externí odkaz:
https://doaj.org/article/74e3d6a630b7493ab30116c44663fb95
Autor:
Isabel Castanho, Tracey K. Murray, Eilis Hannon, Aaron Jeffries, Emma Walker, Emma Laing, Hedley Baulf, Joshua Harvey, Lauren Bradshaw, Andrew Randall, Karen Moore, Paul O’Neill, Katie Lunnon, David A. Collier, Zeshan Ahmed, Michael J. O’Neill, Jonathan Mill
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 2040-2054.e5 (2020)
Summary: Alzheimer’s disease (AD) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. We use transgenic mice harboring human tau (rTg4510) and amyloid precursor protein (J
Externí odkaz:
https://doaj.org/article/3cad2ca98a4f435e9d9d2b16cb529f93
Autor:
Matthew Devall, Rebecca G. Smith, Aaron Jeffries, Eilis Hannon, Matthew N. Davies, Leonard Schalkwyk, Jonathan Mill, Michael Weedon, Katie Lunnon
Publikováno v:
Clinical Epigenetics, Vol 9, Iss 1, Pp 1-15 (2017)
Abstract Background DNA methylation is an important epigenetic mechanism involved in gene regulation, with alterations in DNA methylation in the nuclear genome being linked to numerous complex diseases. Mitochondrial DNA methylation is a phenomenon t
Externí odkaz:
https://doaj.org/article/945ea65b766b4c2fbd4624efbe9dede7
Autor:
Sam J. Washer, Robert Flynn, Asami Oguro‐Ando, Eilis Hannon, Joe Burrage, Aaron Jeffries, Jonathan Mill, Emma L. Dempster
Publikováno v:
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 189(5)
Genome-wide association studies (GWAS) have identified multiple genomic regions associated with schizophrenia, although many variants reside in noncoding regions characterized by high linkage disequilibrium (LD) making the elucidation of molecular me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14807b8d8d285dc4f0c325a2d728203f
https://pubmed.ncbi.nlm.nih.gov/35719055
https://pubmed.ncbi.nlm.nih.gov/35719055
Autor:
Helle Lybæk, Michael Robson, Nicole Leeuw, Jayne Y. Hehir‐Kwa, Aaron Jeffries, Bjørn Ivar Haukanes, Siren Berland, Diederik Bruijn, Stefan Mundlos, Malte Spielmann, Gunnar Houge
Publikováno v:
Autism Research
Autism Research, 15, 421-433
Autism Research, 15, 3, pp. 421-433
Autism Research, 15, 421-433
Autism Research, 15, 3, pp. 421-433
Contains fulltext : 248379.pdf (Publisher’s version ) (Open Access) LRFN5 is a regulator of synaptic development and the only gene in a 5.4 Mb mammalian-specific conserved topologically associating domain (TAD); the LRFN5 locus. An association betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79bd69eded6ad47ff2357a8de87088ab
https://doi.org/10.1002/aur.2677
https://doi.org/10.1002/aur.2677
Autor:
Malte Spielmann, Michael I. Robson, Diederik R.H. de Bruijn, Bjørn Ivar Haukanes, Gunnar Houge, Siren Berland, Aaron Jeffries, Stefan Mundlos, Nicole de Leeuw, Jayne Y. Hehir-Kwa, Helle Lybæk
BackgroundLRFN5 is a brain-specific gene needed for synaptic development and plasticity. It is the only gene in a large 5.4 Mb topologically associating domain (TAD) on chromosome 14, which we term the LRFN5 locus. This locus is highly conserved, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50730dbd07e8b8145e6d4f6cb2156df5
https://doi.org/10.21203/rs.3.rs-895724/v1
https://doi.org/10.21203/rs.3.rs-895724/v1
Publikováno v:
European Neuropsychopharmacology. 29:S1116-S1117
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fcd9d765146ff7a42eebd11253d4b29
https://doi.org/10.1016/j.euroneuro.2018.08.093
https://doi.org/10.1016/j.euroneuro.2018.08.093
Publikováno v:
Stem Cells & Development; Nov2011, Vol. 20 Issue 11, p1873-1887, 15p