Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Aaron J. Maurais"'
Autor:
Andrew R. Henderson, Corinna S. Schindler, Eranthie Weerapana, Kyle S. Cole, Aaron J. Maurais, James R. Annand, Yejun Liu, Angela N. Koehler, Jorge Becerra, Anna K. Mapp
Publikováno v:
ACS Med Chem Lett
[Image: see text] The small molecule gibberellin JRA-003 was identified as an inhibitor of the NF-kB (nuclear kappa-light-chain-enhancer of activated B cells) pathway. Here we find that JRA-003 binds to and significantly inhibits the nuclear transloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a3be26f506b3f8b727bc5dd63cce38
https://doi.org/10.1021/acsmedchemlett.9b00613
https://doi.org/10.1021/acsmedchemlett.9b00613
Autor:
Micaela Tobin, Scott A. Shaffer, Paul R. Thompson, Ari J. Salinger, Aaron J. Maurais, Eranthie Weerapana
Publikováno v:
Biochemistry
Citrullination is an enzyme-catalyzed post-translational modification (PTM) that is essential for a host of biological processes, including gene regulation, programmed cell death, and organ development. While this PTM is required for normal cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18da52f8262b29b05dba15e1609d5b13
https://pubmed.ncbi.nlm.nih.gov/34491035
https://pubmed.ncbi.nlm.nih.gov/34491035
Publikováno v:
ACS Chem Biol
The endoplasmic reticulum (ER) is the initial site of biogenesis of secretory pathway proteins, including proteins localized to the ER, Golgi, lysosomes, intracellular vesicles, plasma membrane, and extracellular compartments. Proteins within the sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfec2a39260e0249f03d2310d399fbe
https://doi.org/10.1021/acschembio.9b01014
https://doi.org/10.1021/acschembio.9b01014
Autor:
Sangram S. Parelkar, Li Zheng, Mitesh Nagar, Eranthie Weerapana, Daniel J. Slade, Aaron J. Maurais, Paul R. Thompson, Scott A. Coonrod
Publikováno v:
Biochemistry
Protein arginine deiminases (PADs) are calcium-dependent enzymes that mediate the post-translational conversion of arginine into citrulline. Dysregulated PAD activity is associated with numerous autoimmune disorders and cancers. In breast cancer, PAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d8642df9623a4637b0505744cf7f02
https://doi.org/10.1021/acs.biochem.9b00225
https://doi.org/10.1021/acs.biochem.9b00225
Autor:
Aaron J. Maurais, Eranthie Weerapana
Publikováno v:
Curr Opin Chem Biol
The recognition that only a small percentage of known human gene products are druggable using traditional modes of non-covalent ligand design, has led to a resurgence in targeted covalent inhibitors. Covalent inhibitors offer advantages over non-cova
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa45373349ad6e6c7a64dc59e8a8b74
https://doi.org/10.1016/j.cbpa.2019.02.010
https://doi.org/10.1016/j.cbpa.2019.02.010
Publikováno v:
Gastroenterology. 162:S-75
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89583d77081908e2ca154a745224577c
https://doi.org/10.1016/s0016-5085(22)60190-2
https://doi.org/10.1016/s0016-5085(22)60190-2
Autor:
Santanu Mondal, Aaron Muth, Paul R. Thompson, Venkataraman Subramanian, Ari J. Salinger, Ronak Tilvawala, Venkatesh V. Nemmara, Eranthie Weerapana, Aaron J. Maurais
Publikováno v:
ACS chemical biology. 13(3)
Citrullination is the post-translational hydrolysis of peptidyl-arginines to form peptidyl-citrulline, a reaction that is catalyzed by the protein arginine deiminases (PADs), a family of calcium-regulated enzymes. Aberrantly increased protein citrull
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::806eb0559a355ffc93d002ae0fca786c
https://pubmed.ncbi.nlm.nih.gov/29341591
https://pubmed.ncbi.nlm.nih.gov/29341591
Autor:
Mitesh Nagar, Aaron J. Maurais, Venkatesh V. Nemmara, Sunil Nagpal, Ari J. Salinger, Paul R. Thompson, Ronak Tilvawala, Eranthie Weerapana, Son Hong Nguyen
Publikováno v:
Cell Chemical Biology. 25:691-704.e6
Increased protein citrullination is linked to various diseases including rheumatoid arthritis (RA), lupus, and cancer. Citrullinated autoantigens, a hallmark of RA, are recognized by anti-citrullinated protein antibodies (ACPAs) which are used to dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b26769838d18f6062a34ea2837369df
https://doi.org/10.1016/j.chembiol.2018.03.002
https://doi.org/10.1016/j.chembiol.2018.03.002