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of 2
pro vyhledávání: '"Aaron J. Sundholm"'
Autor:
Bruce E. Magun, Anjali D. Dotson, David E. Purdy, Mihail S. Iordanov, Pascal Schneider, Sherry M. Farley, Aaron J. Sundholm
Publikováno v:
Journal of Investigative Dermatology, vol. 126, no. 11, pp. 2438-2451
Fas ligand (FasL) causes apoptosis of epidermal keratinocytes and triggers the appearance of spongiosis in eczematous dermatitis. We demonstrate here that FasL also aggravates inflammation by triggering the expression of proinflammatory cytokines, ch
Autor:
Bruce E. Magun, Remy J. Choi, Pascal Schneider, Aaron J. Sundholm, Mihail S. Iordanov, Jon M. Hanifin, Olga P. Ryabinina, Veselina Korcheva, Eric L. Simpson
Publikováno v:
Journal of Investigative Dermatology, vol. 125, no. 1, pp. 134-142
Recent findings have implicated Fas/Fas ligand (FasL) in mediating the death of keratinocytes in spongiotic lesions. We asked whether dying keratinocytes could potentially initiate a protective response of the skin to limit the destruction of the epi