Výsledky vyhledávání - "Aaron J. Krohn"

Up-regulation of Bcl-xL in response to subtoxic β-amyloid: role in neuronal resistance against apoptotic and oxidative injury

Autor: Jochen H. M. Prehn, S Lankiewicz, Monika Poppe, Aaron J. Krohn, C M Luetjens, N.T Bui

Publikováno v: Neuroscience. 102:139-150

Neuron death in Alzheimer's disease is believed to be triggered by an increased production of amyloidogenic beta-amyloid peptides, involving both increased oxidative stress and activation of a conserved death program. Bcl-xL, an anti-apoptotic protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d2089a022d36c31e9b441f2b7e2c9b
https://doi.org/10.1016/s0306-4522(00)00458-9

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Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype

Autor: Suzanne Craft, Monique M. Cherrier, John W. Newcomer, Andreana Petrova, Aaron J. Krohn, Gerard D. Schellenberg, Sanjay Asthana, Shawn J. Latendresse, Laura D. Baker, Kristina Purganan, G. Stennis Watson, David G. Cook, Colby Wait

Publikováno v: Psychoneuroendocrinology. 28(6)

In previous studies, adults with Alzheimer's disease (AD) showed memory enhancement when plasma insulin levels were raised to 85 microU/ml, whereas normal adults' memory was unchanged. Degree of memory enhancement was also related to apolipoprotein E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf4abeac26176359f650116dd5860ce
https://pubmed.ncbi.nlm.nih.gov/12812866

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Dissipation of potassium and proton gradients inhibits mitochondrial hyperpolarization and cytochrome c release during neural apoptosis

Autor: A L Nieminen, D Böckelmann, Monika Poppe, C M Luetjens, Heiko Düssmann, Aaron J. Krohn, Jochen H. M. Prehn, Claus Reimertz, D Kögel

Publikováno v: ResearcherID
Scopus-Elsevier

Exposure of rat hippocampal neurons or human D283 medulloblastoma cells to the apoptosis-inducing kinase inhibitor staurosporine induced rapid cytochrome c release from mitochondria and activation of the executioner caspase-3. Measurements of cellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366ffb07bc9ee811b3e36f3638fbec23
https://pubmed.ncbi.nlm.nih.gov/11426445

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Delayed mitochondrial dysfunction in excitotoxic neuron death: cytochrome c release and a secondary increase in superoxide production

Autor: C. Marc Luetjens, Nguyen Truc Bui, Jochen H. M. Prehn, Aaron J. Krohn, Elke Bauerbach, Josef Krieglstein, Bernd Sengpiel, Gudrun Münstermann, Monika Poppe

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(15)

An increased production of superoxide has been shown to mediate glutamate-induced neuron death. We monitored intracellular superoxide production of hippocampal neurons during and after exposure to the glutamate receptor agonist NMDA (300 μm). During

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b07772f50ff2bf5b930bfbef824e53
https://pubmed.ncbi.nlm.nih.gov/10908611

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Mitochondrial depolarization is not required for neuronal apoptosis

Autor: Jochen H. M. Prehn, Aaron J. Krohn, Tanja Wahlbrink

Publikováno v: Scopus-Elsevier
ResearcherID

Mitochondria are sites of cellular energy production but may also influence life and death decisions by initiating or inhibiting cell death. Mitochondrial depolarization and the subsequent release of pro-apoptotic factors have been suggested to be re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8525b2a88558cd5b822e15736a3b6d27
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033198273&partnerID=MN8TOARS

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Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death

Autor: Monika Poppe, Takaomi C. Saido, Aaron J. Krohn, C. Marc Luetjens, Greg M. Cole, Jochen H. M. Prehn, Silke Lankiewicz, Nguyen Truc Bui

Publikováno v: ResearcherID

Glutamate receptor overactivation contributes to neuron death after stroke, trauma, and epileptic seizures. Exposure of cultured rat hippocampal neurons to the selective glutamate receptor agonist N-methyl-d-aspartate (300 microm, 5 min) or to the ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d439476df3cceff6fc9bd4e527c38bb
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000087392200093&KeyUID=WOS:000087392200093

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Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector

Autor: Elke Preis, Aaron J. Krohn, Jochen H. M. Prehn

Publikováno v: Scopus-Elsevier
ResearcherID

We induced apoptosis in cultured rat hippocampal neurons by exposure to the protein kinase inhibitor staurosporine (30 nm, 24 hr). Treatment with the antioxidant (±)-α-tocopherol (100 μm) or the superoxide dismutase-mimetic manganese tetrakis (4-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943866ee6efb2cdcd3a5e422d2be7792
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032531823&partnerID=MN8TOARS

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